4,4'-亚甲基双(2-异丙基-6-甲基苯胺) | 16298-38-7

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,4'-亚甲基双(2-异丙基-6-甲基苯胺)
• 中文别名: 4,4’-亚甲基双(2-异丙基-6-甲基苯胺)；4,4-亚甲基双(2-异丙基-6-甲基苯胺)
• 英文名称: methylene-1,1-bis(2-isopropyl-6-methylaniline)
• 英文别名: Lonzacure；4,4'-methylenebis[(2-isopropyl-6-methyl)aniline]；4,4'-methylenebis(2-isopropyl-6-methylaniline)；4,4'-Methylen-bis<2-isopropyl-6-methylanilin>；4,4'-Methylen-bis[2-isopropyl-6-methylanilin]；4-[(4-amino-3-methyl-5-propan-2-ylphenyl)methyl]-2-methyl-6-propan-2-ylaniline
• CAS: 16298-38-7
• 化学式: C₂₁H₃₀N₂
• mdl: MFCD00071556
• 分子量: 310.483
• InChiKey: FLNVGZMDLLIECD-UHFFFAOYSA-N

物化性质

• 沸点：
  419.5-423 °C (759.8513 mmHg)
• 密度：
  0.99
• 稳定性/保质期：
  遵照规定使用和储存，则不会发生分解。

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xn,N-Xn,N
• 海关编码：
  2921590090
• 储存条件：
  存放于阴凉干燥处。

SDS

Name:	4 4 -Methylenebis(2-isopropyl-6-methylaniline) 98% (Titr.) Material Safety Data Sheet
Synonym:	4,4'-Methylene-bis-(2-methyl-6(1-methylethyl)benzenamine; Benzenamine, 4,4'-methylenebis[2-methyl-6-(1-methylethyl)]
CAS:	16298-38-7

Section 1 - Chemical Product MSDS Name:4 4 -Methylenebis(2-isopropyl-6-methylaniline) 98% (Titr.) Material Safety Data Sheet
Synonym:4,4'-Methylene-bis-(2-methyl-6(1-methylethyl)benzenamine; Benzenamine, 4,4'-methylenebis[2-methyl-6-(1-methylethyl)]

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
16298-38-7	4,4'-Methylenebis(2-isopropyl-6-methyl	98	unlisted

Hazard Symbols: XN
Risk Phrases: 22

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. May cause chemical conjunctivitis and corneal damage.
Skin:
May cause skin irritation. Absorption into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Ingestion:
May cause irritation of the digestive tract. May cause liver and kidney damage. The toxicological properties of this substance have not been fully investigated. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood.
Overexposure may cause methemoglobinemia.
Inhalation:
May cause respiratory tract irritation. May cause liver and kidney damage. The toxicological properties of this substance have not been fully investigated. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown blood. Inhalation of aniline causes anoxia due to the formation of methemoglobin.
Chronic:
No information found. May cause liver and kidney damage. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis (bluish skin due to deficient oxygenation of blood), rapid heart rate, unconsciousness and possible death.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood.
Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 16298-38-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid or liquid
Color: dark brown
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Not available.
Specific Gravity/Density: .9900g/cm3
Molecular Formula: C21H30N2
Molecular Weight: 310.45

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen, ammonia.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 16298-38-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4,4'-Methylenebis(2-isopropyl-6-methyl aniline) - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 16298-38-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 16298-38-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 16298-38-7 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

制备方法

在聚氨酯（PU）弹性体中作为扩链剂，PU制品具有良好的动态力学性能、水解稳定性和低吸水性。在建筑涂料的环氧树脂（EP）中作为固化剂，制品具有优秀的低吸水性、高的玻璃化转变温度（Tg）和很好的弹性。

用途

该物质在聚氨酯（PU）弹性体中作扩链剂，PU制品表现出良好的动态力学性能、水解稳定性和低吸水性。在建筑涂料的环氧树脂（EP）中作为固化剂，制品具有优秀的低吸水性、高的玻璃化转变温度和很好的弹性。

反应信息

• 作为反应物：
  描述：

  马来酸酐 、 4,4'-亚甲基双(2-异丙基-6-甲基苯胺) 在 甲烷磺酸 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以94%的产率得到1-[4-[[4-(2,5-Dioxopyrrol-1-yl)-3-methyl-5-propan-2-ylphenyl]methyl]-2-methyl-6-propan-2-ylphenyl]pyrrole-2,5-dione
  参考文献：
  名称：

  [EN] AMIDE-EXTENDED CROSSLINKING COMPOUNDS AND METHODS FOR USE THEREOF
  [FR] COMPOSÉS DE RÉTICULATION À EXTENSION D'AMIDE, ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  公开号：

  WO2010019832A3
• 作为产物：
  描述：

  聚合甲醛 、 3-氯-2,6-二乙基苯胺 、 2-甲基-6-异丙苯胺 在 硫酸 作用下， 以 水 、 异丙醇 为溶剂， 反应 6.0h， 生成 4,4’-亚甲基-双-(3-氯-2,6-二乙基苯胺) 、 M-MIPACDEA 、 4,4'-亚甲基双(2-异丙基-6-甲基苯胺)
  参考文献：
  名称：

  NOVEL CURING AGENTS

  摘要：

  本发明涉及一种具有式（I）的树脂固化剂，其中R1至R4各自独立地选择为线性或支链烷基C1至C5，其制备方法，反应产物的混合物以及双组分可固化树脂体系。

  公开号：

  US20120316262A1

文献信息

• CURING AGENTS FOR EPOXY RESINS
  申请人：Dershem Stephen M

  公开号：US20130012620A1

  公开（公告）日：2013-01-10

  The present invention relates to curatives for epoxy resins, and compositions (e.g. adhesives) containing such resins cured using the same methods of preparation and uses therefor. More specifically, the present invention relates to hybrid curatives for epoxy resins comprising both aromatic amine, phenol and/or phenyl ester moieties. A further aspect of the current invention relates to new imidazole catalysts that possess a combination of excellent cure latency as well as low cure temperature onset.

