3-oxo-decanal | 38975-39-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-oxo-decanal
• 英文别名: 3-Oxodecanal
• CAS: 38975-39-2
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: FPWYXHKGPQQAAG-UHFFFAOYSA-N

物化性质

• 沸点：
  240.8±23.0 °C(Predicted)
• 密度：
  0.905±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  壬烯 在 镍 氢气 、 C.I.酸性橙108 、 溶剂黄146 、 copper(l) chloride 、 sodium nitrite 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 反应 27.0h， 生成 3-oxo-decanal
  参考文献：
  名称：

  Dasaradhi, L.; Rao, S. Jagadishwar; Bhalerao, U.T., Synthetic Communications, 1990, vol. 20, # 18, p. 2799 - 2804

  摘要：

  DOI：

文献信息

• CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME
  申请人：Arvinas, Inc.

  公开号：US20180215731A1

  公开（公告）日：2018-08-02

  The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

  该描述涉及cereblon E3连接酶结合化合物，包括包含相同成分的双功能化合物，这些化合物作为靶向泛素化的调节剂具有实用价值，尤其是抑制剂，可降解和/或以其他方式抑制根据本公开的双功能化合物。特别是，该描述提供了化合物，其一端含有与cereblon E3泛素连接酶结合的配体，另一端含有与目标蛋白结合的部分，使目标蛋白位于泛素连接酶附近以降解（和抑制）该蛋白。可以合成表现出广泛药理活性的化合物，与几乎所有类型的靶向多肽的降解/抑制一致。
• [EN] NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION<br/>[FR] NOUVEAUX DÉRIVÉS DE PIPÉRAZINE ET PIPÉRIDINE, LEUR SYNTHÈSE ET UTILISATION ASSOCIÉE POUR INHIBER L'OLIGOMÉRISATION DE VDAC, L'APOPTOSE ET LE DYSFONCTIONNEMENT MITOCHONDRIAL
  申请人：THE NAT INST FOR BIOTECHNOLOGY IN THE NEGEV LTD

  公开号：WO2017046794A1

  公开（公告）日：2017-03-23

  Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.

  本文提供了哌嗪和哌啶衍生物，它们的合成以及在抑制VDAC寡聚化、凋亡和线粒体功能障碍中的用途。同时提供了与这些过程相关的疾病的治疗方法，例如阿尔茨海默病。
• [EN] PROCESSES FOR THE PREPARATION OF AZD5363 AND NOVEL INTERMEDIATE USED THEREIN<br/>[FR] PROCÉDÉS DE PRÉPARATION D'AZD5363 ET NOUVEL INTERMÉDIAIRE UTILISÉ DANS CES DERNIERS
  申请人：ASTRAZENECA AB

  公开号：WO2015181532A1

  公开（公告）日：2015-12-03

  There is provided a process for the preparation of AZD5363, or a salt of AZD5363, comprising: (a) the reaction of 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-l,8- diazaspiro[4.5]decane-2,4-dione: or a salt thereof, with (S)-3-amino-3-(4-chlorophenyl)propan-1-ol, or a salt thereof, in the presence of base; and (b) either isolating AZD5363 or isolating AZD5363 as a salt. 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione is provided and is prepared by reacting 4-(alkyloxycarbonylamino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperidine-4-carboxylic acid, or a salt thereof, with a cyclising agent

  提供一种制备AZD5363或其盐的方法，包括：(a)将8-(7H-吡咯并[2,3-d]嘧啶-4-基)-3-氧杂-1,8-二氮杂螺[4.5]癸烷-2,4-二酮或其盐与(S)-3-氨基-3-(4-氯苯基)丙醇或其盐在碱存在下反应；(b)隔离AZD5363或作为盐隔离AZD5363。提供8-(7H-吡咯并[2,3-d]嘧啶-4-基)-3-氧-1,8-二氮杂螺[4.5]癸烷-2,4-二酮，通过将4-(烷氧羰基氨基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-羧酸或其盐与环化剂反应制备。
• [EN] COMPLEXES OF METAL SALTS OF ORGANIC ACIDS AND BETA-DIKETONES AND METHODS FOR PRODUCING SAME<br/>[FR] COMPLEXES DE SELS METALLIQUES D'ACIDES ORGANIQUES ET DE BETA-DICETONES ET METHODES DE PRODUCTION
  申请人：CROMPTON CORP

  公开号：WO2004005232A1

  公开（公告）日：2004-01-15

  Metal salts of organic acids complexed with β-diketone compounds are multifunctional complexes useful in the formulation of stabilizers for halogenated resins. These complexes may be used jointly with other low toxicity intermediates, such as zinc or magnesium intermediates, to form effective stabilizers that are non-toxic and exhibit better performance than other known stabilizers, including those containing toxic heavy metals such as cadmium or lead. The complex is prepared utilizing a Claisen condensation reaction and precipitation with water and heptane.

  有机酸金属盐与β-二酮化合物形成的复合多功能配合物可用于制备卤代树脂的稳定剂。这些配合物可以与其他低毒性中间体（如锌或镁中间体）联合使用，形成有效的稳定剂，这些稳定剂是无毒的，并且比其他已知的稳定剂表现更好，包括含有有毒重金属如镉或铅的稳定剂。该复合物是通过Claisen缩合反应和水和庚烷的沉淀制备而成。
• FEED CONTAINING CRUDE DRUG
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0761103A1

  公开（公告）日：1997-03-12

  A mixed feed or a feed additive, which comprises Cucurbita Seed, Plantago and Lornicera. Other crude drugs such as Safflower, Licorice, Mabiacao, Pugongying, Houttuynia and Juhua may be compounded in addition to the above crude drugs. For breeding cattle, swine, fowl, Hamachi, and the like, the above-described mixed feed, or the feed additive compounded with the marketed feed may be used. The resistance to diseases of the fed animals is improved, healthy candicidin can be maintained during the breeding, and the meat quality, egg quality, or the like is improved.

  由葫芦籽、车前子和龙葵组成的混合饲料或饲料添加剂。 除上述粗药外，还可复配其他粗药，如红花、甘草、马鞭草、蒲公英、鱼腥草和菊花等。 饲养牛、猪、鸡、滨鸡等，可使用上述混合饲料，或与市售饲料复配的饲料添加剂。 喂养动物的抗病能力得到提高，在养殖过程中可以保持健康的坎迪辛，肉质、蛋质等也得到改善。