2-buten-1-ol | 57642-98-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-buten-1-ol
• 英文别名: butenol；methyl-2-propen-3-ol；trans-buten-1-ol；butylene alcohol；n-butenyl alcohol；butenyl alcohol；epoxybutene；1-butenol；n-butenol；butyraldehyde; trans-enol form；1-ethyl-2-hydroxyethylene radical；hydroxypolybutene；epoxy-1-butene；1-Buten-1-ol；(E)-but-1-en-1-ol
• CAS: 57642-98-5
• 化学式: C₄H₈O
• 分子量: 72.1069
• InChiKey: SIIVGPQREKVCOP-ONEGZZNKSA-N

物化性质

• 沸点：
  88.9±13.0 °C(Predicted)
• 密度：
  0.841±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-buten-1-ol 、 ethyl 3-{[(trifluoromethyl)sulfonyl]oxy}-1-methyl-1H-2-indolecarboxylate 在 palladium diacetate 、 三苯基膦 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以20%的产率得到ethyl 2-[2-butenyloxy]-1-methyl-3-oxo-2-indolinecarboxylate
  参考文献：
  名称：

  Synthesis and reactivity of substituted 3-([(Trifluoromethyl)sulfonyl]oxy)-1H-indole-2-carboxylate in palladium-catalyzed reactions

  摘要：

  Palladium-catalysed Suzuki and Stille reactions of substituted 3-indolyltriflate afforded the corresponding 3-substituted indoles. By contrast, the Heck reaction of allyl alcohol with such triflates gave 2-allyloxy-3-oxoindole derivatives rather than the 3-substituted indole products as a result of a nucleophilic attack on an acyliminium intermediate. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00649-8

文献信息

• Novel compositions
  申请人：Sandoz Ltd.

  公开号：US04877899A1

  公开（公告）日：1989-10-31

  Sulfur-substituted alkenyl compounds, synthesis thereof, intermediates therefor, and the use of the compounds to control pests.

  硫化取代的烯基化合物，其合成方法，其中间体，以及这些化合物用于控制害虫的使用。
• Lysosometropic detergent therapeutic agents
  申请人：Merck & Co., Inc.

  公开号：US04719312A1

  公开（公告）日：1988-01-12

  The present invention is concerned with the preparation of lysosomotropic detergent agents and pharmaceutical composition useful in the treatment of cancer. These compounds are amine derivatives having a pK of 3.5 of the general structure ##STR1## in which R.sub.1 is C.sub.8-30 alkyl, C.sub.8-30 -alkenyl, substituted C.sub.4-30 alkyl or substituted C.sub.4-30 -alkenyl; R.sub.2 is hydrogen or C.sub.1-4 alkyl and Y is an electron withdrawing group, to control the pK, selected from trifluoroethyl, and difluoroethyl.

  本发明涉及溶酶体靶向性洗涤剂代理和制备用于癌症治疗的药物组合物。这些化合物是胺衍生物，其pK为3.5，具有一般结构##STR1##其中R.sub.1为C.sub.8-30烷基，C.sub.8-30-烯基，取代的C.sub.4-30烷基或取代的C.sub.4-30-烯基；R.sub.2为氢或C.sub.1-4烷基，Y为选择的用于控制pK的电子吸引基团，从三氟乙基和二氟乙基中选择。
• Halogenated tetraenyl prostaglandin derivatives
  申请人：G. D. Searle & Co.

  公开号：US05177251A1

  公开（公告）日：1993-01-05

  The present invention relates to a novel class of halogenated tetraenyl prostaglandin compounds represented by the following general formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Y is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; R.sub.1 is H or a lower alkyl of 1 to 6 carbons; n is an integer from 0 to 3; m is an integer from 0 to 3 and n+m=3; X is Cl or F provided that when X is Cl, n is 2 and m is 1; R.sub.2 and R.sub.3 are independently H, lower alkyl from 1 to 6 carbons, Cl, --CH.sub.2 Cl, --CH.sub.2 F, --CHCl.sub.2, --CCl.sub.3, or taken together form a cycloalkyl of 3 to 6 carbons; R.sub.4 is H, lower alkyl from 1 to 6 carbons, Cl, F or taken together with R.sub.3 form a cycloalkenyl of 4 to 6 carbons; and provided that at least one of --CH.sub.n X.sub.m, R.sub.2, R.sub.3 and R.sub.4 includes a chlorine or fluorine atom.

  本发明涉及一类新型的卤代四烯基前列腺素化合物，其表示为以下通用式##STR1##或其药学上可接受的盐，其中Y为--CH.dbd.CH--或--CH.sub.2--CH.sub.2--; R.sub.1为H或1至6个碳原子的低碳基; n为0至3的整数; m为0至3的整数且n+m=3; X为Cl或F，但当X为Cl时，n为2且m为1; R.sub.2和R.sub.3独立地为H、1至6个碳原子的低碳基、Cl、--CH.sub.2Cl、--CH.sub.2F、--CHCl.sub.2、--CCl.sub.3，或者一起形成3至6个碳原子的环烷基; R.sub.4为H、1至6个碳原子的低碳基、Cl、F，或者与R.sub.3一起形成4至6个碳原子的环烯基; 并且至少有一个--CH.sub.nX.sub.m、R.sub.2、R.sub.3和R.sub.4中包含氯或氟原子。
• Phenoxyphenyl 1-alkoxy-3-methylbutenyl ethers
  申请人：Ciba-Geigy Corporation

  公开号：US03946084A1

  公开（公告）日：1976-03-23

  Compounds of the formula ##SPC1## Wherein R.sub.1 is C.sub.1 - C.sub.5 -alkyl, C.sub.3 - C.sub.5 -alkenyl or C.sub.3 -alkynyl and Y represents an oxygen atom or the group --CH.sub.2 -- and their use for the control of insects are disclosed.

  本发明公开了式子##SPC1##的化合物，其中R.sub.1为C.sub.1-C.sub.5-烷基，C.sub.3-C.sub.5-烯基或C.sub.3-炔基，Y代表氧原子或基团--CH.sub.2--，以及它们用于控制昆虫的方法。