  本发明涉及环氧树脂的硬化剂，以及含有经相同制备方法固化的这种树脂的组合物（例如胶粘剂）及其用途。更具体地，本发明涉及用于环氧树脂的混合硬化剂，包括芳香胺、酚和/或苯酯基团。本发明的另一个方面涉及具有优异固化潜伏期和低固化温度起始点的新咪唑催化剂。
• PROCESS FOR MAKING BENZOXAZINES
  申请人：Cytec Industries Inc.

  公开号：US20160115139A1

  公开（公告）日：2016-04-28

  A synthesis process for making a benzoxazine compound containing at least one benzoxazine unit from aromatic amine containing at least one primary amino group, at least one phenolic compound with at least one ortho-hydrogen, and alkyl formcel. In one embodiment, the aromatic amine is reacted with alkyl formcel to generate an alkoxymethyl intermediate compound. Subsequently, the intermediate compound is reacted with a phenol to generate the benzoxazine compound. In another embodiment, the benzoxazine compound is formed by reacting aromatic amine with alkyl formcel and phenol in one reaction step. Also disclosed is a method for isolating the alkoxymethyl compound formed by reacting aromatic amine with alkyl formcel. The isolated alkoxymethyl compound is useful as a reactant in a subsequent reaction.

  一种合成过程，用于从含有至少一个苯并噁嗪单元的芳香胺，至少含有一个一级氨基的芳香胺，至少含有一个邻位氢的酚类化合物和烷基甲醛制备含有至少一个苯并噁嗪单元的苯并噁嗪化合物。在一种实施方式中，将芳香胺与烷基甲醛反应以生成烷氧甲基中间体化合物。随后，将中间体化合物与酚反应以生成苯并噁嗪化合物。在另一种实施方式中，通过在一个反应步骤中将芳香胺与烷基甲醛和酚反应来形成苯并噁嗪化合物。还公开了一种方法，用于分离由芳香胺与烷基甲醛反应形成的烷氧甲基化合物。分离的烷氧甲基化合物可用作随后反应中的反应物。
• EPOXY COMPOUND, EPOXY RESIN, EPOXY RESIN COMPOSITION, CURED RESIN PRODUCT, PREPREG, FIBER-REINFORCED COMPOSITE MATERIAL, AND PRODUCTION METHODS FOR THESE
  申请人：Teijin Limited

  公开号：US20210292471A1

  公开（公告）日：2021-09-23

  The present invention provides an epoxy compound indicated by chemical formula (1) (in chemical formula (1), X indicates a C1-10 aliphatic hydrocarbon group, R 1 and R 2 each independently indicate one selected from the group consisting of a hydrogen atom, an aliphatic hydrocarbon group, an aromatic group, an alkoxy group, and a halogen atom.)

  本发明提供了一种由化学式（1）表示的环氧化合物（在化学式（1）中，X表示C1-10脂肪烃基，R1和R2分别独立表示从氢原子、脂肪烃基、芳香族基、烷氧基和卤原子中选择的一种。）
• Diimines and secondary diamines
  申请人：Lee Y. John

  公开号：US20060217567A1

  公开（公告）日：2006-09-28

  This invention provides aromatic diimines which have imino hydrocarbylidene groups with at least two carbon atoms, and aromatic secondary diamines which have amino hydrocarbyl groups with at least two carbon atoms. Both the aromatic diimines and the aromatic secondary diamines either are in the form of one phenyl ring, or are in the form of two phenyl rings connected by an alkylene bridge; each position ortho to an imino group or an amino group bears a hydrocarbyl group. When in the form of one phenyl ring, there are two imino groups on the ring or two amino groups on the ring; the imino groups or amino groups are meta or para relative to each other. When in the form of two phenyl rings connected by an alkylene bridge, there is either one imino group or one amino group on each phenyl ring. Also provided are processes for forming diimines and secondary diamines.

  这项发明提供了具有至少两个碳原子的亚烷基亚胺基团的芳香二亚胺和具有至少两个碳原子的氨基亚烷基团的芳香二胺。这些芳香二亚胺和芳香二胺可以是一个苯环的形式，也可以是由烷基桥连接的两个苯环的形式；每个邻位对着亚烷基基团或氨基基团。当以一个苯环的形式时，环上有两个亚胺基团或两个氨基团；亚胺基团或氨基团互为间位或对位。当以由烷基桥连接的两个苯环的形式时，每个苯环上要么有一个亚胺基团，要么有一个氨基基团。还提供了形成二亚胺和二胺的方法。
• Curing agents for epoxy resins
  申请人：Designer Molecules, Inc.

  公开号：US08288591B2

  公开（公告）日：2012-10-16

  A variety of curing agents for epoxy resins and methods for preparation thereof are disclosed, including compounds having the structures of formulas III and IV: wherein each of R1, R2, R3, R4, and R5 is independently selected from the group consisting of H, methyl, ethyl, n-propyl, iso-propyl, a butyl, and phenyl. Epoxy-based compositions including various curing agents are also disclosed. Other epoxy curatives containing amino, phenol, and/or imine groups are disclosed.

  揭示了用于环氧树脂的各种固化剂以及其制备方法，包括具有III和IV式结构的化合物：其中R1、R2、R3、R4和R5中的每一个独立地选自H、甲基、乙基、正丙基、异丙基、丁基和苯基。还揭示了包括各种固化剂的基于环氧的组合物。还揭示了含有氨基、酚基和/或亚胺基固化剂。