sodium alginate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sodium alginate
• 英文别名: sodium alignate；sodium;3,4,5,6-tetrahydroxyoxane-2-carboxylate
• 化学式: C₆H₉O₇*Na
• 分子量: 216.123
• InChiKey: MSXHSNHNTORCAW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -7.46
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  7

ADMET

毒理性

• 相互作用

提出粘性藻酸盐在胃肠道中移动缓慢，允许在小肠的特定部位增强核黄素的吸收。

Proposed that viscous alginate moves slowly thru GI tract, allowing enhanced riboflavin absorption at specialized sites in small intestine.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

向每天接受2微居里(137)Cs和0.8微居里(90)Sr的大鼠饮食中添加普鲁士蓝、藻酸钠和磷酸钙，可以减少骨肉瘤的数量，增加寿命。

Addition of Prussian Blue, sodium alginate, and calcium orthophosphate to diet of rats receiving daily 2 uCi (137)Cs and 0.8 uCi (90)Sr reduced number of osteosarcomas, increased life length.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

藻酸钠具有减少锶吸收的能力...它还可以降低大鼠体内其他放射性二价金属离子的滞留，其顺序为：钡 > 锶 > 锡 > 镉 > 锰 > 锌 > 汞，其中钡的水平降至对照组的3%，镉和锰的水平在三周内降至约50%。

Sodium alginate has the ability to reduce strontium absorption, ... /it/ can also decrease the retention of other radioactive divalent metallic ions in rats in the following order: Barium > Strontium > Tin > Cadmium > Manganese > Zinc > Mercury, with Barium levels being reduced to 3% of control values and Cadmium and Manganese levels, to about 50% in three weeks.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

两组各12只Sprague-Dawley断奶雄性大鼠分别接受对照饮食或含有10%海藻酸钠的饮食（以玉米淀粉为代价）持续8天。在海藻酸钠组中，粪便干物质显著增加。海藻酸钠对钙和锌的吸收没有影响。铁、铬和钴的吸收在海藻酸钠组中显著降低。

Two groups of 12 male weanling Sprague-Dawley rats received a control diet or a diet with 10% Na-alginate, at the expense of corn starch, for 8 days. A marked increase in fecal dry matter was seen in the alginate group. Ca and Zn absorption were not affected by alginate. Absorption of Fe, Cr, and Co were significantly reduced in the alginate group.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

老鼠被喂食了含有磷酸钙和藻酸钠的常规饲料，这些添加剂被分别和同时添加，持续了4-5个月。在此期间，观察了老鼠的生长速度和一些身体组织的视觉及组织学异常。没有观察到毒性效应。对于同时补充这两种添加剂的老鼠，钙的吸收和骨骼保留几乎没有变化，但锶的吸收和保留减少了7倍。

Rats were fed a stock diet supplemented with calcium phosphate and sodium alginate, both separately and simultaneously, over a period of 4-5 months. Observations were made at intervals on the growth rate and on visual and histological abnormalities in some body tissues. No toxic effects were observed. The absorption and skeletal retention of calcium for rats on the combined supplements remained almost unchanged but the absorption and retention of strontium was reduced 7-fold.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

显然...在摄入时没有显著分解或吸收...

Apparently ... not decomposed or absorbed appreciably when ingested ...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

当给予小鼠14C标记的丙二醇藻酸盐或14C标记的丙二醇藻酸...时，未水解的酯和藻酸残基...从胃肠道未被吸收；但是任何水解的丙二醇...被吸收...代谢并排出...单次剂量...1克/千克...通过粪便排出...5天内...

When propyleneglycol (14)C alginate or (14)C propylene glycol alginate ... dosed to mice, unhydrolyzed ester and alginate residue ... unabsorbed from GI tract; but any hydrolyzed propyleneglycol ... absorbed ... metabolized and eliminated ... single dose ... 1 g/kg ... excreted ... feces ... 5 days ...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

... 在5克/千克的剂量下，标签的痕迹仍然存在于直肠中。从掌状海带制备的藻酸盐在大鼠饮食中占每日饮食量的10%时未被吸收。

... After a dose of 5 g/kg, traces of label were still present in rectum. Alginate prepared from laminaria digitata was unabsorbed by rats fed at a level of 10% of their daily diet.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  sodium alginate 在 sulfonic acid catalyst 作用下， 以 水 为溶剂， 生成 戊二酸 、 Mannuronsaeure
  参考文献：
  名称：

