(1R)-3endo-hydroxy-4,7,7-trimethyl-norbornane-2exo-carboxylic acid | 1174926-87-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R)-3endo-hydroxy-4,7,7-trimethyl-norbornane-2exo-carboxylic acid
• 英文别名: (1R)-3endo-Hydroxy-4,7,7-trimethyl-norbornan-2exo-carbonsaeure；(1R)-3endo-Hydroxy-4,7,7-trimethyl-norbornan-carbonsaeure-(2exo)；(1R,2R,3S,4R)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptane-2-carboxylic acid
• CAS: 1174926-87-4
• 化学式: C₁₁H₁₈O₃
• 分子量: 198.262
• InChiKey: GQGMGCVFWBFOAZ-LEQIOUOKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1R)-3endo-hydroxy-4,7,7-trimethyl-norbornane-2exo-carboxylic acid 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 (1R)-3exo-hydroxymethyl-1,7,7-trimethyl-norbornane-2endo-ol
  参考文献：
  名称：

  Avela, Annales Academiae Scientiarum Fennicae, Series A2: Chemica, 1956, # 77, p. 72

  摘要：

  DOI：
• 作为产物：
  描述：

  樟脑 在 potassium carbonate 、 sodium amide 、 苯 作用下， 生成 (1R)-3endo-hydroxy-4,7,7-trimethyl-norbornane-2exo-carboxylic acid
  参考文献：
  名称：

  Bredt, Journal fur praktische Chemie (Leipzig 1954), 1922, vol. <2> 104, p. 12

  摘要：

  DOI：

文献信息

• Bredt; Sandkuhl, Justus Liebigs Annalen der Chemie, 1909, vol. 366, p. 68 Anm.
  作者：Bredt、Sandkuhl

  DOI：——

  日期：——
• Rupe; Brin, Helvetica Chimica Acta, 1924, vol. 7, p. 552
  作者：Rupe、Brin

  DOI：——

  日期：——
• Conservative treatment of Garden stage I femoral neck fracture in elderly patients
  作者：J. Tanaka、N. Seki、F. Tokimura、Y. Hayashi

  DOI：10.1007/s004020100318

  日期：2002.1

  We reviewed 38 patients aged 65 years and older with fresh Garden stage I femoral neck fractures treated nonsurgically to determine factors that influence fracture union. The mean follow-up period was 20 (range 6-86) months. Twenty-three (61%) fractures united within 6 months after injury, while 15 (39%) failed to unite. The percentage of united fractures was considerably higher (p<0.01) in patients who began bed-to-wheelchair transfer training 14 days or later after injury than in those who began training within 13 days. The incidence of union was considerably higher (p<0.05) in patients who began ambulation 20 days or later after injury than in those who began within 19 days. There was no statistical difference in the amount of valgus or retroversion of the femoral head between patients whose fractures united and those whose fractures did not. Patients without severe dementia regained the ability to walk significantly more frequently than did patients with severe dementia (p<0.05).
• Rupe, Justus Liebigs Annalen der Chemie, 1924, vol. 440, p. 232
  作者：Rupe

  DOI：——

  日期：——
• Bredt; Sandkuhl, Justus Liebigs Annalen der Chemie, 1909, vol. 366, p. 31
  作者：Bredt、Sandkuhl

  DOI：——

  日期：——