邻硝基苯胺对磺酸 | 616-84-2

• 物质功能分类: 化学试剂 - 有机试剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 邻硝基苯胺对磺酸
• 中文别名: 2-硝基苯胺-4-磺酸
• 英文名称: 2-nitroaniline-4-sulfonic acid
• 英文别名: 1-amino-6-nitrobenzene-4-sulphonic acid；3-nitro-4-aminobenzenesulfonic acid；2-nitro-4-sulfonic acid aniline；o-nitro-aniline-p-sulfonic acid；1-amino-2-nitrobenzene-4-sulfonic acid；4-amino-3-nitrobenzene sulfonic acid；4-amino-3-nitrobenzenesulfonic acid
• CAS: 616-84-2
• 化学式: C₆H₆N₂O₅S
• mdl: MFCD00035961
• 分子量: 218.19
• InChiKey: VZLLZDZTQPBHAZ-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C
• 密度：
  1.559 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  135
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2921420090
• 储存条件：
  室温且干燥

SDS

Name:	4-Amino-3-Nitrobenzenesulfonic Acid 97% Material Safety Data Sheet
Synonym:	None Known
CAS:	616-84-2

Section 1 - Chemical Product MSDS Name:4-Amino-3-Nitrobenzenesulfonic Acid 97% Material Safety Data Sheet
Synonym:None Known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
616-84-2	4-Amino-3-Nitrobenzenesulfonic Acid	97%	210-495-7

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 616-84-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H6N2O5S
Molecular Weight: 218.1124

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 616-84-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4-Amino-3-Nitrobenzenesulfonic Acid - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 616-84-2: No information available.
Canada
CAS# 616-84-2 is listed on Canada's NDSL List.
CAS# 616-84-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 616-84-2 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

合成方法

据文献报道，该中间体的合成方法主要有以下几种：4-氯-3-硝基苯磺酸氨解法、以硫酸或氯磺酸作为磺化剂的邻硝基苯胺磺化法。其中，第一种方法需在一定压力下进行，并且工艺较为复杂；第二种方法采用一氯苯和二氯苯混合物为溶剂，以硫酸为磺化剂时产品收率为89.3%，以氯磺酸为磺化剂时收率可达90%。不过，这两种方法使用的溶剂及氯磺酸的价格均相对较高。

用途

该中间体主要用于染料生产中。

反应信息

• 作为反应物：
  描述：

  邻硝基苯胺对磺酸 在 硝酸 作用下， 生成 2,4,N-trinitro-aniline
  参考文献：
  名称：

  Zincke; Kuchenbecker, Justus Liebigs Annalen der Chemie, 1905, vol. 339, p. 226

  摘要：

  DOI：
• 作为产物：
  描述：

  disodium salt of N-nitrosulfanilic acid 在 盐酸 作用下， 反应 20.0h， 生成 邻硝基苯胺对磺酸
  参考文献：
  名称：

  Mayants, A. G.; Pyreseva, K. G.; Gordeichuk, S. S., Journal of Organic Chemistry USSR (English Translation), 1986, vol. 22, # 10, p. 1900 - 1903

  摘要：

  DOI：

文献信息

• Black Trisazo Dyes, Their Preparation And Their Use
  申请人：DFI CHEM GmbH

  公开号：US20170335110A1

  公开（公告）日：2017-11-23

  The present invention provides trisazo dyes of formula (V), wherein A, M and R 1 , R 2 , R 3 , R 4 are as defined in the specification, processes for their preparation, recording liquids and liquid dye preparations containing them and their use in inks as well as processes for applying them and printed articles comprising them.

  本发明提供了式（V）的三偶氮染料，其中A、M和R1、R2、R3、R4如规范中所定义，其制备方法，含有它们的记录液体和液体染料制剂，以及它们在墨水中的使用方法以及应用它们的方法和包括它们的印刷品。
• [EN] WATER SOLUBLE AND WATER FAST DYES FOR INK JET PRINTING<br/>[FR] COLORANTS HYDROSOLUBLES ET SOLIDES À L'EAU POUR L'IMPRESSION PAR JET D'ENCRE
  申请人：ILFORD IMAGING CH GMBH

  公开号：WO2013139485A1

  公开（公告）日：2013-09-26

  The invention relates to azo dyes of desulfo-K-acid [CA: 35400-55-6], their salts, a method for the preparation of these dyes, or salts thereof, a liquid phase comprising at least one of these dyes, a method for applying the liquid phase on a substrate, a printed matter and the use of these dyes in water-based inks for inkjet printing, in writing utensil or dyeing solutions for manufacturing color filters for optical and opto-electronic applications.

