(2,2,5-trimethyl-1,3-dioxan-5-yl)methyl acrylate | 7299-80-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl acrylate
• 英文别名: (2,2,5-Trimethyl-1,3-dioxan-5-yl)methyl prop-2-enoate；(2,2,5-trimethyl-1,3-dioxan-5-yl)methyl prop-2-enoate
• CAS: 7299-80-1
• 化学式: C₁₁H₁₈O₄
• 分子量: 214.262
• InChiKey: GNPBKNRQSJRWRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl acrylate 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 生成 tris(hydroxymethyl)-ethane monoacrylate
  参考文献：
  名称：

  Electrospun Poly(l-lactide-co-acryloyl carbonate) Fiber Scaffolds With a Mechanically Stable Crimp Structure For Ligament Tissue Engineering

  摘要：

  The aim of this study was to prepare a fibrous scaffold that possesses a crimped morphology using a photo-cross-linkable biodegradable copolymer. To obtain the crimped morphology, the polymer was first electrospun onto a rotating wire mandrel to obtain aligned straight fibers. Postprocessing by immersion in aqueous buffer at 37 degrees C generated a crimplike pattern in the fibers. It was reasoned that cross-linking the fibers following formation of the crimped structure would endow the scaffolds with a recoverable crimp pattern and mechanical properties similar to that of the collagen fibers in the anterior cruciate ligament (ACL). To achieve this aim, a trimethylene carbonate based monomer bearing an acrylate pendant group was synthesized and copolymerized with L-lactide. The copolymer was electrospun and photo-cross-linked yielding fibrous scaffolds possessing a substantial increase in tensile modulus and crimp stability compared to the uncross-linked fibrous scaffolds. The crimp-stabilized scaffolds also showed good cytocompatibility toward 3T3 fibroblasts, which attached and grew along the crimped fibers. These findings suggest that these cross-linked fiber scaffolds may be useful for the generation of cultured ligament tissue.

  DOI：

  10.1021/bm401813j
• 作为产物：
  描述：

  1,1,1-三(羟甲基)乙烷 在 对甲苯磺酸 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl acrylate
  参考文献：
  名称：

  Electrospun Poly(l-lactide-co-acryloyl carbonate) Fiber Scaffolds With a Mechanically Stable Crimp Structure For Ligament Tissue Engineering

  摘要：

  The aim of this study was to prepare a fibrous scaffold that possesses a crimped morphology using a photo-cross-linkable biodegradable copolymer. To obtain the crimped morphology, the polymer was first electrospun onto a rotating wire mandrel to obtain aligned straight fibers. Postprocessing by immersion in aqueous buffer at 37 degrees C generated a crimplike pattern in the fibers. It was reasoned that cross-linking the fibers following formation of the crimped structure would endow the scaffolds with a recoverable crimp pattern and mechanical properties similar to that of the collagen fibers in the anterior cruciate ligament (ACL). To achieve this aim, a trimethylene carbonate based monomer bearing an acrylate pendant group was synthesized and copolymerized with L-lactide. The copolymer was electrospun and photo-cross-linked yielding fibrous scaffolds possessing a substantial increase in tensile modulus and crimp stability compared to the uncross-linked fibrous scaffolds. The crimp-stabilized scaffolds also showed good cytocompatibility toward 3T3 fibroblasts, which attached and grew along the crimped fibers. These findings suggest that these cross-linked fiber scaffolds may be useful for the generation of cultured ligament tissue.

  DOI：

  10.1021/bm401813j

文献信息

• 一种含有磷杂菲基团的阻燃二元醇及其制备 方法
  申请人：中国科学技术大学

  公开号：CN104610362B

  公开（公告）日：2017-05-17

  本发明公开了一种含有磷杂菲基团的阻燃二元醇及其制备方法，特征是利用9,10‑二氢‑9‑氧杂‑10‑磷杂菲‑10‑氧化物中的活性P‑H键，通过与含有双键的丙烯酸缩酮酯经加成反应后再水解，制得具有羟基结构对称的含有磷杂菲基团的反应型磷系阻燃二元醇10‑(二羟甲基丙酸乙酯基)‑9,10‑二氢‑9‑氧杂‑10‑磷杂菲‑10‑氧化物。本发明将聚酯、聚碳酸酯、聚醚、聚醚酯或聚氨酯等聚合物合成时常使用的小分子二元醇以化学键入的方式引入磷杂菲基团，使得到的二元醇分子结构中既含有磷杂菲基团，又含有二个结构对称、反应活性相同的羟基，可以部分或全部替代无阻燃特性的小分子二元醇，使制得的聚合物材料具有阻燃特性。
• Sequence-Defined Mikto-Arm Star-Shaped Macromolecules
  作者：Melissa A. Reith、Irene De Franceschi、Matthieu Soete、Nezha Badi、Resat Aksakal、Filip E. Du Prez