  알지네이트 분해 방법

  摘要：

  提供了一种海藻酸分解方法。该海藻酸分解方法包括使用固体酸催化剂在水中进行海藻酸分解反应的步骤，所述固体酸催化剂是具有磺酸作用基的碳催化剂。根据本发明的实施例，可以在不使用硫酸的情况下，环保地分解海藻酸，并通过该海藻酸的分解形成甘露醇酸和葡萄糖醛酸。

  公开号：

  KR20160114448A
• 作为试剂：
  描述：

  硫代乙酰胺 、 copper(II) acetate monohydrate 在 sodium alginate 作用下， 以 水 为溶剂， 反应 1.12h， 生成 copper(II) sulfide
  参考文献：
  名称：

  Preparation and characterization studies of La doped CuS nanospheres by microwave irradiation for high performance supercapacitors

  摘要：

  Lanthanum (Rare earth metal) doped CuS (La@CuS) at different compositions (0%, 1%, 3% and 5% of La) are synthesized by encapsulation of sodium alginate biopolymer using microwave irradiation method. The prepared various compositions of La@CuS are examined by structural characterizations, particle size and identifications of elements from XRD, TEM and EDX spectrum. The surface morphological studies are conformed by SEM and TEM images. Optical properties and characteristics peak are confirmed with UV, FTIR and Raman spectroscopic tools. In addition to that the electrochemical performances are studied using Cyclic Voltammetry (CV), Galvanostatic charge and discharge (GCD) and electrochemical impedance spectroscopy (EIS) investigations. The specific capacitance is found to be 1329 F/g for 5% of La doped CuS nano spheres.

  DOI：

  10.1016/j.physb.2019.08.028

文献信息

• METHODS OF FORMING THREE-DIMENSIONAL TISSUES SCAFFOLDS USING BIOLOGICAL FIBER INKS AND METHODS OF USE THEREOF
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20200330644A1

  公开（公告）日：2020-10-22

  Some embodiments provide method of forming a three-dimensional tissue scaffold that includes extruding a bioink material through a nozzle onto a support while moving the nozzle relative to the support or moving the support relative to the nozzle to form a three-dimensional structure of the bioink material. The bioink material includes a plurality of polymeric fibers, each polymeric fiber having a diameter on a range of 0.1 μm to 20 μm, and each polymeric fiber comprising one or more biocompatible polymers, and a carrier. The method also includes cross-linking or heat fusing at least some of plurality of polymeric fibers in the three-dimensional structure of the bioink material.
• [EN] METHODS OF FORMING THREE-DIMENSIONAL TISSUES SCAFFOLDS USING BIOLOGICAL FIBER INKS AND METHODS OF USE THEREOF<br/>[FR] PROCÉDÉS DE FORMATION D'ÉCHAFAUDAGES TISSULAIRES TRIDIMENSIONNELS À L'AIDE D'ENCRES BIOLOGIQUES À BASE DE FIBRES ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：HARVARD COLLEGE

  公开号：WO2019079292A1

  公开（公告）日：2019-04-25

  Some embodiments provide method of forming a three-dimensional tissue scaffold that includes extruding a bioink material through a nozzle onto a support while moving the nozzle relative to the support or moving the support relative to the nozzle to form a three- dimensional structure of the bioink material. The bioink material includes a plurality of polymeric fibers, each polymeric fiber having a diameter on a range of 0.1 μm to 20 μm, and each polymeric fiber comprising one or more biocompatible polymers, and a carrier. The method also includes cross-linking or heat fusing at least some of plurality of polymeric fibers in the three-dimensional structure of the bioink material.
• 알지네이트 분해 방법
  申请人：KOREA FISHERIES RESOURCES AGENCY 한국수산자원공단(120110312318) Corp. No ▼ 181171-0002742BRN ▼617-82-10767

  公开号：KR20160114448A

  公开（公告）日：2016-10-05

  알지네이트 분해 방법이 제공된다. 상기 알지네이트 분해 방법은, 물에서 고체산 촉매를 이용하여 알지네이트의 분해 반응을 수행하는 단계를 포함하고, 상기 고체산 촉매는 술폰산 작용기를 갖는 카본 촉매이다. 본 발명의 실시예들에 따르면, 황산을 사용하지 않고 친환경적으로 알지네이트를 분해할 수 있고, 상기 알지네이트의 분해에 의해 만루론산과 글루론산이 형성될 수 있다.

  提供了一种海藻酸分解方法。该海藻酸分解方法包括使用固体酸催化剂在水中进行海藻酸分解反应的步骤，所述固体酸催化剂是具有磺酸作用基的碳催化剂。根据本发明的实施例，可以在不使用硫酸的情况下，环保地分解海藻酸，并通过该海藻酸的分解形成甘露醇酸和葡萄糖醛酸。

表征谱图