2-(2-(2-(4-iodophenoxy)ethoxy)ethoxy)ethan-1-ol | 187662-48-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-(2-(4-iodophenoxy)ethoxy)ethoxy)ethan-1-ol
• 英文别名: 2-(2-(2-(4-iodophenoxy)ethoxy)ethoxy)ethanol；2-[2-(2-(4-iodophenoxy)ethoxy)ethoxy]ethanol；2-{2-[2-(4-iodophenoxy)ethoxy]ethoxy}ethanol；2-[2-[2-(4-Iodophenoxy)ethoxy]ethoxy]ethanol
• CAS: 187662-48-2
• 化学式: C₁₂H₁₇IO₄
• 分子量: 352.169
• InChiKey: FKAFMFGXPGWGEG-UHFFFAOYSA-N

物化性质

• 沸点：
  419.8±40.0 °C(Predicted)
• 密度：
  1.542±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-(2-(4-iodophenoxy)ethoxy)ethoxy)ethan-1-ol 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 咪唑 、 ammonium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 4-(4-(2-(2-(2-(tert-butyldimethylsilanyloxy)ethoxy)ethoxy)ethoxy)phenylethynyl)phenylamine
  参考文献：
  名称：

  New Diphenylacetylenes as Probes for Positron Emission Tomographic Imaging of Amyloid Plaques

  摘要：

  A series of F-18 fluoropegylated diphenylacetylenes as probes for binding to A beta plaques were successfully prepared. These relatively rigid acetylenes, 12a, 12b, 14a, and 14b, displayed high binding affinities in postmortem AD brain homogenates (K-i ranging from 1.2 to 2.9 nM). In vivo biodistribution in normal mice exhibited excellent initial brain penetrations (4.42, 4.55, 5.41, and 6.78% dose/g at 2 min for [F-18]12a, 12b, 14a, and 14b, respectively). [F-18]12b and [F-18]14b, with a longer fluoropegylated unit, that is, n = 3, showed faster brain washout at 30 min postinjection (0.42 and 1.57% dose/g) as compared to the shorter fluoropegylated chain ligands, that is, [F-18]12a and [F-18]14a(1.03 and 3.69% dose/g). Autoradiography and homogenate binding confirmed the high binding signal due to A beta plaques. These preliminary results suggest that the novel diphenylacetylenes may be potentially useful for imaging of A beta plaques in the brain of patients with Alzheimer's disease.

  DOI：

  10.1021/jm070090j
• 作为产物：
  描述：

  4-碘苯酚 、 三乙二醇单对甲苯磺酸酯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以64%的产率得到2-(2-(2-(4-iodophenoxy)ethoxy)ethoxy)ethan-1-ol
  参考文献：
  名称：

  Orthogonal switching of self-sorting processes in a stimuli-responsive library of cucurbit[8]uril complexes

  摘要：

  瓜[8]葫芦复合物动态库中的自排序过程可以通过pH和氧化还原刺激进行正交切换。

  DOI：

  10.1039/c7cc05469f

文献信息

• Dimerization of Terminal Arylalkynes in Aqueous Medium by Ruthenium and Acid Promoted (RAP) Catalysis: Acetate‐ Assisted ( <i>sp</i> )C( <i>sp</i> ² )C Bond Formation
  作者：Alessandra Coniglio、Mauro Bassetti、Sergio E. García‐Garrido、José Gimeno

  DOI：10.1002/adsc.201100600

  日期：2012.1

  3‐HO(CH2CH2O)3‐C6H4] in acetic acid/water mixture (1:1, v/v). The reactions proceed for 24 h at room temperature under heterogeneous conditions and afford the dimeric enyne derivatives (E)‐ArCHCHCCAr in high yields and stereoselectivity. The preformed acetato complex [RuCl(η6‐C6Me6)(κ2‐OAc)] catalyzes the dimerization of phenylacetylene under analogous conditions, with rapid substrate conversion. The