  DOI：10.1021/jacs.2c00145

  日期：2022.4.27

  The synthesis of sequence-defined, discrete star-shaped macromolecules is a major challenge due to the lack of straightforward and versatile approaches. Here, a robust strategy is proposed that allows not only the preparation of sequence-defined mikto-arm star-shaped macromolecules but also the synthesis of a series of unprecedented discrete, multifunctional complex architectures with molar masses

  由于缺乏直接和通用的方法，序列定义的离散星形大分子的合成是一项重大挑战。在这里，提出了一种稳健的策略，不仅可以制备序列定义的 mikto-arm 星形大分子，还可以合成一系列摩尔质量高于 11 kDa 的前所未有的离散、多功能复杂结构。所报道的迭代方法利用了现成的结构单元，并产生了具有高纯度和高产率的不对称支化大分子，这展示了单分散的三臂、四臂和五臂星形结构，这些结构均通过以下方式表征LC-MS、MALDI-ToF 和 NMR。这种有效的策略通过同时实现序列定义、分支点的精确插入以及复杂聚合物结构的正交端基功能化，极大地提高了聚合物化学家的合成能力。所提出的方法可以转化为不同的平台，例如肽和类肽，因此在需要单个离散大分子上的多个不同功能部分的生物医学应用中特别有趣。
• Radiation curable compositions for printing on glass
  申请人：AGFA GRAPHICS NV

  公开号：EP3034312A1

  公开（公告）日：2016-06-22

  A radiation curable composition containing a) a free radical polymerizable composition containing at least 95 wt% relative to the free radical polymerizable composition of one or more monofunctional (meth)acrylates, wherein at least 80 wt% of the one or more monofunctional (meth)acrylates consist of monofunctional (meth)acrylates including at least one five or six membered acetal ring in their structure; and b) at least one acetal containing polymer having a plurality of repeating units according to Formula (I): wherein R1 and R2 are independently selected from the group consisting of a hydrogen, an alkyl group, an alkenyl group, an alkynyl group, an aralkyl group, an alkaryl group, an aryl group and a heteoraryl group.

  一种可辐射固化的组合物，其中含有 a) 可自由基聚合的组合物，相对于可自由基聚合的组合物，至少含有 95 wt%的一种或多种单官能团（甲基）丙烯酸酯，其中至少 80 wt%的一种或多种单官能团（甲基）丙烯酸酯由单官能团（甲基）丙烯酸酯组成，在其结构中至少包括一个五或六个成员的缩醛环；以及 b) 至少一种含缩醛的聚合物，其具有符合式（I）的多个重复单元： 其中 R1 和 R2 独立地选自氢、烷基、烯基、炔基、芳烷基、烷芳基、芳基和硬脂酰基组成的组。
• Radiation curable compositions
  申请人：AGFA NV

  公开号：US10752782B2

  公开（公告）日：2020-08-25

  A radiation curable composition including at least one organic silver salt, at least one reducing agent for the organic silver salt, and a polymerizable composition of at least one polymerizable compound, wherein the radiation curable composition is a radiation curable inkjet ink containing at least 50 wt % of a monofunctional polymerizable compound based on the total weight of the polymerizable composition. The radiation curable composition is especially useful for generating black UV light blocking borders in laminated safety glass for automotive applications.

  一种辐射固化组合物，包括至少一种有机银盐、至少一种有机银盐的还原剂和至少一种可聚合化合物的可聚合组合物，其中辐射固化组合物是一种辐射固化喷墨墨水，含有基于可聚合组合物总重量至少 50 wt % 的单官能团可聚合化合物。该辐射固化组合物尤其适用于在汽车用夹层安全玻璃中生成黑色紫外线阻挡边框。
• RADIATION CURABLE COMPOSITIONS
  申请人：AGFA GRAPHICS NV

  公开号：US20170355858A1

  公开（公告）日：2017-12-14

  A radiation curable composition including at least one organic silver salt, at least one reducing agent for the organic silver salt, and a polymerizable composition of at least one polymerizable compound, wherein the radiation curable composition is a radiation curable inkjet ink containing at least 50 wt % of a monofunctional polymerizable compound based on the total weight of the polymerizable composition. The radiation curable composition is especially useful for generating black UV light blocking borders in laminated safety glass for automotive applications.