全氟壬烷 | 375-96-2

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物 - 烃类卤化物
• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 中文名称: 全氟壬烷
• 中文别名: 二十氟壬烷；二十壬烷
• 英文名称: 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-eicosafluorononane
• 英文别名: perfluoro-n-nonane；1-(perfluorobutyl)pentane；n-perfluorononane；perfluorononane；PFN；eicosafluorononane；1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-icosafluorononane
• CAS: 375-96-2
• 化学式: C₉F₂₀
• 分子量: 488.067
• InChiKey: UVWPNDVAQBNQBG-UHFFFAOYSA-N

物化性质

• 熔点：
  -16°C
• 沸点：
  125-126 °C (lit.)
• 密度：
  1.799 g/mL at 25 °C (lit.)
• 闪点：
  125-126°C

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  20

安全信息

• 危险等级：
  6.1(b)
• 危险品标志：
  F
• 安全说明：
  S23
• 危险类别码：
  R23
• WGK Germany：
  3
• 海关编码：
  2903399090
• 包装等级：
  III
• 危险类别：
  6.1(b)
• 危险品运输编号：
  2810
• 储存条件：
  2-8°C

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : Perfluorononane
CAS-No. : 375-96-2
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
Caution - substance not yet tested completely.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Synonyms : Eicosafluorononane
Formula : C9F20
Molecular Weight : 488,06 g/mol

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Section 4. FIRST AID MEASURES
Description of first aid measures
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact
Wash off with soap and plenty of water.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water.
Most important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Hydrogen fluoride
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Avoid breathing vapors, mist or gas.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Normal measures for preventive fire protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
General industrial hygiene practice.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards
such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK
(EU EN 14387) respirator cartridges. Use respirators and components tested and approved under
appropriate government standards such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and 125 - 126 °C
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density 1,799 g/mL at 25 °C
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. May cause skin irritation.
Eyes May cause eye irritation.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available

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Section 16. OTHER INFORMATION
Further information
Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

反应信息

• 作为产物：
  描述：

  正壬烷 在 cobalt (III) fluoride 作用下， 生成 全氟壬烷
  参考文献：
  名称：

  715.有机氟化物。第五部分：三氟化钴对烃类的氟化

  摘要：

  DOI：

  10.1039/jr9500003617
• 作为试剂：
  描述：

  tert-butyl 2-(diallylamino)-phenylcarbamate 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 全氟壬烷 、 甲苯 为溶剂， 反应 0.17h， 以91%的产率得到tert-butyl 2-(2H-pyrrol-1(5H)-yl)-phenylcarbamate
  参考文献：
  名称：

  使用微反应器化学的多步反应

  摘要：

  描述了用于研究涉及 Pd 催化的 Heck 反应和 Ru 催化的闭环复分解的多步合成的微流系统。以连续方式成功提供试剂和催化剂输送允许控制反应参数，从而实现快速优化。Heck 反应在多步程序中的表现不如在单步偶联中那么成功，而闭环复分解在生产用于进一步官能化的所需化合物方面被证明是成功的。

  DOI：

  10.3998/ark.5550190.0012.404

文献信息

• [EN] PROCESS FOR THE PREPARATION OF SEMIFLUORINATED ALKANES USING GRIGNARD REAGENTS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ALCANES SEMIFLUORÉS À L'AIDE DE RÉACTIFS DE GRIGNARD
  申请人：NOVALIQ GMBH

  公开号：WO2018228975A1

  公开（公告）日：2018-12-20

  The present invention provides a method for preparing a compound of formula (I) F-(CF2)n-(CH2)m-Ro (I), wherein n is an integer from 2 to 12, m is an integer from 0 to 7, Ro is a linear or branched saturated alkyl group and o depicts the number of carbon atoms, o is an integer from 1 to 12, and wherein m+o is an integer from 2 to 12; comprising reacting a fluorinated compound of formula (II) F-(CF2)n-(CH2)m-X (II), wherein X is CI, Br, I, MgCl, MgBr, or Mgl, and n and m have the same meaning as in formula (I), with a non-fluorinated compound of formula (III) Ro-Y (III), wherein Y is CI, Br, I, MgCl, MgBr, or Mgl, with the proviso that when X is CI, Br or I, Y is MgCl, MgBr or Mgl, and when X is MgCl, MgBr or Mgl, Y is CI, Br or I, and Ro has the same meaning as in formula (I).

