季戊四醇四(2-乙基乙酸酯) | 7299-99-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 季戊四醇四(2-乙基乙酸酯)
• 中文别名: 季戊四醇四(2-乙基己酸)酯；季戊四醇四辛酸酯；季戊四醇四(乙基己酸)酯
• 英文名称: pentaerythritol tetra(2-ethylhexanoate)
• 英文别名: [3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate
• CAS: 7299-99-2
• 化学式: C₃₇H₆₈O₈
• 分子量: 640.942
• InChiKey: DRRMRHKHTQRWMB-UHFFFAOYSA-N

物化性质

• 沸点：
  415℃[at 101 325 Pa]
• 密度：
  0.96[at 20℃]
• LogP：
  6.7 at 25℃
• 物理描述：
  Liquid
• 保留指数：
  3267
• 稳定性/保质期：
  如果遵照规格使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  11.3
• 重原子数：
  45
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

安全信息

• 储存条件：
  密封储存于阴凉干燥处。

反应信息

• 作为产物：
  描述：

  季戊四醇 、 2-乙基-己酸稀土盐 在 吡啶 、 (chlorosulfinyloxy)-N,N-dimethylmethaniminium chloride 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以98%的产率得到季戊四醇四(2-乙基乙酸酯)
  参考文献：
  名称：

  使用 N,N-二甲基氯-亚硫酸甲亚胺氯化物作为脱水剂从受阻醇中简单方便地一锅法合成脂肪酸酯

  摘要：

  摘要 N,N-二甲基氯亚硫酸盐甲铵氯化物 (SOCl2-DMF) 已被发现是一种在温和条件下从等摩尔量的脂肪酸和受阻醇一锅合成酯的有效试剂。

  DOI：

  10.1081/scc-120006474

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• ANTI-AGING AGENT CONTAINING ARCTIGENIN DERIVATIVE
  申请人：ROHTO Pharmaceutical Co., Ltd.

  公开号：US20150093345A1

  公开（公告）日：2015-04-02

  An arctigenin derivative used for anti-aging treatment, including protection of the skin from the sun and recovery of skin elasticity. A variety of fatty acid ester derivatives, alcohol ether derivatives and alkylated derivatives are used as the arctigenin derivatives. Agents for controlling ET-1 production, elastase inhibitors, and anti-inflammatory agents are prepared. Such arctigenin derivatives are particularly useful as an external agent for the skin, such as an anti-inflammatory external agent, a sunscreen external agent, or an external agent for recovering elasticity.

  一种用于抗衰老治疗的牛蒡素衍生物，包括保护皮肤免受阳光伤害和恢复皮肤弹性。使用各种脂肪酸酯衍生物、醇醚衍生物和烷基衍生物作为牛蒡素衍生物。制备用于控制ET-1产生的药剂、弹性蛋白酶抑制剂和抗炎药剂。这种牛蒡素衍生物特别适用于皮肤外用剂，如抗炎外用剂、防晒外用剂或恢复弹性的外用剂。
• SKIN EXTERNAL PREPARATIONS AND COSMETICS
  申请人：Aoki Hirobumi

  公开号：US20100280111A1

  公开（公告）日：2010-11-04

  An object of the present invention is to provide skin external preparations and cosmetics which contain a branched acyl carnitine and have excellent formulation stability. A skin external preparation of the present invention includes a carnitine derivative represented by the following Formula (1) and/or a carnitine derivative salt represented by the following Formula (2), and an amphoteric surfactant. In Formula (1), R 1 and R 2 are each independently a C1-18 optionally branched, saturated or unsaturated aliphatic hydrocarbon group. In Formula (2), R 1 and R 2 are the same as in Formula (1), X − is a specific anion and Y + is a specific cation.

  本发明的一个目的是提供含有支链酰基肉碱并具有优异配方稳定性的皮肤外用制剂和化妆品。本发明的皮肤外用制剂包括以下式（1）所表示的肉碱衍生物和/或以下式（2）所表示的肉碱衍生物盐，以及一种两性表面活性剂。在式（1）中，R1和R2分别独立地是C1-18的可选支链、饱和或不饱和脂肪烃基。在式（2）中，R1和R2与式（1）中相同，X−是特定的阴离子，Y+是特定的阳离子。
• NOVEL SILICONE COMPOUND AND COSMETIC CONTAINING THEREOF
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20170137574A1

  公开（公告）日：2017-05-18

  The present invention provides a silicone compound shown by the formula (1) and having a weight-average molecular weight in the range of 500 to 200,000, R 1 a R 2 b R 3 c R 4 d SiO (4-a-b-c-d)/2 (1), wherein R 1 represents the same or different organic group, R 2 represents a polyoxyalkylene group shown by —C m H 2m —O—(C 2 H 4 O) g (C 3 H 6 O) h R 6 , R 3 represents a branched type monovalent organosiloxane group shown by the following general formula (4), M o M R p D q D R r T s T R t Q u (4), and R 4 represents a monovalent organosiloxane group shown by the following general formula (5) or the general formula (6), MM R D v-1 (5), M w D v-1 D R v-2 T R v-3 (6). This provides a silicone compound which has excellent emulsification ability and emulsion stability to silicone oil, and can secure high temporal stability.

  本发明提供了一种硅化合物，其化学式为（1），其重均分子量在500至200,000范围内，R1aR2bR3cR4dSiO(4-a-b-c-d)/2(1)，其中R1代表相同或不同的有机基团，R2代表由—CmH2m—O—(C2H4O)g(C3H6O)hR6表示的聚氧烷基团，R3代表由以下一般式（4）表示的分支型一价有机硅氧烷基团，MoMRpDqDRrTsTRtQu(4)，R4代表由以下一般式（5）或一般式（6）表示的一价有机硅氧烷基团，MMRDv-1(5)，MwDv-1DRv-2TRv-3(6)。这提供了一种硅化合物，具有优异的乳化能力和对硅油的乳液稳定性，并且可以确保高时间稳定性。
• COSMETIC
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20200281836A1

  公开（公告）日：2020-09-10

  A cosmetic containing (A) an organo(poly)siloxane shown by the following general formula (1). A cosmetic with a refreshing feeling, smooth spreadability as well as high stability and favorable cosmetic sustainability is provided. [where, in the formula, R 1 represents a group except shown by the formula (2), selected from a C1-C20 alkyl group and a C6-C20 aryl group; n represents an integer of 0 to 3; R 2 and R 3 represent R 1 or the formula (2); and either or both of R 2 and R 3 represent formula (2), (where, in the formula, X represents a C2-C20 alkylene group; and Y represents any one of a hydrogen atom, a C1-C20 alkyl group, a C6-C20 aryl group, a C7-C40 aralkyl group, a C1-C20 alkyloxy group, a C6-C20 aryloxy group, a C7-C40 arylalkyloxy group, and a halogen atom.)]

  一种化妆品，含有以下一般式（1）所示的有机（聚）硅氧烷。提供一种具有清爽感、平滑涂抹性以及高稳定性和良好的化妆品持久性的化妆品。【在公式中，R1代表除公式（2）所示之外的一种基团，选自C1-C20烷基基团和C6-C20芳基基团；n代表0到3之间的整数；R2和R3代表R1或公式（2）；R2和R3中的任一或两者代表公式（2），（在公式中，X代表C2-C20烷基基团；Y代表氢原子、C1-C20烷基基团、C6-C20芳基基团、C7-C40芳基烷基基团、C1-C20烷氧基团、C6-C20芳氧基团、C7-C40芳基烷氧基团和卤素原子中的任意一种。）】