3-methyl-4-methoxypropiophenone | 76805-57-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methyl-4-methoxypropiophenone
• 英文别名: 1-(4-methoxy-3-methylphenyl)propane-1-one；1-(4-methoxy-3-methylphenyl)propan-1-one；2-methyl-4-propionylanisole；4-methoxy-3-methylpropiophenone；1-(4-methoxy-3-methyl-phenyl)-propan-1-one；1-(4-Methoxy-3-methyl-phenyl)-propan-1-on
• CAS: 76805-57-7
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: BTDAUZLVABMUJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methyl-4-methoxypropiophenone 在 三氯化铝 、 Petroleum ether 作用下， 生成 1-(4-羟基-3-甲基苯基)丙烷-1-酮
  参考文献：
  名称：

  Dodds et al., Proceedings of the Royal Society of London. Series B, Biological sciences, 1953, vol. 140, p. 470,480

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基-3-甲基苯甲酸 在 草酰氯 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.5h， 生成 3-methyl-4-methoxypropiophenone
  参考文献：
  名称：

  四唑啉酮化合物及其用途

  摘要：

  本发明提供了一种由式(1)表示的四唑啉酮化合物(其中E表示以下基团E16等；Y表示‑O‑CH2‑等；Q表示以下基团Q46等；R8表示C1‑C6烷基；R3、R30和R31可以相同或不同并且表示氢原子等；A表示任选地具有一个或多个选自P1组的原子或基团的C6‑C16芳基等；R5表示C1‑C3烷基；并且X表示氧原子或硫原子)，并且该四唑啉酮化合物具有优异的防治有害生物的活性。

  公开号：

  CN105636955B

文献信息

• Synthesis and Characterization of AlCl₃ Impregnated Molybdenum Oxide as Heterogeneous Nano-Catalyst for the Friedel-Crafts Acylation Reaction in Ambient Condition
  作者：Arvind H. Jadhav、Amutha Chinnappan、Vishwanath Hiremath、Jeong Gil Seo

  DOI：10.1166/jnn.2015.11253

  日期：2015.10.1

  Aluminum trichloride (AlCl₃) impregnated molybdenum oxide heterogeneous nano-catalyst was prepared by using simple impregnation method. The prepared heterogeneous catalyst was characterized by powder X-ray diffraction, FT-IR spectroscopy, solid-state NMR spectroscopy, SEM imaging, and EDX mapping. The catalytic activity of this protocol was evaluated as heterogeneous catalyst for the Friedel-Crafts acylation reaction at room temperature. The impregnated MoO₄(AlCl₂)₂ catalyst showed tremendous catalytic activity in Friedel-Crafts acylation reaction under solvent-free and mild reaction condition. As a result, 84.0% yield of acyl product with 100% consumption of reactants in 18 h reaction time at room temperature was achieved. The effects of different solvents system with MoO₄(AlCl₂)₂ catalyst in acylation reaction was also investigated. By using optimized reaction condition various acylated derivatives were prepared. In addition, the catalyst was separated by simple filtration process after the reaction and reused several times. Therefore, heterogeneous MoO₄(AlCl₂)₂ catalyst was found environmentally benign catalyst, very convenient, high yielding, and clean method for the Friedel-Crafts acylation reaction under solvent-free and ambient reaction condition.

  氯化铝（AlCl3）浸渍的钼氧化物非均相纳米催化剂是通过简单的浸渍方法制备的。所制备的非均相催化剂通过粉末X射线衍射、傅里叶变换红外光谱、固体核磁共振光谱、扫描电镜成像和能谱分析进行了表征。该方法的催化活性被评估为在室温下作为弗里德尔-克拉夫茨酰化反应的非均相催化剂。浸渍的MoO4(AlCl2)2催化剂在无溶剂和温和反应条件下表现出巨大的催化活性。结果表明，在室温下，18小时反应时间内，酰基产物的产率为84.0％，反应物的消耗率为100％。还研究了在酰化反应中使用MoO4(AlCl2)2催化剂的不同溶剂体系的影响。通过使用优化的反应条件，制备了各种酰化衍生物。此外，反应后通过简单的过滤过程分离催化剂，并多次重复使用。因此，非均相MoO4(AlCl2)2催化剂被发现是一种环境友好的催化剂，非常方便，产率高，是一种无溶剂和环境条件下进行弗里德尔-克拉夫茨酰化反应的清洁方法。
• [EN] BIS-(ARYL/HETEROARYL)-METHYLENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR USE FOR TREATING CANCER<br/>[FR] COMPOSÉS DE BIS(ARYL/HÉTÉROARYL)MÉTHYLÈNE, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR UTILISATION POUR LE TRAITEMENT DU CANCER
  申请人：UNIV MCGILL

