1-[4-[2-(4-乙酰基苯基)苯基]苯基]乙酮 | 93232-29-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-[4-[2-(4-乙酰基苯基)苯基]苯基]乙酮
• 中文别名: 4,4′-二乙酰邻三联苯
• 英文名称: 4,4’-diacetyl-o-terphenyl
• 英文别名: 4,4'-diacetyl-o-terphenyl；1,2-di(4-acetylphenyl)benzene；1-[4-[2-(4-Acetylphenyl)phenyl]phenyl]ethanone
• CAS: 93232-29-2
• 化学式: C₂₂H₁₈O₂
• 分子量: 314.384
• InChiKey: RTRNMGWRIXQOLH-UHFFFAOYSA-N

物化性质

• 沸点：
  452.1±25.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[4-[2-(4-乙酰基苯基)苯基]苯基]乙酮 在 氯磺酸 、 4-二甲氨基吡啶 、 sodium methylate 、 三乙胺 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 4.34h， 生成 4,4'-bis(1'',1'',1'',2'',2'',3'',3''-heptafluoro-4'',6''-hexanedion-6''-yl) N-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl)-o-terphenyl-sulfonamide
  参考文献：
  名称：

  A novel biocompatible europium ligand for sensitive time-gated immunodetection

  摘要：

  我们描述了一种新型亲水衍生物的合成，该衍生物是四齿β-二酮镧配体，用于制备针对贾第鞭毛虫囊蚴的免疫结合探针。我们使用了门控自同步荧光探测器（GALD）来获得细胞的高质量延迟荧光图像，比以往报道的速度快30倍。

  DOI：

  10.1039/c5cc06811h
• 作为产物：
  描述：

  邻三联苯 、 乙酸酐 在 三氯化铝 作用下， 以 二硫化碳 为溶剂， 以68%的产率得到1-[4-[2-(4-乙酰基苯基)苯基]苯基]乙酮
  参考文献：
  名称：

  Voegtle, Fritz; Mayenfels, Peter; Luppertz, Friedhelm, Synthesis, 1984, # 7, p. 580 - 582

  摘要：

  DOI：

文献信息

• Platinum-catalysed diborylation of arynes: synthesis and reaction of 1,2-diborylarenes
  作者：Hiroto Yoshida、Kengo Okada、Shota Kawashima、Kenji Tanino、Joji Ohshita

  DOI：10.1039/b919407j

  日期：——

  Arynes are found to be facilely inserted into bis(pinacolato)diboron by using a platinum–isocyanide catalyst, affording diverse 1,2-diborylarenes, which can be converted into o-terphenyls via Suzuki–Miyaura coupling reaction.

  研究发现，使用铂-异氰化物催化剂可以轻松将烯插入双（松香酸酯）二硼化合物中，生成多种1,2-二硼基芳烃，这些化合物可以通过铃木-宫浦偶联反应转化为邻三联苯。
• A New Tetradentate β-Diketonate−Europium Chelate That Can Be Covalently Bound to Proteins for Time-Resolved Fluoroimmunoassay
  作者：Jingli Yuan、Kazuko Matsumoto、Hiroko Kimura

  DOI：10.1021/ac970936z

  日期：1998.2.1

  A new chlorosulfonylated tetradentate β-diketone, 4,4‘-bis(1‘‘,1‘‘,1‘‘,2‘‘,2‘‘,3‘‘,3‘‘-heptafluoro-4‘‘,6‘‘-hexanedion-6‘‘-yl)chlorosulfo-o-terphenyl (BHHCT), was synthesized as a chelating label for Eu3+. BHHCT can be covalently bound to proteins under mild conditions and forms a strongly fluorescent chelate with Eu3+. Bovine serum albumin (BSA) and streptavidin (SA) were labeled with BHHCH−Eu3+, and the latter was used for time-resolved fluoroimmunoassay of α-fetoprotein (AFP) in human sera. A remarkably high sensitivity was obtained, with a detection limit of 4.1 × 10-3 pg/mL, which corresponds to an improvement of about 4−5 orders of magnitude, compared to those of all conventional immunoassays including fluoroimmunoassay, enzyme immunoassay, and radioimmunoassay. The high sensitivity has been attained both by strong fluorescence of the present label and by the extremely suppressed background level brought about by the direct labeling of proteins with the β-diketone−Eu3+ complex. A general consideration and ideas are given for designing ideal label ligands for strongly fluorescent Eu3+ complexes.

