3-溴-2,6-二甲氧基吡啶 | 13445-16-4

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-溴-2,6-二甲氧基吡啶
• 中文别名: 2,6-二甲氧基-3-溴吡啶
• 英文名称: 3-bromo-2,6-dimethoxypyridine
• CAS: 13445-16-4
• 化学式: C₇H₈BrNO₂
• 分子量: 218.05
• InChiKey: UUTYQBCAEWGFQL-UHFFFAOYSA-N

物化性质

• 沸点：
  224℃
• 密度：
  1.484
• 闪点：
  89℃
• 稳定性/保质期：
  在常温常压下保持稳定，应避免与氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
3-Bromo-2,6-dimethoxypyridine
Product Name:
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405: Store locked up

---

Section 3. Composition/information on ingredients.
3-Bromo-2,6-dimethoxypyridine
Ingredient name:
CAS number: 13445-16-4

---

Section 4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C7H8BrNO2
Molecular weight: 218.0

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-溴-2,6-二甲氧基吡啶 在 正丁基锂 、 异丙基氯化镁 、 碘 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.75h， 以89%的产率得到3-iodo-2,6-dimethoxypyridine
  参考文献：
  名称：

  二丁基（异丙基）镁酸锂（1-）和氯化锂通过卤素-镁交换进行非低温合成功能化的2-甲氧基吡啶

  摘要：

  使用二丁基（异丙基）镁酸锂（1-）和相应的溴或碘类似物制备在3-，5-或6-位官能化的2-甲氧基吡啶和在3-位官能化的2,6-二甲氧基吡啶。非低温条件下的氯化锂。根据在两种镁酸盐之间的选择以及反应介质中氯化锂的存在与否，对程序进行了优化。 吡啶-镁-锂-有机金属试剂

  DOI：

  10.1055/s-0031-1289687
• 作为产物：
  描述：

  2,6-二甲氧基吡啶 在 溴 作用下， 以 四氯化碳 为溶剂， 以76%的产率得到3-溴-2,6-二甲氧基吡啶
  参考文献：
  名称：

  高效手性二吡啶基膦配体的合成、结构表征及其在Ru催化β-酮酯不对称氢化中的应用

  摘要：

  合成了一种新的手性二吡啶基膦配体 Tol-P-Phos，并通过单晶 X 射线衍射测定了 (R)-Tol-P-Phos 氧化物与 (-)-dibenzoyl-l-tartaric acid [(-)-DBT] 复合物的结构。研究发现，Tol-Phos 的钌络合物 Ru(R-Tol-Phos)(C6H6)Cl2 是一种高活性、高对映选择性的催化剂，可用于 δ² 酮酯的不对称氢化反应（对映选择性高达 98.2%）。该催化剂在溶液中也具有空气稳定性。

  DOI：

  10.1055/s-2001-14659

文献信息

• A General, Multimetallic Cross-Ullmann Biheteroaryl Synthesis from Heteroaryl Halides and Heteroaryl Triflates
  作者：Kai Kang、Nathan L. Loud、Tarah A. DiBenedetto、Daniel J. Weix

  DOI：10.1021/jacs.1c10907

  日期：2021.12.29

  medicine and materials science, the synthesis of biheteroaryls by cross-coupling remains challenging. We describe here a new, general approach to biheteroaryls: the Ni- and Pd-catalyzed multimetallic cross-Ullmann coupling of heteroaryl halides with triflates. An array of 5-membered, 6-membered, and fused heteroaryl bromides and chlorides, as well as aryl triflates derived from heterocyclic phenols,

  尽管它们对医学和材料科学很重要，但通过交叉偶联合成双杂芳基仍然具有挑战性。我们在这里描述了一种新的、通用的双杂芳基方法：杂芳基卤化物与三氟甲磺酸酯的 Ni 和 Pd 催化的多金属交叉 Ullmann 偶联。一系列 5 元、6 元和稠合杂芳基溴化物和氯化物，以及衍生自杂环酚的芳基三氟甲磺酸酯，被证明是该反应中可行的底物（62 个示例，平均产率为 63 ± 17%）。这种方法对双杂芳基的普遍性在 10 μmol 规模的 96 孔板格式中得到进一步证明。一组 96 种可能的产品在一组条件下提供了 >90% 的命中率。此外，可以使用配体、添加剂和还原剂的单个“工具箱板”快速优化低产率组合。
• Efficient Diphosphane-Based Catalyst for the Palladium-Catalyzed Suzuki Cross-Coupling Reaction of 3-Pyridylboronic Acids
  作者：Xing-Li Fu、Lei-Lei Wu、Hai-Yan Fu、Hua Chen、Rui-Xiang Li

