1,3,4-trichloro-9-oxo-9,10-dihydroacridine-2-carboxamide | 1142207-61-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,3,4-trichloro-9-oxo-9,10-dihydroacridine-2-carboxamide
• 英文别名: 1,3,4-trichloro-9-oxo-10H-acridine-2-carboxamide
• CAS: 1142207-61-1
• 化学式: C₁₄H₇Cl₃N₂O₂
• 分子量: 341.581
• InChiKey: CBSPPWQOPSUHHB-UHFFFAOYSA-N

物化性质

• 熔点：
  251-252 °C
• 沸点：
  422.1±45.0 °C(predicted)
• 密度：
  1.602±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3,4-trichloro-9-oxo-9,10-dihydroacridine-2-carboxamide 生成
  参考文献：
  名称：

  Synthesis of polyhalo acridones as pH-sensitive fluorescence probes

  摘要：

  Polyhalo isophthalonitriles were reacted with substituted anilines and subsequently cyclocondensed in the presence of sulfuric acid to give polyhalo acridones. These polyhalo acridones were proven to be useful as pH-sensitive fluorescent probes for a wide range of acidic and basic conditions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.101
• 作为产物：
  描述：

  百菌清 在 硫酸 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 1,3,4-trichloro-9-oxo-9,10-dihydroacridine-2-carboxamide
  参考文献：
  名称：

  Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives

  摘要：

  一系列多卤基蒽醌杂环化合物被合成并评估其体外抗肿瘤活性。化合物4d、4o、5j和5k显示出良好的抗肿瘤选择性。

  DOI：

  10.1039/c4ra12354a

文献信息

• Synthesis of polyhalo acridones as pH-sensitive fluorescence probes
  作者：Chao Huang、Sheng-Jiao Yan、Yan-Mei Li、Rong Huang、Jun Lin

  DOI：10.1016/j.bmcl.2010.05.101

  日期：2010.8

  Polyhalo isophthalonitriles were reacted with substituted anilines and subsequently cyclocondensed in the presence of sulfuric acid to give polyhalo acridones. These polyhalo acridones were proven to be useful as pH-sensitive fluorescent probes for a wide range of acidic and basic conditions. (C) 2010 Elsevier Ltd. All rights reserved.
• Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives
  作者：Chao Huang、Sheng-Jiao Yan、Xiang-Hui Zeng、Bo Sun、Min-Bo Lan、Jun Lin

  DOI：10.1039/c4ra12354a

  日期：——

  A series of polyhalo acridone heterocyclic compounds were synthesized and evaluated for theirin vitroantitumor activity. Compounds4d,4o,5jand5kshowed good antineoplastic selectivity.

  一系列多卤基蒽醌杂环化合物被合成并评估其体外抗肿瘤活性。化合物4d、4o、5j和5k显示出良好的抗肿瘤选择性。