(Z)-12-pentadecen-2-one | 1265227-05-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-12-pentadecen-2-one
• 英文别名: (Z)-pentadec-12-en-2-one
• CAS: 1265227-05-1
• 化学式: C₁₅H₂₈O
• 分子量: 224.387
• InChiKey: DUNXJOPMWWRHFV-PLNGDYQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (Z)-12-pentadecen-2-one 、 1-甲基苯唑 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正庚烷 、 乙基苯 为溶剂， 反应 1.5h， 以41%的产率得到1-methyl-2-[(Z)-10'-tridecenyl]-4(1H)-quinolone
  参考文献：
  名称：

  Design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl-4(1H)-quinolones

  摘要：

  A series of 23 new 1-methyl-2-alkenyl-4(1H)quinolones have been synthesized and evaluated in vitro for their antimycobacterial activities against fast growing species of mycobacteria, such as Mycobacterium fortuitum, M. smegmatis and M. phlei. The compounds displayed good to excellent inhibition of the growth of the mycobacterial test strains with improved antimycobacterial activity compared to the hit compound, evocarpine. The most active compounds, which possessed chain length of 11-13 carbons at position-2 displayed potent inhibitory effects with an MIC value of 1.0 mg/L. In a human diploid embryonic lung cell line, MRC-5 cytotoxicity assay, the alkaloids showed weak to moderate cytotoxic activity. Biological evaluation of these evocarpine analogues on the less pathogenic fast growing strains of mycobacteria showed an interesting antimycobacterial profile and provided significant insight into the structure-activity relationships. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.10.060
• 作为产物：
  描述：

  11-溴十一酸 在 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙醚 、 甲苯 为溶剂， 反应 56.0h， 生成 (Z)-12-pentadecen-2-one
  参考文献：
  名称：

  Design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl-4(1H)-quinolones

  摘要：

  A series of 23 new 1-methyl-2-alkenyl-4(1H)quinolones have been synthesized and evaluated in vitro for their antimycobacterial activities against fast growing species of mycobacteria, such as Mycobacterium fortuitum, M. smegmatis and M. phlei. The compounds displayed good to excellent inhibition of the growth of the mycobacterial test strains with improved antimycobacterial activity compared to the hit compound, evocarpine. The most active compounds, which possessed chain length of 11-13 carbons at position-2 displayed potent inhibitory effects with an MIC value of 1.0 mg/L. In a human diploid embryonic lung cell line, MRC-5 cytotoxicity assay, the alkaloids showed weak to moderate cytotoxic activity. Biological evaluation of these evocarpine analogues on the less pathogenic fast growing strains of mycobacteria showed an interesting antimycobacterial profile and provided significant insight into the structure-activity relationships. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.10.060

文献信息

• US20140271537A1
  申请人：——

  公开号：US20140271537A1

  公开（公告）日：2014-09-18
• DEUTERIUM-ENRICHED ALDEHYDES
  申请人：Deuteria Agrochemicals, LLC

  公开号：US20150208651A1

  公开（公告）日：2015-07-30

  The present invention generally relates to deuterium-enriched aldehydes, compositions comprising deuterium-enriched aldehydes, and methods for slowing the rate of aldehyde autoxidation. In one aspect, the present invention provides a composition comprising a compound of structure 1: wherein: there are at least 6×10 18 molecules of the aldehyde and R x is hydrogen, wherein the deuterium isotope in R x is in an amount greater than 0.10 percent of the hydrogen atoms present in R x .
• US9023336B2
  申请人：——

  公开号：US9023336B2

  公开（公告）日：2015-05-05
• US9179670B2
  申请人：——

  公开号：US9179670B2

  公开（公告）日：2015-11-10
• US9713330B1
  申请人：——

  公开号：US9713330B1

  公开（公告）日：2017-07-25