  的六甲基苯钌（II）二聚物[的RuCl（μ-Cl）的（η 6 -C 6我6）}] 2（5摩尔％），在一系列钌（II）和钌的测试（IV）配合物，表示对于终端arylalkynesArCCH[Ar为C的二聚化的有效预催化剂源6 ħ 5，3,4,5-（OME）3 c ^ 6 ħ 2，4-MeOC 6 H ^ 4，2-MeOC 6 ħ 4， 4-MEC 6 ħ 4，2,4,5-ME 3 c ^ 6 ħ 2，4-BRC 6 ħ 4，4-CLC 6 ħ 4，4-FC 6 H ^ 4，4-HC（O）C 6 H ^ 4，4-CH 2 CHC 6 ħ 4，3-NCC 6 ħ 4，4-O 2 NC 6 ħ 4，4-ETO 2 C-（CH 2）3 OC 6 H ^ 4，4-HO（CH 2 CH 2 O）3 ç 6 ħ 4，3-HO（CH 2 CH 2 O）3 -C 6H 4 ]在乙酸/水混合物（1：1，v
• Host-guest complexation-triggered chiroptical change of poly(phenylacetylene)s bearing binaphthocrown ether moieties on the main chain
  作者：Ryosuke Sakai、Takafumi Yonekawa、Issei Otsuka、Ryohei Kakuchi、Toshifumi Satoh、Toyoji Kakuchi

  DOI：10.1002/pola.23881

  日期：2010.3.1

  cyclopolymerized with a rhodium catalyst to produce novel poly(phenylacetylene)s bearing a different cavity size of the chiral crown ether in the repeating units (2a–c). In the circular dichroism spectra of the resulting polymers, characteristic Cotton effects were observed in the range from 350 to 500 nm corresponding to the absorption of the conjugated polymer backbone, indicating that the polymers possessed a

  将具有各自氧乙烯链长度的二乙炔单体与铑催化剂进行环聚合，以生产在重复单元（2a – c）中带有不同手性冠醚空腔尺寸的新型聚苯乙炔。在所得聚合物的圆二色性光谱中，观察到特征性的棉花效应在350至500 nm范围内，与共轭聚合物主链的吸收相对应，表明该聚合物具有螺旋结构，并由其诱导了过量的单螺杆感。共价键联的联萘单元。2a – c的宿主-客体复合体非手性宾客根据主链构象的波动产生了手性改变。络合诱导的手性改变的行为基本上由双萘冠醚单元的腔尺寸决定。另外，在2a - c与手性客体络合的情况下，观察到手性响应的螺旋度发生变化，这也取决于冠醚的大小。©2010 Wiley Periodicals，Inc. J Polym Sci A部分：Polym Chem 48：1197-1206，2010年
• 一种二芳香基乙烯衍生物及其制备方法和应用
  申请人：首都医科大学脑重大疾病研究中心（北京脑重大疾病研究院）

  公开号：CN113444036B

  公开（公告）日：2022-10-04

  本发明提供一种二芳香基乙烯衍生物，其结构式如式Ⅰ所示；其中，R1为CH3(甲基)或CD3(氘代甲基)；R2选自C1‑8饱和烷氧基或烷氨基、取代的C2‑6不饱和烷氧基或烷氨基；R3选自或R4选自或且R3和R4中至少一个为含N基团；R5为离去基团；R6为Boc酸酐或H。本发明还提供了上述二芳香基乙烯衍生物的制备方法及应用。本发明提供的二芳香基乙烯衍生物，对Aβ斑块具有更高的亲和力和特异性，且稳定性有所提高，有望提高靶向Aβ斑块相关疾病的诊断。
• Quick Assembly of 1,4-Diphenyltriazoles as Probes Targeting β-Amyloid Aggregates in Alzheimer's Disease
  作者：Wenchao Qu、Mei-Ping Kung、Catherine Hou、Shunichi Oya、Hank F. Kung

  DOI：10.1021/jm070467l

  日期：2007.7.1

  Accumulation of beta-amyloid aggregates (A beta) in the brain is linked to the pathogenesis of Alzheimer's disease (AD). We report a novel approach for producing 1,4-diphenyltriazoles as probes for targeting A beta aggregates in the brain. The imaging probes, a series of substituted tricyclic 1,4-diphenyltriazoles showing excellent binding affinities to A beta aggregates (K-i = 4-30 nM), were conveniently assembled by "click chemistry." Two radioiodinated probes, [I-125]10a and [I-125]10b, and two radiofluorinated probes, [F-18]17a and [F-18]17b, exhibited moderate lipophilicities and showed excellent initial brain penetrations and fast washouts from the normal mouse brain. In vitro autoradiography of postmortem AD brain sections and homogenates showed that these triazoles were binding to A beta plaques. Preliminary results strongly suggest that use of click chemistry, which led to a 1,4-diphenyltriazole-based core, is a highly convenient and flexible approach for assembling novel imaging agents for targeting A beta aggregates in senile plaques in the living human brain.
• WO2008/131148
  申请人：——

  公开号：——

  公开（公告）日：——