  本发明提供了一种制备式(I)的化合物的方法F-(CF2)n-(CH2)m-Ro (I)，其中n是2到12的整数，m是0到7的整数，Ro是线性或支链饱和烷基基团，o表示碳原子数，o是1到12的整数，且m+o是2到12的整数；包括将式(II)的氟化合物F-(CF2)n-(CH2)m-X (II)与式(III)的非氟化合物Ro-Y (III)反应，其中X为CI、Br、I、MgCl、MgBr或Mgl，n和m的含义与式(I)中相同，Y为CI、Br、I、MgCl、MgBr或Mgl，但当X为CI、Br或I时，Y为MgCl、MgBr或Mgl，当X为MgCl、MgBr或Mgl时，Y为CI、Br或I，Ro的含义与式(I)中相同。
• ONE-STEP CATALYTIC PROCESS FOR THE SYNTHESIS OF ISOCYANATES
  申请人：Serrano Fernandez Luis Francisco

  公开号：US20070293696A1

  公开（公告）日：2007-12-20

  A one-pot process for the synthesis of isocyanates, polyisocyanates or mixtures thereof which includes the steps of: i. preparing a mixture comprising an amine, an alcohol, an oxygen-containing gas, carbon monoxide, a metal complex catalyst selected from the group consisting of macrocyclic complex catalysts and cobalt Shiff base catalysts; and a solvent selected from the group consisting of aliphatic or aromatic halocarbons, perhalogenated alcohols, halogenated ethers, halogenated ketones, perfluorinated hydrocarbons, polymers of chlorotrifluoroethylene having the formula —(CF 2 —CFCl) n wherein n is between 2 and 10, and mixtures thereof; ii. subjecting the resulting mixture to a first heating under pressure; iii. cooling and depressurizing the mixture resulting from the previous step; and iv. subjecting the mixture of the previous step to a second heating to separate out the isocyanate product from the mixture.

  一种一锅法合成异氰酸酯、聚异氰酸酯或其混合物的方法，包括以下步骤：i.准备混合物，包括胺、醇、含氧气体、一氧化碳、从大环配合物催化剂和钴希夫碱催化剂中选择的金属配合物催化剂；以及从脂肪族或芳香族卤代烃、全卤代醇、卤代醚、卤代酮、全氟化烃、具有公式—（CF2—CFCl）n的氯三氟乙烯聚合物中选择的溶剂，其中n在2和10之间，并混合它们；ii.在压力下对所得混合物进行第一次加热；iii.冷却和降压从前一步骤得到的混合物；和iv.对前一步骤的混合物进行第二次加热，以从混合物中分离出异氰酸酯产品。
• One-pot catalytic process for the synthesis of isocyanates
  申请人：REPSOL YPF S.A.

  公开号：EP1870398A1

  公开（公告）日：2007-12-26

  One-pot process for the synthesis of isocyanates, polyisocyanates or mixtures thereof which comprises the steps of: i. preparing a mixture comprising an amine, an alcohol, an oxygen containing gas, carbon monoxide, a metal complex catalyst selected from the group consisting of macrocyclic complex catalysts and cobalt Shiff base catalysts; and a solvent selected from the group consisting of aliphatic or aromatic halocarbons, perhalogenated alcohols, halogenated ethers, halogenated ketones, perfluorinated hydrocarbons, polymers of chlorotrifluoroethylene having the formula -(CF2-CFCl)n wherein n is between 2 and 10, and mixtures thereof; ii. subjecting the resulting mixture to a first heating under pressure; iii. cooling and depressurizing the mixture resulting from the previous step; and iv. subjecting the mixture of the previous step to a second heating to separate out the isocyanate product from the mixture.

  合成异氰酸酯、多异氰酸酯或其混合物的单锅工艺，包括以下步骤： i.制备一种混合物，其中包括胺、醇、含氧气体、一氧化碳、选自大环络 合催化剂和希夫碱钴催化剂组的金属络合催化剂；和一种溶剂，该溶剂选自由脂肪族或芳香族卤化碳、全卤化醇、卤化醚、卤化酮、全氟碳氢化合物、具有式 -(CF2-CFCl)n （其中 n 为 2 至 10）的三氯乙烯聚合物及其混合物组成的组； 将所得混合物进行第一次加压加热 iii. 对上一步产生的混合物进行冷却和减压；以及 iv. 对上一步的混合物进行第二次加热，从混合物中分离出异氰酸酯产品。
• Pharmaceutical composition comprising propofol
  申请人：Novaliq GmbH

  公开号：EP2332525A1

  公开（公告）日：2011-06-15

  The invention provides novel pharmaceutical compositions comprising the active ingredient propofol. Preferably, propofol is dissolved in at least one semifluorinated alkane. The compositions, which are preferably liquid or gel-like, may optionally comprise further excipients. They may be used as fill material in capsules, as buccal or nasal sprays, or as aerosols for pulmonary administration. They are particularly useful for the transmucosal administration of propofol.

  本发明提供了包含活性成分异丙酚的新型药物组合物。异丙酚最好溶解在至少一种半氟化烷烃中。这种组合物最好是液体或凝胶状，也可以选择加入其他辅料。它们可用作胶囊的填充材料、口腔或鼻腔喷雾剂，或用作肺部给药的气雾剂。它们尤其适用于异丙酚的经粘膜给药。
• Internal Tamponade Composition
  申请人：FLUORON GMBH

  公开号：EP2730291A1

  公开（公告）日：2014-05-14

  The present invention relates to a composition for use in the treatment of retinal detachment. In particular, the composition comprises a mixture of at least two oils and one or more semifluorinated alkanes for use as temporary tamponades in the treatment of retinal detachment.

  本发明涉及一种用于治疗视网膜脱落的组合物。特别是，该组合物包含至少两种油和一种或多种半氟化烷烃的混合物，可用作治疗视网膜脱落的临时填塞物。

表征谱图