1-(3-methylbutyl)-1-cyclopentanol | 83926-70-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3-methylbutyl)-1-cyclopentanol
• 英文别名: 1-isopentylcyclopentan-1-ol；1-isopentyl-cyclopentanol；1-Isoamyl-cyclopentanol-(1)；1-(3-Methylbutyl)cyclopentan-1-ol
• CAS: 83926-70-9
• 化学式: C₁₀H₂₀O
• 分子量: 156.268
• InChiKey: NTCGDWSCRCRXQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(3-methylbutyl)-1-cyclopentanol 在 对甲苯磺酸 作用下， 生成 1-(3-甲基丁基)环戊烯
  参考文献：
  名称：

  Chavanne; Becker, Bulletin des Societes Chimiques Belges, 1927, vol. 36, p. 594

  摘要：

  DOI：
• 作为产物：
  描述：

  magnesium,2-methylbutane,bromide 、 环戊酮 在 乙醚 作用下， 生成 1-(3-methylbutyl)-1-cyclopentanol
  参考文献：
  名称：

  Chavanne; Becker, Bulletin des Societes Chimiques Belges, 1927, vol. 36, p. 594

  摘要：

  DOI：

文献信息

• [EN] NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS<br/>[FR] DÉRIVÉS D'ACIDE NAPHT-2-YLACÉTIQUE DANS LE TRAITEMENT DU SIDA
  申请人：GILEAD SCIENCES INC

  公开号：WO2012003497A1

  公开（公告）日：2012-01-05

  The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).

  这项发明提供了如下式（I）的化合物或其盐。该发明还提供了包括如下式I的化合物的药物组合物，制备如下式（I）化合物的方法，用于制备如下式I化合物的有用中间体，以及使用如下式（I）化合物治疗HIV病毒的增殖、治疗艾滋病或延缓哺乳动物发生艾滋病或ARC症状的治疗方法。
• NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES
  申请人：Merck Patent GmbH

  公开号：US20160168090A1

  公开（公告）日：2016-06-16

  The present invention relates to indole compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P2X7-related disorders.

  本发明涉及吲哚化合物及其药用可接受的组合物，用作P2X7拮抗剂，用于治疗与P2X7相关的疾病。
• GaCl₃-Catalyzed Ring-Opening Carbonyl–Olefin Metathesis
  作者：Haley Albright、Hannah L. Vonesh、Marc R. Becker、Brandon W. Alexander、Jacob R. Ludwig、Ren A. Wiscons、Corinna S. Schindler

  DOI：10.1021/acs.orglett.8b02086

  日期：2018.8.17

  The development of a Lewis acid-catalyzed ring-opening cross-metathesis reaction which enables selective access to acyclic, unsaturated ketones as the carbonyl-olefin metathesis products is described. While catalytic amounts of FeCl3 were previously identified as optimal to catalyze ring-closing metathesis reactions, the complementary ring-opening metathesis between cyclic alkenes and carbonyl functionalities

  描述了路易斯酸催化的开环交叉复分解反应的发展，该反应使得能够选择性地获得无环的不饱和酮作为羰基烯烃复分解产物。尽管先前已确定催化量的FeCl3是催化闭环复分解反应的最佳方法，但环状烯烃和羰基官能团之间的互补开环复分解依赖于GaCl3作为优良的路易斯酸催化剂。
• 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
  申请人：Chau Anh

  公开号：US20090075998A1

  公开（公告）日：2009-03-19

  The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

  该发明涵盖了式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗多种疾病或情况引起的疼痛和/或炎症，如骨关节炎，类风湿性关节炎和急性或慢性疼痛。还包括治疗由mPGES-1酶介导的疾病或情况的方法和制药组合物。
• 2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
  申请人：Chau Anh

  公开号：US20070208017A1

  公开（公告）日：2007-09-06

  The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

  本发明涵盖了公式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合成酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病况引起的疼痛和/或炎症，如骨关节炎、类风湿性关节炎和急性或慢性疼痛。还包括治疗由mPGES-1酶介导的疾病或病况的方法和制药组合物。