3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine | 5409-66-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine
• 英文别名: (4c-hydroxy-1-methyl-4t-phenyl-[3r]piperidyl)-phenyl ketone；(4c-Hydroxy-1-methyl-4t-phenyl-[3r]piperidyl)-phenyl-keton；[(3S,4R)-4-hydroxy-1-methyl-4-phenylpiperidin-3-yl]-phenylmethanone
• CAS: 5409-66-5；21499-56-9
• 化学式: C₁₉H₂₁NO₂
• 分子量: 295.381
• InChiKey: TVRFABREAYQAQA-MJGOQNOKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine 在 氢溴酸 作用下， 生成 2-methyl-9-phenyl-2,3-dihydro-1H-indeno[2,1-c]pyridine
  参考文献：
  名称：

  Conformationally-restricted ligands for the histamine H 1 receptor

  摘要：

  Potent H-1-antagonistic activity in a series of novel indeno[2,1-c]pyridines and their 4-arylpiperidinol precursors is reported; one compound shows an in vitro activity four times that of the standard mepyramine that it was screened against. Their Failure to translate this protection to in vivo tests is discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00199-2
• 作为产物：
  描述：

  吖啶橙 在 乙醚 作用下， 生成 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine
  参考文献：
  名称：

  The Preparation of β-Keto Amines by the Mannich Reaction

  摘要：

  DOI：

  10.1021/ja01254a059

文献信息

• Studies on the Mannich Reaction. II. On the Formation of Piperidine Derivatives (2)
  作者：Norito Uchino

  DOI：10.1246/bcsj.32.1012

  日期：1959.10

  consequence of prototropy, and gave the same products as those in the Mannich reaction.2) In the Mannich reaction, piperidine bases are found to be produced.It was concluded that the phenyl vinyl ketone, which was produced by decomposition of the products in the Mannich reaction, was concerned with the formation of these piperidine bases.

  1) 讨论了苯基乙烯基酮与β-苯甲酰乙胺盐酸盐的反应机理。得出结论，苯基乙烯基酮的β-碳原子与β-苯甲酰乙胺盐酸盐结合，攻击了由β-苯甲酰乙胺盐酸盐引起的孤对电子。 2) Mannich 反应生成哌啶碱。 , 与这些哌啶碱的形成有关。
• THE REACTION OF ACETOPHENONE WITH FORMALDEHYDE AND METHYLAMINE HYDROCHLORIDE
  作者：JOHN T. PLATI、WILHELM WENNER

  DOI：10.1021/jo01156a007

  日期：1949.7
• PYRIDINDENE DERIVATIVES. I
  作者：JOHN T. PLATI、WILHELM WENNER

  DOI：10.1021/jo01147a032

  日期：1950.1
• AROMATIZATION OF N-SUBSTITUTED PIPERIDINE COMPOUNDS
  作者：JOHN T. PLATI、WILHELM WENNER

  DOI：10.1021/jo01152a007

  日期：1950.11
• Perhydro[1,3,2]dioxaborinino[5,4-c]pyridine-A New Heterocyclic System
  作者：K. B. Polyanskii、A. N. Andresyuk、A. T. Soldatenkov

  DOI：10.1023/b:rujo.0000010234.19130.81

  日期：2003.9