  公开号：WO2013091082A1

  公开（公告）日：2013-06-27

  The present disclosure relates to novel bis-(aryl/heteroaryl)-methylene compounds of formula (I) having vitamin D receptor agonist and histone deacetylase (HDAC) inhibitory efficacy as well as to methods for reducing or inhibiting the proliferation of cancer cells or for treating cancer cells.

  本公开涉及具有维生素D受体激动剂和组蛋白去乙酰化酶（HDAC）抑制活性的新型双（芳基/杂芳基）亚甲基化合物（I）的公式，以及用于减少或抑制癌细胞增殖或治疗癌细胞的方法。
• Friedel-Crafts Acylation Reactions Using Esters
  作者：Subhash P. Chavan、Sumanta Garai、Achintya Kumar Dutta、Sourav Pal

  DOI：10.1002/ejoc.201201181

  日期：2012.12

  Intermolecular and intramolecular Friedel–Crafts acylation reactions of various aliphatic and aromatic esters at room temperature with the use of very simple reagents and activating groups in are described. The products were obtained in good yield (60–85 %). The detailed mechanistic pathway was studied by DFT calculations and supported by experimental evidence.

  描述了使用非常简单的试剂和活化基团在室温下各种脂肪族和芳香族酯的分子间和分子内 Friedel-Crafts 酰化反应。产品以良好的收率（60-85%）获得。通过 DFT 计算研究了详细的机械路径，并得到了实验证据的支持。
• Triazine derivatives, a process for preparing the derivatives, and
  申请人：Idemitsu Kosan Company Limited

  公开号：US04680054A1

  公开（公告）日：1987-07-14

  A triazine derivative represented by the general formula: ##STR1## wherein R.sup.1 and R.sup.2 are each an alkyl group having 1 to 4 carbon atoms, and X.sup.1 and X.sup.2 are each a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxyl group having 1 to 4 carbon atoms, or an alkylthio group having 1 to 4 carbon atoms. This invention also provides a process for efficiently preparing said triazine derivative and a herbicide containing said triazine derivative as effective component.

  一种由以下通式表示的三嗪衍生物：##STR1## 其中R.sup.1和R.sup.2分别是具有1到4个碳原子的烷基基团，X.sup.1和X.sup.2分别是卤素原子、具有1到4个碳原子的烷基基团、具有1到4个碳原子的烷氧基基团或具有1到4个碳原子的烷基硫基团。本发明还提供了一种有效制备所述三嗪衍生物的方法和含有所述三嗪衍生物作为有效成分的除草剂。
• AROMATIC COMPOUND AND USES THEREOF
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20170105413A1

  公开（公告）日：2017-04-20

  A pest control agent comprising an aromatic compound represented by formula (1) wherein R 1 represents a halogen atom, etc.; R 3 represents a hydrogen atom, etc.; R 7 represents a C1-C3 alkyl group optionally having one or more halogen atoms, etc.; Z 2 represents a halogen atom, etc.; Z 3 represents a C1-C3 alkyl group optionally having one or more halogen atoms, etc.; and Q represents the following group Q1, Q2, or Q3 has excellent control activity.

  一种杀虫剂，包括由式（1）表示的芳香族化合物，其中R1表示卤素原子等；R3表示氢原子等；R7表示C1-C3烷基，可选地具有一个或多个卤素原子等；Z2表示卤素原子等；Z3表示C1-C3烷基，可选地具有一个或多个卤素原子等；以及Q表示以下的Q1、Q2或Q3基团，具有出色的控制活性。