(+/-)-2exo,7syn-dimethoxy-norbornane | 13921-80-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (+/-)-2exo,7syn-dimethoxy-norbornane
• 英文别名: (+/-)-2exo,7syn-Dimethoxy-norbornan；exo-syn-2,7-Dimethoxy-bicyclo<2.2.1>heptan；exo-2,syn-7-Dimethoxybicyclo<2,2,1>heptan；exo-5,syn-7-Dimethoxybicyclo<2.2.1>heptan；(1R,2S,4S,7R)-2,7-dimethoxybicyclo[2.2.1]heptane
• CAS: 13921-80-7；34300-07-7；34300-08-8；34300-09-9；99182-94-2
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: ALLRHAONPIINLN-UYXSQOIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.45
• 重原子数：
  11.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2,5-降冰片二烯 在 palladium on activated charcoal 氢气 作用下， 生成 (+/-)-2exo,7syn-dimethoxy-norbornane
  参考文献：
  名称：

  Baggaley,A.J. et al., Journal of the Chemical Society. Perkin transactions I, 1975, p. 1055 - 1059

  摘要：

  DOI：

文献信息

• Electrochemical Syntheses. IV. The Homolytic Methoxylation and Ethoxylation of Olefins by the Anodic Oxidation of Methanol and Ethanol
  作者：Tadao Inoue、Kikuhiko Koyama、Toru Matsuoka、Shigeru Tsutsumi

  DOI：10.1246/bcsj.40.162

  日期：1967.1

  The electrochemical oxidation of methanol and ethanol in the presence of trans-stilbene, cis-stilbene, norbornene, and styrene has been studied. The major gaseous and nongaseous products have been identified and determined, and the corresponding dimethoxylated derivatives and diethoxylated derivatives have been obtained in fairly high yields. The main path by which these products may have arisen has

  已经研究了在反式二苯乙烯、顺二苯乙烯、降冰片烯和苯乙烯存在下甲醇和乙醇的电化学氧化。主要的气态和非气态产物已被鉴定和测定，相应的二甲氧基化衍生物和二乙氧基化衍生物已以相当高的收率获得。已经讨论了这些产物可能产生的主要途径，并且讨论了将甲氧基自由基加成到二苯乙烯的立体化学。已经特别关注主要产物产生于中间自由基阳极氧化成碳正离子的可能性。
• Energy Intake, Body Mass Index, Physical Activity, and the Colorectal Adenoma-Carcinoma Sequence
  作者：Marie-Christine Boutron-Ruault、Pierre Senesse、Sèverine Mèance、Claude Belghiti、Jean Faivre

  DOI：10.1207/s15327914nc391_7

  日期：2001.1

  Little is known about the precise relationship between energy intake, overweight, sedentary lifestyle, and steps in the colorectal adenoma-carcinoma pathway. We studied these parameters within a case-control study. Patients with adenomas < 10 mm (n = 154) or > 10 min (n = 208) were compared with polyp-free controls (n = 426) for determining factors associated with adenoma formation, i.e., observed for small and large adenomas, or with adenoma growth only. Colorectal cancer cases (n = 171) were compared with population controls (n = 309) to determine factors specific to the final stage, cancer. Exercise reduced the risk of cancer [odds ratio (OR) = 0.3, 95% confidence interval (CI) = 0.2-0.5 for high vs. low physical activity] but had little influence on adenomas. High energy intake increased the risk of cancer [OR for 5th vs. 1st quintile (OR5) = 1.6, 95% CI = 0.9-2.9, p = 0.02], but not of adenomas. High body mass index (BMI) significantly increased the risk of large adenomas (OR, = 2.1, 95% CI = 1.2-3.5, p = 0. 02 and OR5 = 1.7, 95% CI = 1.0-3.1, p = 0.25) for large and small adenomas vs. polyp-free controls. Neither height nor weight nor BMI influenced the risk of cancer. Results were unmodified when controlling for dietary risk factors and family history. Energy intake, a sedentary lifestyle, and high BMI were independently associated with a high risk of cancer use for large adenomas, which indicates an effect on promotion of colorectal tumors. These findings suggest that preventive advice regarding these factors should be provided, even late in life, to decrease the risk of colorectal cancer.
• Molecular rearrangements. VI. Rearrangements of 2-chlorobicyclo[2.2.1]hept-2-ene exo-oxide
  作者：Richard N. McDonald、Theodore E. Tabor

  DOI：10.1021/jo01271a071

  日期：1968.5
• DAVIDSON, R. I.;KROPP, P. J., J. ORG. CHEM., 1982, 47, N 10, 1904-1909
  作者：DAVIDSON, R. I.、KROPP, P. J.

  DOI：——

  日期：——