Heptylstyrylketon | 63301-30-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Heptylstyrylketon
• 英文别名: 1-phenyl-dec-1-en-3-one；1-Phenyl-dec-1-en-3-on；α-n-Hexyl-α'-benzyliden-aceton；γ-Oxo-α-phenyl-α-decylen；1³-Oxo-1-(decen-(1¹)-yl)-benzol；n-Heptyl-styryl-keton；1-Phenyldec-1-en-3-one
• CAS: 63301-30-4
• 化学式: C₁₆H₂₂O
• 分子量: 230.35
• InChiKey: YWKNPRIZEDLBKJ-UHFFFAOYSA-N

物化性质

• 沸点：
  354.6±11.0 °C(Predicted)
• 密度：
  0.947±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Heptylstyrylketon 在 奎宁胺 、 BOC-L-脯氨酸 作用下， 以 四氢呋喃 、 水 、 1,2-二氯乙烷 为溶剂， 反应 108.5h， 生成 (S)-ethyl 2-methylene-5-oxo-3-phenyldodecanoate
  参考文献：
  名称：

  Organocatalytic Asymmetric Michael-Type/Wittig Reaction of Phosphorus Ylides: Synthesis of Chiral α-Methylene-δ-Ketoesters

  摘要：

  An asymmetric Michael-type reaction of phosphorus ylides and alpha,beta-unsaturated ketones under the catalysis of a chiral ion pair catalyst has been described. The ion pair catalyst containing a chiral counteranion was prepared by simply mixing 9-amino-(9-deoxy)-epl-quinine with L-N-Boc-proline. The optically active alpha-methylene-delta-ketoesters could be obtained with good to excellent enantloselectivities (up to 95% ee) under mild reaction conditions.

  DOI：

  10.1021/ol201483s
• 作为产物：
  描述：

  1-anilino-1-phenyl-decan-3-one 在 硫酸 作用下， 生成 Heptylstyrylketon
  参考文献：
  名称：

  Mayer, Bulletin de la Societe Chimique de France, 1905, vol. <3> 33, p. 162

  摘要：

  DOI：

文献信息

• CO₂-Catalyzed Oxidation of Benzylic and Allylic Alcohols with DMSO
  作者：Daniel Riemer、Bhavdip Mandaviya、Waldemar Schilling、Anne Charlotte Götz、Torben Kühl、Markus Finger、Shoubhik Das

  DOI：10.1021/acscatal.7b04390

  日期：2018.4.6

  various primary and secondary alcohols have been selectively oxidized to the corresponding carbonyl compounds using CO2 as a catalyst in the presence of different functional groups such as nitrile, nitro, aldehyde, ester, halogen, ether, and so on. At the end, transition-metal-free syntheses of pharmaceuticals have also been achieved. Finally, the role of CO2 has been investigated in detail, and the

  已经实现了CO 2催化的无过渡金属醇的氧化。早先，已经探索了几种基于过渡金属催化剂的醇氧化方法。但是，由于价格便宜，易于分离且无毒，因此对制药行业的无过渡金属体系的需求很高。因此，在不同的官能团如腈，硝基，醛，酯，卤素，醚等的存在下，使用CO 2作为催化剂将各种伯醇和仲醇选择性氧化为相应的羰基化合物。最后，还实现了药物的无过渡金属合成。最后，CO 2的作用 对此进行了详细的研究，并在实验和DFT计算的基础上提出了该机制。
• Ch.Mayer, Bulletin de la Societe Chimique de France, 1905, vol. <3>33, p. 158
  作者：Ch.Mayer

  DOI：——

  日期：——
• Mid-term Results of the Ross Procedure
  作者：Domenico Paparella、Tirone E. David、Susan Armstrong、Joan Ivanov

  DOI：10.1111/j.1540-8191.2001.tb00533.x

  日期：2001.7

  Although the Ross procedure has been performed for over three decades, its role in the management of patients with aortic valve disease is not well established. This study reviews our experience with this operation. From 1990 to 1999, 155 patients underwent the Ross procedure. The mean age of 106 men and 49 women was 35 years. Most patients (85%) had congenital aortic valve disease. The pulmonary autograft was implanted in the subcoronary position in 2 patients, as an aortic root inclusion in 78, and aortic root replacement in 75. The follow-up extended from 9 to 114 months, mean of 45 +/- 28 months, and it was complete. All patients have had Doppler echocardiographic studies. There was only one operative and one late death. The survival was 98% at 7 years. The freedom from 3+ or 4+ aortic insufficiency was 86% at 7 years and the freedom from reoperation on the pulmonary autograft was 95% at 7 years. Dilation of the aortic annulus and/or sinotubular junction was the most common cause of aortic insufficiency. One patient required three reoperations on the biological pulmonary valve. Most patients (96%) have no cardiac symptoms. The Ross procedure has provided excellent functional results in most patients, but progressive aortic insufficiency due to dilation of the aortic annulus and/or sinotubular junction is a potential problem in a number of patients.
• Organocatalytic Asymmetric Michael-Type/Wittig Reaction of Phosphorus Ylides: Synthesis of Chiral α-Methylene-δ-Ketoesters
  作者：Aijun Lin、Junying Wang、Haibin Mao、Huiming Ge、Renxiang Tan、Chengjian Zhu、Yixiang Cheng

  DOI：10.1021/ol201483s

  日期：2011.8.19

  An asymmetric Michael-type reaction of phosphorus ylides and alpha,beta-unsaturated ketones under the catalysis of a chiral ion pair catalyst has been described. The ion pair catalyst containing a chiral counteranion was prepared by simply mixing 9-amino-(9-deoxy)-epl-quinine with L-N-Boc-proline. The optically active alpha-methylene-delta-ketoesters could be obtained with good to excellent enantloselectivities (up to 95% ee) under mild reaction conditions.
• Mayer, Bulletin de la Societe Chimique de France, 1905, vol. <3> 33, p. 162
  作者：Mayer

  DOI：——

  日期：——