3-(4-(tert-butyl)phenoxy)pyridine | 2176-43-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(4-(tert-butyl)phenoxy)pyridine
• 英文别名: 3-<4-tert.-Butyl-phenoxy>-pyridin；3-(4-tert-Butyl-phenoxy)-pyridin；3-(4-tert.-Butyl-phenoxy)-pyridin；3-(4-Tert-butylphenoxy)pyridine
• CAS: 2176-43-4
• 化学式: C₁₅H₁₇NO
• 分子量: 227.306
• InChiKey: OUFXIBROOUBIPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-(tert-butyl)phenoxy)pyridine 在 bis-triphenylphosphine-palladium(II) chloride 、 palladium on activated charcoal 、 甲酸铵 、 溶剂黄146 、 间氯过氧苯甲酸 、 silver(l) oxide 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 36.67h， 生成 8-(tert-butyl)benzofuro[3,2-b]pyridine
  参考文献：
  名称：

  Synthesis of Benzofuro[3,2-b]pyridines via Palladium-Catalyzed Dual C–H Activation of 3-Phenoxypyridine 1-Oxides

  摘要：

  An efficient oxidative cyclization to straightforward synthesis of benzofuro[3,2-b]pyridine 1-oxides with high regioselectivity via Pd-catalyzed intramolecular dual C-H activation was developed. The resulting products could be deoxygenated easily to the corresponding benzofuro[3,2-b]pyridines in excellent yields.

  DOI：

  10.1021/ol5033464
• 作为产物：
  描述：

  3-溴吡啶 、 4-叔丁基苯酚 在 copper on carbon 1,10-菲罗啉 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以86%的产率得到3-(4-(tert-butyl)phenoxy)pyridine
  参考文献：
  名称：

  Copper-in-Charcoal (Cu/C) Promoted Diaryl Ether Formation

  摘要：

  Copper impregnated into charcoal efficiently catalyzes cross-couplings between aryl bromides and phenols. The etherifications were conveniently promoted by microwave heating.

  DOI：

  10.1021/ol0700409

文献信息

• 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS AND METHODS OF THEIR USE
  申请人：Devasagayaraj Arokiasamy

  公开号：US20080153852A1

  公开（公告）日：2008-06-26

  Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:

  公式I的化合物已被披露，以及包含它们的组合物和它们的使用方法，用于治疗、预防和/或管理疾病和障碍。
• COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE
  申请人：SHY Therapeutics LLC

  公开号：US20170174699A1

  公开（公告）日：2017-06-22

  Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.

  本文提供了抑制MAPK磷酸化的化合物，因此可用于治疗癌症和炎症性疾病的组合物和方法。
• 4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds and Methods of Their Use
  申请人：Devasagayaraj Arokiasamy

  公开号：US20120041008A1

  公开（公告）日：2012-02-16

  Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:

  公式I的化合物被披露，以及包含它们的组合物和使用它们治疗、预防和/或管理疾病和疾病的方法。
• Methods of using 4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds
  申请人：Devasagayaraj Arokiasamy

  公开号：US20100311764A1

  公开（公告）日：2010-12-09

  Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:

  公式I的化合物被披露，以及包含它们的组合物和使用它们治疗、预防和/或管理疾病和障碍的方法。
• TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF METASTATIC BONE DISEASE
  申请人：Sands Arthur Thomas

  公开号：US20130137635A1

  公开（公告）日：2013-05-30

  This invention relates to tryptophan hydroxylase inhibitors, compositions comprising them, and methods of their use for the treatment, management and/or prevention of metastatic bone disease.

  本发明涉及色氨酸羟化酶抑制剂、包含其的组合物以及它们的使用方法，用于治疗、管理和/或预防转移性骨病。