4-benzyloxy-2-dodecylquinolin-6-ol | 1270008-55-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-benzyloxy-2-dodecylquinolin-6-ol
• CAS: 1270008-55-3
• 化学式: C₂₈H₃₇NO₂
• 分子量: 419.607
• InChiKey: NMWIYMIRJIQCHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.98
• 重原子数：
  31.0
• 可旋转键数：
  14.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  42.35
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-benzyloxy-2-dodecylquinolin-6-ol 在 sodium hydride 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 3.5h， 生成 4-benzyloxy-6-[2-(dimethylamino)ethoxy]-2-dodecylquinoline N,N'-dioxide
  参考文献：
  名称：

  Synthesis of Novel 1-Hydroxyquinolones with High Anti-Toxoplasma Activity

  摘要：

  All for the treatment of malaria and toxoplasmosis the novel hydroxyquinolones 2-5 were prepared by reaction of aniline and hydroxyaniline, respectively and the beta-ketoesters 10a-c. As products the quinolones 8 and 15, respectively were obtained. Benzylation, oxidation and hydrogenation then led to the desired substances. Compound 2 has a similar anti-malaria activity as the approved drug Atovaquone.

  DOI：

  10.3987/com-10-s(e)9
• 作为产物：
  描述：

  4-benzyloxy-2-dodecyl-6-(triisopropylsilyloxy)quinoline 在 四丁基氟化铵 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.5h， 以90%的产率得到4-benzyloxy-2-dodecylquinolin-6-ol
  参考文献：
  名称：

  Synthesis of Novel 1-Hydroxyquinolones with High Anti-Toxoplasma Activity

  摘要：

  All for the treatment of malaria and toxoplasmosis the novel hydroxyquinolones 2-5 were prepared by reaction of aniline and hydroxyaniline, respectively and the beta-ketoesters 10a-c. As products the quinolones 8 and 15, respectively were obtained. Benzylation, oxidation and hydrogenation then led to the desired substances. Compound 2 has a similar anti-malaria activity as the approved drug Atovaquone.

  DOI：

  10.3987/com-10-s(e)9