  DOI：10.1002/ejoc.200900038

  日期：2009.5

  4′-bis(diphenylphosphanyl)-3,3′-bipyridine (P-Phos) has been developed for the Suzuki cross-coupling reaction of pyridylboronic acid with a variety of aryl halides in good to excellent yields, even in the presence of hindered and functional groups. In addition, P-Phos also exhibited high activity in the palladium-catalyzed Suzuki reaction of 2,6-dimethoxypyridylboronic acid in excellent yields with a fast

  已经为铃木交叉偶联开发了一种源自 PdCl2 和 2,2',6,6'-四甲氧基-4,4'-双（二苯基膦酰基）-3,3'-联吡啶（P-Phos）的高活性催化剂体系吡啶基硼酸与各种芳基卤化物的反应，即使在受阻和官能团存在的情况下，也能以良好到极好的收率进行反应。此外，P-Phos 在钯催化的 2,6-二甲氧基吡啶基硼酸的 Suzuki 反应中也表现出高活性，产率高，速度快。还讨论了 P-Phos-钯配合物对这种交叉偶联反应的空间和电子效应。 (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
• Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes
  作者：Indrajit Ghosh、Jagadish Khamrai、Aleksandr Savateev、Nikita Shlapakov、Markus Antonietti、Burkhard König

  DOI：10.1126/science.aaw3254

  日期：2019.7.26

  Two-for-one approach to photoredox In photoredox catalysis, an excited chromophore typically activates a single reactant either by oxidizing or reducing it. Ghosh et al. used a semiconductor catalyst to activate two reactants at once by quenching both an excited electron and the residual positive hole (see the Perspective by Swift). As such, two different reactive carbon or halide fragments could be

  光氧化还原二合一方法 在光氧化还原催化中，激发的发色团通常通过氧化或还原单个反应物来激活它。戈什等人。使用半导体催化剂通过淬灭激发的电子和残留的空穴来同时激活两种反应物（参见 Swift 的观点）。因此，可以将两个不同的反应性碳或卤化物片段附加到芳环上的不同位点。该催化剂还可以耐受氰化物等强亲核试剂，并且可以轻松回收和重复使用。科学，这个问题 p。360; 另见第。320 半导体光催化剂上氧化和还原位点的形成促进了双自由基加成反应。半导体表面上的光激发电子-空穴对可以与两种不同的基材进行氧化还原反应。与传统的电合成类似，主要的氧化还原中间体仅提供单独的氧化和还原产物，或者更罕见地结合成一种加成产物。在这里，我们报告了一种稳定的有机半导体材料，介孔石墨碳氮化物 (mpg-CN)，可以充当可见光光氧化还原催化剂，以协调氧化和还原界面电子转移到两个或三个组件中的两种不同基材。用于芳烃和杂芳烃的直接双重碳氢功能化的系统。mpg-CN
• INDOLE DERIVATIVES AS CRAC MODULATORS
  申请人：Alam Muzaffar

  公开号：US20110071150A1

  公开（公告）日：2011-03-24

  Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 and R 4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).

  公式I的化合物： 或其药用可接受的盐， 其中R1、R2、R3和R4按本文定义。还公开了制造这些化合物的方法以及使用这些化合物治疗与钙释放激活钙通道（CRAC）相关疾病的用途。
• 2-Thiopyrimidinones
  申请人：Carpino Philip A.

  公开号：US20130123230A1

  公开（公告）日：2013-05-16

  Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular conditions.

  髓过氧化物酶抑制剂，含有这种抑制剂的药物组合物以及利用这种抑制剂治疗心血管疾病等的用途。

表征谱图