3-isopropyl-6-phenethyl-4-phenoxypyridin-2(1H)-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-isopropyl-6-phenethyl-4-phenoxypyridin-2(1H)-one
• 英文别名: 3-isopropyl-6-phenethyl-4-phenoxy-1H-pyridin-2-one；4-phenoxy-6-(2-phenylethyl)-3-propan-2-yl-1H-pyridin-2-one
• 化学式: C₂₂H₂₃NO₂
• 分子量: 333.43
• InChiKey: BNZDDDKUKQLWNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氧代-5-苯基-戊酸乙酯 在 palladium on activated charcoal 、 苄基三乙基氯化铵 、 氨 、 氢气 、 sodium 、 potassium carbonate 、 三氯氧磷 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 、 乙酸酐 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， -78.0~20.0 ℃ 、101.33 kPa 条件下， 反应 178.0h， 生成 3-isopropyl-6-phenethyl-4-phenoxypyridin-2(1H)-one
  参考文献：
  名称：

  Synthesis and biological evaluation of pyridinone analogues as novel potent HIV-1 NNRTIs

  摘要：

  A novel 2-pyridinone scaffold was rationally designed and synthesized based on the active anti-HIV agent 1 (LAM-trans) via an efficient method. The biological results revealed that some target compounds inhibited HIV-1 reverse transcriptase in the lower micromolar concentration range (IC50 0.089-0.68 mu m). Notably, the most promising compound 25b exhibited extremely potent inhibitory activity against HIV-1 replication with an EC50 value of 0.0563 mu M and the viral selectivity index amounted to 3466.8. Molecular modeling studies were performed, and some SARs were rationalized. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.11.012

文献信息

• Synthesis and biological evaluation of pyridinone analogues as novel potent HIV-1 NNRTIs
  作者：Yuanyuan Cao、Yu Zhang、Shaotong Wu、Quanzhi Yang、Xuefeng Sun、Jianxiong Zhao、Fen Pei、Ying Guo、Chao Tian、Zhili Zhang、Haining Wang、Liying Ma、Junyi Liu、Xiaowei Wang

  DOI：10.1016/j.bmc.2014.11.012

  日期：2015.1

  A novel 2-pyridinone scaffold was rationally designed and synthesized based on the active anti-HIV agent 1 (LAM-trans) via an efficient method. The biological results revealed that some target compounds inhibited HIV-1 reverse transcriptase in the lower micromolar concentration range (IC50 0.089-0.68 mu m). Notably, the most promising compound 25b exhibited extremely potent inhibitory activity against HIV-1 replication with an EC50 value of 0.0563 mu M and the viral selectivity index amounted to 3466.8. Molecular modeling studies were performed, and some SARs were rationalized. (C) 2014 Elsevier Ltd. All rights reserved.