(E)-2-(4-(4-aminostyryl)-3-cyano-5,5-dimethylfuran-2(5H)-ylidene)malononitrile

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (E)-2-(4-(4-aminostyryl)-3-cyano-5,5-dimethylfuran-2(5H)-ylidene)malononitrile
• 英文别名: 2-[4-[(E)-2-(4-aminophenyl)ethenyl]-3-cyano-5,5-dimethylfuran-2-ylidene]propanedinitrile
• 化学式: C₁₈H₁₄N₄O
• 分子量: 302.335
• InChiKey: RBOGNYZSAOQLPE-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (E)-2-(4-(4-aminostyryl)-3-cyano-5,5-dimethylfuran-2(5H)-ylidene)malononitrile 在 吡啶 、 N,N-二异丙基乙胺 、 三氟乙酸 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 反应 10.5h， 生成 (S,E)-N-(3-cyano-1-((4-(2-(4-cyano-5-(dicyanomethylene)-2,2-dimethyl-2,5-dihydrofuran-3-yl)vinyl)phenyl)amino)-1-oxopropan-2-yl)myristamide
  参考文献：
  名称：

  CN115490654

  摘要：

  公开号：
• 作为产物：
  描述：

  3-羟基-3-甲基-2-丁酮 在 sodium hydroxide 、 乙醇 、 lithium 作用下， 以 乙醇 为溶剂， 反应 22.0h， 生成 (E)-2-(4-(4-aminostyryl)-3-cyano-5,5-dimethylfuran-2(5H)-ylidene)malononitrile
  参考文献：
  名称：

  Star-Shaped Azo-Based Dipolar Chromophores:  Design, Synthesis, Matrix Compatibility, and Electro-optic Activity

  摘要：

  Three new azo-benzene-based push-pull chromophores with dendritic architecture were synthesized as active materials for electro-optic applications. These chromophores were synthesized in six or seven synthetic steps with an overall yield of around 80% per step and high purity. UV-vis spectroscopy showed significant influence of the transient dipole moment on the observed r(33) values, The chromophores were stable to photochemical oxidation in ambient light and air. The electrical poling conditions were optimized for each chromophore as the T-g of the composite material varied significantly. The highest EO coefficient achieved was 22-25 pm/V at 1550 nm wavelength. STEM analysis of the blends enabled the correlation of the activity of these large chromophores with the blend morphology. An amorphous polycarbonate host effectively disperses the chromophores in 2-20 nm aggregates in the active materials. However, macrophase separation into 200-500 nm aggregates was observed in a methacrylate host matrix.

  DOI：

  10.1021/ja039768k

文献信息

• Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems
  申请人：Tweg Robert J.

  公开号：US20100029952A1

  公开（公告）日：2010-02-04

  Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.

  从可光活化的叠氮-π-受体荧光发色团或从叠氮-π-受体荧光发色团与烯烃或炔烃的热反应中衍生的荧光色团被披露。还披露了从炔烃-π-受体荧光发色团与叠氮的热反应中衍生的荧光色团。这些荧光色团可以很容易地被光激活，并可用于标记生物分子，并在活细胞中以单分子水平进行成像。
• Chemical Reporters of Protein Acylation
  申请人：HANG HOWARD C.

  公开号：US20100203647A1

  公开（公告）日：2010-08-12

  Methods and kits for detecting acylated proteins produced by cells that have been cultured or by cells within an organism are provided. Also provided are methods and kits for detecting acylated proteins produced by cells where affinity purification tags are that facilitate detection are used. Compounds useful for the detection of acylated proteins are also provided.

  提供了用于检测已被培养的细胞产生的酰化蛋白或生物体内细胞产生的酰化蛋白的方法和试剂盒。还提供了用于检测已使用亲和纯化标签的细胞产生的酰化蛋白的方法和试剂盒，以便进行检测。还提供了用于检测酰化蛋白的化合物。
• Clickable fluorescent dyes for multimodal bioorthogonal imaging
  作者：Lun K. Tsou、Mingzi M. Zhang、Howard C. Hang

  DOI：10.1039/b917119n

  日期：——

  Bioorthogonal ligation with functionalized fluorescent dyes enables visualization of nuclei acids, proteins and metabolites in biological systems. Bright and modular azide- and alkyne-functionalized dyes are therefore needed to expand the fluorescence imaging capabilities of bioorthogonal ligation methods. We describe the concise synthesis of clickable fluorescent dyes based on 2-dicyanomethylene-3-cyano-2,5-dihydrofuran fluorophores and demonstrate their utility for multicolor imaging of azide- and alkyne-modified proteins as well as FRET studies.

  使用功能化荧光染料进行生物正交连接可以实现生物系统中核酸、蛋白质和代谢物的可视化。因此，需要明亮且模块化的叠氮化物和炔烃官能化染料来扩展生物正交连接方法的荧光成像能力。我们描述了基于 2-二氰亚甲基-3-氰基-2,5-二氢呋喃荧光团的可点击荧光染料的简明合成，并证明了它们在叠氮化物和炔烃修饰蛋白质的多色成像以及 FRET 研究中的实用性。
• METHODS OF DETECTING MYELIN BASIC PROTEIN
  申请人：GENERAL ELECTRIC COMPANY

  公开号：US20140154178A1

  公开（公告）日：2014-06-05

  A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.

  提供了一种检测髓鞘碱性蛋白的方法和试剂盒。该方法包括向患有或有风险患上髓鞘相关神经病的受试者施用结合到髓鞘碱性蛋白（MBP）的试剂，并通过检测附着在受试者身上的试剂来确定髓鞘形成情况。受试者中试剂的存在量表明了髓鞘相关神经病的存在。还提供了一种量化组织样本中MBP存在量的方法，其中该方法包括将组织样本与相同的试剂接触，检测组织样本中存在的试剂，并量化组织样本中存在的试剂的数量。
• FLUOROGENIC COMPOUNDS CONVERTED TO FLUOROPHORES BY PHOTOCHEMICAL OR CHEMICAL MEANS AND THEIR USE IN BIOLOGICAL SYSTEMS
  申请人：TWIEG ROBERT J.

  公开号：US20120190098A1

  公开（公告）日：2012-07-26

  Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.

  本发明揭示了从光活化偶氮-π-受体荧光原子或从偶氮-π-受体荧光原子与烯烃或炔烃进行热反应中得到的荧光原子。还揭示了从炔基-π-受体荧光原子与偶氮进行热反应中得到的荧光原子。这些荧光原子可以轻松地被光激活，并可用于标记生物分子，并在单分子水平上在活细胞中成像。