  合成了一种新的氯磺酰化四齿β-二酮，4,4’-双（1’,1’,1’,2’,2’,3’,3’-七氟-4’,6’-己二酮-6’-基）氯磺酰化-邻联三苯（BHHCT），作为Eu3+的螯合标记物。乙磺酰化四齿β-二酮可以在温和条件下与蛋白质共价结合，并与Eu3+形成强荧光螯合物。牛血清白蛋白（BSA）和链霉亲和素（SA）被BHHCH-Eu3+标记，后者用于人血清中甲种胎儿蛋白（AFP）的解时间分辨荧光免疫分析。获得了非常高的灵敏度，检测限为4.1 × 10-3pg/mL，与所有传统免疫分析方法（包括荧光免疫分析、酶免疫分析和放射免疫分析）相比，灵敏度提高了约4-5个数量级。这种高灵敏度是通过现有标记物的强荧光和通过β-二酮-Eu3+复合物直接标记蛋白质带来的极低的背景水平实现的。给出了设计强荧光Eu3+复合物理想标记配体的一般考虑和思路。
• [EN] LUMINESCENT BIOMOLECULAR COMPLEX AND USE THEREOF<br/>[FR] COMPLEXE BIOMOLÉCULAIRE LUMINESCENT ET SON UTILISATION
  申请人：UNIV MACQUARIE

  公开号：WO2017015693A1

  公开（公告）日：2017-02-02

  The technology relates to biomolecular complex having an antibody-binding protein; a polypeptide linker capable of receiving a luminescence-activating unit; and a luminescence- activating unit. Also disclosed is the use of the biomolecular complex to detect biological target entities.

  这项技术涉及具有抗体结合蛋白的生物分子复合物；能够接收发光激活单元的多肽连接物；以及发光激活单元。还公开了利用这种生物分子复合物来检测生物靶标实体的方法。
• Assay of substance in biological sample using labeled probe
  申请人：Matsumoto Kazuko

  公开号：US06339172B1

  公开（公告）日：2002-01-15

  A method for analyzing an objective substance, comprsing reacting a labeled probe with an objective substance on a biological sample, said probe comprsing a label substance of the formula (I): wherein A1 is an aromatic group, R1 is a hydrogen or —COCH2COCnF2n+1 and n is an integer of 1-6, which is bonded to a probe selected from the group consisting of nucleic acid, nudeic acid binding potein, low molecular ligand and receptor for ligand (except antibody) to give a fluorescent complex, reacting the complex with an objective substance on a biolgical sample and assaying fluorescence of the resultant fluorescent complex, a labeled nucleic acid probe and a labeled nucleotide. According to the method of the present invention, defects such as hindrance of fluorescence due to contaminant substance, low sensitivity and the like can be resolved, thereby enabling analysis on a tissue.

  一种分析客观物质的方法，包括将标记的探针与生物样品上的客观物质反应，所述探针包括式（I）的标记物质：其中A1是芳香族基团，R1是氢或—COCH2COCnF2n+1，n是1-6的整数，与从核酸、核酸结合蛋白、低分子配体和配体受体（除抗体外）的探针中选择的探针结合，以形成荧光复合物，将该复合物与生物样本上的客观物质反应，并测定所得荧光复合物的荧光，标记的核酸探针和标记的核苷酸。根据本发明的方法，可以解决由于污染物质、低灵敏度等缺陷导致的荧光障碍，从而使得可以对组织进行分析。
• POLYMER ELECTROLYTE COMPOSITION, AND POLYMER ELECTROLYTE MEMBRANE, MEMBRANE ELECTRODE COMPLEX AND SOLID POLYMER-TYPE FUEL CELL EACH PRODUCED USING SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20150295262A1

  公开（公告）日：2015-10-15

  The present invention provides: a polymer electrolyte composition which can achieve excellent proton conductivity under slightly humidified conditions, excellent mechanical strength and excellent physical durability, has excellent practicality, and can be produced using a nitrogen-containing additive, wherein the nitrogen-containing additive can prevent the elution of the additive under a strongly acidic atmosphere during the operation of a fuel cell, has excellent chemical stability so as to tolerate a strongly acidic atmosphere, can be dissolved in various general-purpose organic solvents, has superior processability, can be mixed with an ionic-group-containing polymer, can prevent the occurrence of phase separation during the formation of a film, and can prevent the formation of an island-in-sea-like phase separation structure or the occurrence of bleeding out during the formation of a film; and a polymer electrolyte membrane, a membrane electrode assembly and a polymer electrolyte fuel cell, each of which is produced using the polymer electrolyte composition. The polymer electrolyte composition according to the present invention comprises at least an ionic-group-containing polymer (A) and a nitrogen-containing additive (B), said polymer electrolyte composition being characterized in that the nitrogen-containing additive (B) is represented by a specific structural formula.

  本发明提供了一种聚合物电解质组成物，该组成物在轻微湿润条件下能够实现优异的质子导电性能、优异的机械强度和优异的物理耐久性，具有优异的实用性，并且可以使用含氮添加剂进行制备，其中，该含氮添加剂可以在燃料电池运行时防止添加剂在强酸性气氛下析出，具有优异的化学稳定性以耐受强酸性气氛，可以溶解在各种通用有机溶剂中，具有优越的加工性能，可以与含离子基聚合物混合，并且可以防止在膜形成期间发生相分离，并且可以防止在膜形成期间形成类似于海岛-海洋的相分离结构或者出现出血现象；以及使用该聚合物电解质组成物制备的聚合物电解质膜、膜电极组件和聚合物电解质燃料电池。本发明的聚合物电解质组成物包括至少一种含离子基的聚合物(A)和一种含氮添加剂(B)，所述聚合物电解质组成物的特点是该含氮添加剂(B)由一种特定的结构式表示。