N²-cinnamoylsalicylhydrazide | 64078-75-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: N²-cinnamoylsalicylhydrazide
• 英文别名: N-cinnamoyl-N'-salicyloylhydrazine；2-hydroxy-N'-(3-phenylprop-2-enoyl)benzohydrazide
• CAS: 64078-75-7
• 化学式: C₁₆H₁₄N₂O₃
• 分子量: 282.299
• InChiKey: LODHFNUFVRVKTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  吡啶 、 N²-cinnamoylsalicylhydrazide 、 nickel(II) acetate tetrahydrate 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以95.15%的产率得到
  参考文献：
  名称：

  Synthesis, characterization and antibacterial activity evaluation of trinuclear Ni(II) complexes with N-substituted salicylhydrazide ligands

  摘要：

  Three novel trinuclear Ni(II) complexes, [Ni-3(L-1)(2)(PY)(4)] (1), [Ni-3(L-2)(2)(H2O)(2)DMA)(2)] (2) and [Ni-3(L-3)(2)(PY)(4)] (3), with trianionic pentadentate ligands derived from salicylhydrazide with N-acyl substituents [H3L1 = N-2-crotonoylsalicylhydrazide, H3L2 = N-2-(3,3-dimethylacryloyl)salicylhydrazide, H3L3 = N-2-cinnamoylsalicylhydrazide] were synthesized and characterized by elemental analysis, spectroscopic techniques, like UV-Vis, FT-IR and NMR, molar conductivity and magnetic susceptibility measurements, and single crystal X-ray diffraction. The solid state structures of the complexes reveal the binding modes of the different ligands via ONO donor atoms. Complex 1 crystallises in the triclinic system while complexes 2 and 3 crystallise in the monoclinic system with space groups PT (1) and P2(1)/c (2 and 3). Computational studies were performed using Density Functional Theory (DFT) to obtain physical properties of all three complexes. The ligands and their metal complexes were screened for antibacterial activity to assess their inhibition potential against two Gram positive bacteria; Staphylococcus aureus and Bacillus subtilis and two Gram negative bacteria; Escherichia coli and Pseudomonas aeruginosa by the well diffusion method using gentamicin as a positive control. Antibacterial screening data reveals that the trinuclear Ni(II) complexes have significantly enhanced inhibitory activities compared to the ligands. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2017.01.019
• 作为产物：
  描述：

  、 水杨酰肼 、 肉桂酰氯 在 水 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 9.0h， 以to yield 3 g of N-cinnamoyl-N'-salicyloylhydrazine as white crystals, m.p. 271° C的产率得到N²-cinnamoylsalicylhydrazide
  参考文献：
  名称：

  Olefin polymer composition

  摘要：

  本发明公开了一种稳定的烯烃聚合物组合物，具有抗铜等重金属接触引起的恶化的性能，其中包括100重量份的烯烃聚合物和0.001至5重量份的N-肉桂酰-N'-酰肼衍生物。

  公开号：

  US04052362A1