1-[丁基(甲基)磷酰基]丁烷 | 14062-37-4

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 中文名称: 1-[丁基(甲基)磷酰基]丁烷
• 英文名称: dibutylmethylphosphine oxide
• 英文别名: Di-n-butylmethylphosphinoxid；Dibutyl-methyl-phosphinoxid；Dibutylmethylphosphinoxid；Phosphine oxide, dibutylmethyl-；1-[butyl(methyl)phosphoryl]butane
• CAS: 14062-37-4
• 化学式: C₉H₂₁OP
• 分子量: 176.239
• InChiKey: QFYANQALLDVORQ-UHFFFAOYSA-N

物化性质

• 熔点：
  35 °C
• 沸点：
  181 °C(Press: 2 Torr)
• 密度：
  0.875±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-[丁基(甲基)磷酰基]丁烷 在 硫酸 作用下， 生成 Ethyl-(dibutylphosphinyl)-acetat
  参考文献：
  名称：

  Malevannaya,R.A. et al., Journal of general chemistry of the USSR, 1971, vol. 41, p. 2385 - 2389

  摘要：

  DOI：
• 作为产物：
  描述：

  三丁基膦 生成 1-[丁基(甲基)磷酰基]丁烷
  参考文献：
  名称：

  Ovakimyan, M. Zh.; Basergyan, S. K.; Petrovskii, P. V., Russian Journal of General Chemistry, 1999, vol. 69, # 8, p. 1352 - 1352

  摘要：

  DOI：

文献信息

• The aldo-cis-trans-enolic equilibrium of substituted alkyl formylacetates and alkyl formylmethylphosphonates
  作者：S.T. Yoffe、P.V. Petrovsky、Ye.I. Goryunov、T.V. Yershova、M.I. Kabachnik

  DOI：10.1016/0040-4020(72)80114-5

  日期：1972.1

  A number of substituted ethyl formylacetates and ethyl formylmethylphosphonates were synthesized and their enolization studied by NMR. The ethyl halogen-or cyan)-formylacetates and formylmethylphosphonates exhibited stable trans-enolic forms in solutions. Variation of groupings bonded to the CO or PO groups affect the chelating centre basicity. With higher basicity the cis-enolic form is stabilized

  合成了许多取代的甲酰基乙酸乙酯和甲酰基甲基膦酸乙酯，并通过NMR对其烯醇化进行了研究。卤代乙基或氰基-甲酰基乙酸乙酯和甲酰基甲基膦酸酯在溶液中表现出稳定的反式-烯醇式。结合到CO或PO基团上的基团的变化会影响螯合中心的碱度。在较高的碱度下，顺式-烯醇式稳定，反之亦然。分子间的氢键稳定了含有磷酰基的化合物的反烯醇形式。
• CATALYSTS FOR THE PRODUCTION OF HYDROXY ETHER HYDROCARBONS BY VAPOR PHASE HYDROGENOLYSIS OF CYCLIC ACETALS AND KETALS
  申请人：Devon Thomas James

  公开号：US20120330067A1

  公开（公告）日：2012-12-27

  Catalyst compositions of palladium supported on alumina or zirconium oxide supports having low or no silicon dioxide contents and having a specific surface area or modified with alkali, alkaline earth, or phosphine oxide compounds are selective in a vapor phase hydrogenolysis reaction to convert cyclic acetal compounds and/or cyclic ketal compounds in the presence of hydrogen to their corresponding hydroxy ether hydrocarbon reaction products.

  在氧化铝或氧化锆载体上支撑的钯催化剂组合物，具有低或无二氧化硅含量，并具有特定比表面积或经过碱金属、碱土金属或膦氧化物化合物改性，在氢气存在下对环氧乙醛化合物和/或环酮化合物进行选择性蒸汽相氢解反应，将它们转化为相应的羟基醚烃反应产物。
• PRODUCTION OF HYDROXY ETHER HYDROCARBONS BY VAPOR PHASE HYDROGENOLYSIS OF CYCLIC ACETALS AND KETALS
  申请人：Devon Thomas James

  公开号：US20120330066A1

  公开（公告）日：2012-12-27

  A vapor phase hydrogenolysis reaction to convert cyclic acetal compounds and/or cyclic ketal compounds in the presence of hydrogen to their corresponding hydroxy ether hydrocarbon reaction products using a supported noble metal catalyst. The hydrogenolysis reaction can be carried out in the vapor phase and in the absence of a polyhydroxyl hydrocarbon co-solvent.

  在氢气存在下，使用支持的贵金属催化剂将环缩醛化合物和/或环缩酮化合物转化为相应的羟基醚烃反应产物的气相氢解反应。氢解反应可以在气相中进行，并且不需要多羟基烃共溶剂的存在。
• Selective Hydrogenation Catalyst and Methods of Making and Using Same
  申请人：Cheung Tin-Tack Peter

  公开号：US20100228065A1

  公开（公告）日：2010-09-09

  A composition comprising a supported hydrogenation catalyst comprising palladium and an organophosphorous compound, the supported hydrogenation catalyst being capable of selectively hydrogenating highly unsaturated hydrocarbons to unsaturated hydrocarbons. A method of making a selective hydrogenation catalyst comprising contacting a support with a palladium-containing compound to form a palladium supported composition, contacting the palladium supported composition with an organophosphorus compound to form a catalyst precursor, and reducing the catalyst precursor to form the catalyst. A method of selectively hydrogenating highly unsaturated hydrocarbons to an unsaturated hydrocarbon enriched composition comprising contacting a supported catalyst comprising palladium and an organophosphorous compound with a feed comprising highly unsaturated hydrocarbon under conditions suitable for hydrogenating at least a portion of the highly unsaturated hydrocarbon feed to form the unsaturated hydrocarbon enriched composition.

  一种包括支持的氢化催化剂的组合物，其中氢化催化剂包括钯和有机磷化合物，支持的氢化催化剂能够选择性地将高度不饱和烃氢化为不饱和烃。一种制备选择性氢化催化剂的方法，包括将支持物与含钯化合物接触以形成支持的钯组合物，将支持的钯组合物与有机磷化合物接触以形成催化剂前体，并还原催化剂前体以形成催化剂。一种将高度不饱和烃选择性氢化为富含不饱和烃的组合物的方法，包括将包括钯和有机磷化合物的支持催化剂与含高度不饱和烃的进料接触，在适宜的氢化条件下至少部分氢化高度不饱和烃进料以形成富含不饱和烃的组合物。
• 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0302423A2

  公开（公告）日：1989-02-08

  The present invention relates to novel 1-phenyl-3-(1-­piperazinyl)-1H-indazoles and intermediates and a process for the preparation thereof. The compounds according to the invention exhibit analgesic, anti-convulsive and anti-­depressant activities, and can therefore be used as medicaments.

  本发明涉及新型 1-苯基-3-(1-哌嗪基)-1H-吲唑及其中间体和制备工艺。本发明的化合物具有镇痛、抗惊厥和抗抑郁活性，因此可用作药物。