2-phenoxy-4-methyl-6-methoxyquinoline | 359784-21-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-phenoxy-4-methyl-6-methoxyquinoline
• 英文别名: 6-methoxy-4-methyl-2-phenoxy-quinoline；6-Methoxy-4-methyl-2-phenoxy-chinolin；6-Methoxy-4-methyl-2-phenoxyquinoline；6-methoxy-4-methyl-2-phenoxyquinoline
• CAS: 359784-21-7
• 化学式: C₁₇H₁₅NO₂
• 分子量: 265.312
• InChiKey: AMZGVSFXWHIILR-UHFFFAOYSA-N

物化性质

• 沸点：
  416.9±40.0 °C(Predicted)
• 密度：
  1.165±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-phenoxy-4-methyl-6-methoxyquinoline 在 sodium hydroxide 、 sodium periodate 、 四氧化锇 、 草酰氯 、 氨 、 silver nitrate 、 zinc(II) chloride 作用下， 以 乙醚 为溶剂， 反应 68.0h， 生成 2-(6-Methoxy-2-phenoxy-quinolin-4-yl)-acetamide
  参考文献：
  名称：

  Quinoline-4-acetamides as sPLA2 inhibitors

  摘要：

  Quinoline-4-acetamides were designed as potential phospholipase Al inhibitors by structural based method and synthesized. The chemical structures of the obtained compounds were confirmed by elemental analyses, H-1 NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certain inhibition to sPLA(2). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00229-3
• 作为产物：
  描述：

  乙酰基乙酰对甲氧基苯胺 在 氢氧化钾 、 硫酸 、 三氯氧磷 作用下， 反应 6.5h， 生成 2-phenoxy-4-methyl-6-methoxyquinoline
  参考文献：
  名称：

  Quinoline-4-acetamides as sPLA2 inhibitors

  摘要：

  Quinoline-4-acetamides were designed as potential phospholipase Al inhibitors by structural based method and synthesized. The chemical structures of the obtained compounds were confirmed by elemental analyses, H-1 NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certain inhibition to sPLA(2). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00229-3

文献信息

• 65. The reaction of 4-chloroquinaldines and of 2-chlorolepidines with ammonia, and the preparation of the corresponding phenyl ethers
  作者：O. G. Backeberg、J. L. C. Marais

  DOI：10.1039/jr9420000381

  日期：——
• Quinoline-4-acetamides as sPLA2 inhibitors
  作者：Ying Liu、Yabing Feng、Renxiao Wang、Ying Gao、Luhua Lai

  DOI：10.1016/s0960-894x(01)00229-3

  日期：2001.7

  Quinoline-4-acetamides were designed as potential phospholipase Al inhibitors by structural based method and synthesized. The chemical structures of the obtained compounds were confirmed by elemental analyses, H-1 NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certain inhibition to sPLA(2). (C) 2001 Elsevier Science Ltd. All rights reserved.