trideca-O-acetyl-α-maltotetraosyl bromide | 127264-52-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trideca-O-acetyl-α-maltotetraosyl bromide
• CAS: 127264-52-2
• 化学式: C₅₀H₆₇BrO₃₃
• 分子量: 1275.97
• InChiKey: BGSJSSCVVXAFMJ-VWQHICRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.93
• 重原子数：
  84.0
• 可旋转键数：
  23.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  406.51
• 氢给体数：
  0.0
• 氢受体数：
  33.0

反应信息

• 作为反应物：
  描述：

  trideca-O-acetyl-α-maltotetraosyl bromide 在 吡啶 、 sodium methylate 、 silver carbonate 作用下， 以 甲醇 为溶剂， 反应 26.5h， 生成 o-chloro-p-nitrophenyl β-maltotetraoside
  参考文献：
  名称：

  基于环糊精的α-淀粉酶发色底物的合成

  摘要：

  摘要一锅乙酰化和随后部分乙酰化的α-，β-和γ-环糊精分别导致结晶的过乙酰化麦芽六糖，-庚糖和-八糖。β-环糊精的长时间乙酰水解得到乙酰化的麦芽低聚糖的混合物，从中分离出过乙酰化的麦芽三糖，-四糖和-戊糖。将乙酰化的低聚糖转化为α-乙酰溴衍生物，然后转化为4-硝基苯基和2-氯-4-硝基苯基β-糖苷。由4-硝基苯基糖苷制备4，6-O-亚苄基衍生物，其与游离糖苷一起用作猪胰腺α-淀粉酶的底物。一锅乙酰化并随后部分环糊精乙酰化，导致过乙酰化的麦芽低聚体（dp 3-8），

  DOI：

  10.1016/s0008-6215(97)00187-0
• 作为产物：
  描述：

  2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl-(1->4)-2,3,6-tri-O-acetyl-α-D-glucopyranosyl-(1->4)-2,3,6-tri-O-acetyl-α-D-glucopyranosyl-(1->4)-1,2,3,6-tetra-O-acetyl-D-glucopyranose 在 氢溴酸 、 乙酸酐 、 溶剂黄146 作用下， 反应 3.0h， 生成 trideca-O-acetyl-α-maltotetraosyl bromide
  参考文献：
  名称：

  Synthetic studies of bi-fluorescence-labeled maltooligosaccharides as substrates for α-amylase on the basis of fluorescence resonance energy transfer (FRET)

  摘要：

  A series of bi-fluorescence-labeled maltooligosaccharides that lead to fluorescence resonance energy transfer (FRET) was systematically synthesized. Effective FRETs were observed with all of the synthesized probes. Digestion of probes having tetra-, quintet-, hexa- or hepta-saccharidic chain lengths with human saliva alpha-amylase resulted in disappearance of FRET when an excitation wavelength of at 290 nm was used followed by detection at ca. 520 nm due to emission from the dansyl moiety. However, continuous FRET was observed when probes having di- or trisaccharidic chain lengths were used as substrates. In addition to the substrate characteristics based on saccharidic chain length, the reaction rates of digestion for the substrates by amylase were different and also depended on their saccharidic chain length. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.065