  本发明涉及去磺酸K酸偶氮染料[CA: 35400-55-6]，它们的盐，制备这些染料或其盐的方法，至少包含一种这些染料的液相，将液相施加到基底上的方法，印刷品以及这些染料在水基喷墨打印油墨、书写工具或用于制造用于光电子应用的彩色滤光片的染色溶液中的用途。
• Synthesis and Antistaphylococcal Activity of<i>N</i>-Substituted-1<i>H</i>-benzimidazole-sulphonamides
  作者：M. Orhan Püsküllü、Sulhiye Yıldız、Hakan Göker

  DOI：10.1002/ardp.200900199

  日期：2009.11.19

  evaluated for antibacterial activity against Staphylococcus aureus and methicillin‐resistant S. aureus (MRSA). Certain compounds inhibit bacterial growth with low MIC (μg/mL) values. The most active compounds 30, 31, and 32 have the lowest MIC values with 0.39 to 0.19 μg/mL. Among the compounds having sulfonamido moities, 16, 23, and 24 exhibited the strongest antibacterial activity with 1.56 μg/mL MIC values

  合成了一系列 N-取代-1H-苯并咪唑-5(6)-磺酰胺和 3-(5,6-二氯-1H-苯并咪唑-2-基)-N-取代苯磺酰胺并评估其对金黄色葡萄球菌的抗菌活性和耐甲氧西林金黄色葡萄球菌 (MRSA)。某些化合物以低 MIC (μg/mL) 值抑制细菌生长。活性最强的化合物 30、31 和 32 的 MIC 值最低，为 0.39 至 0.19 μg/mL。在具有磺酰氨基部分的化合物中，16、23 和 24 表现出最强的抗菌活性，MIC 值为 1.56 μg/mL。
• Synthetic Clay Excels in ⁹⁰Sr Removal
  作者：Sridhar Komarneni、Tatsuya Kodama、William J. Paulus、C. Carlson

  DOI：10.1557/jmr.2000.0182

  日期：2000.6

  ground water from Hanford site, and fundamental studies of 2Nasup +}yields}Srsup 2+} exchange equilibria revealed that a synthetic clay is extremely selective for sup 90}Sr with a high capacity for uptake. Comparative studies with existing Sr selective ion exchangers clearly revealed that the present synthetic clay exhibited the best performance for sup 90}Sr removal from actual ground water collected

  对来自汉福德场地的实际地下水进行的测试以及对 2Na sup +}产量}Srsup 2+} 交换平衡的基础研究表明，合成粘土对 sup 90}Sr 具有极高的选择性，具有很高的吸收能力。与现有 Sr 选择性离子交换剂的比较研究清楚地表明，本合成粘土表现出从汉福德三个不同位置收集的实际地下水中去除 sup 90}Sr 的最佳性能。这种新型 Sr 离子筛有望用于在意外释放和 sup 90}Sr 污染后净化环境。(c) 2000 材料研究学会。
• Effect of target processing on CoCrPtTa thin-film media
  作者：S. D. Harkness、W. Lewis、M. Bartholomeusz、M. Tsai

  DOI：10.1557/jmr.2000.0401

  日期：2000.12

  The ensuing paper summarizes an investigation on the effect of target microstructural morphology on resultant sputter deposited media magnetic performance. Significant differences in media magnetic coercivity were obtained from Co–Cr–Pt–Ta targets possessing the same chemistry, sputtered under identical conditions, but possessing different microstructural phase and crystallographic texture characteristics. This result was most likely caused by the difference in sputter yields for the Ta-containing phases in the two distinct target microstructures. Results support enhanced chromium segregation yielding a decrease in the intergranuler exchange energy field for the deposited thin films.

  接下来的论文总结了关于靶材微观结构形态对溅射沉积介质磁性能影响的研究。具有相同化学成分的 Co-Cr-Pt-Ta 靶材在相同条件下溅射，但具有不同的微观结构相和晶体纹理特征，因此介质磁矫顽力存在显著差异。造成这一结果的原因很可能是两种不同靶材微观结构中含 Ta 相的溅射产率不同。研究结果表明，铬偏析增强导致沉积薄膜的粒间交换能场降低。