3-甲基环庚烷-1-酮 | 933-17-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-甲基环庚烷-1-酮
• 英文名称: 3-methylcycloheptanone
• 英文别名: (+/-)-3-Methyl-cycloheptanon；3-methylcycloheptan-1-one
• CAS: 933-17-5
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: GSYFDULLCGVSNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-甲基环庚烷-1-酮 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 trans-1-Methyl-cycloheptanol-(3); trans-3-Methylcycloheptanol
  参考文献：
  名称：

  Proximity Effects. XXVI. Synthesis and Stereochemistry of Bicyclo[5.1.0]octanols

  摘要：

  DOI：

  10.1021/ja00883a042
• 作为产物：
  描述：

  α-乙酰基-γ-丁内酯 在 镍 氢氧化钾 、 硫酸 、 氢气 、 sodium bromide 作用下， 以 甲醇 为溶剂， 生成 3-甲基环庚烷-1-酮
  参考文献：
  名称：

  JAEGER; KEYMER, Archiv der Pharmazie, 1960, vol. 293 /65, p. 896 - 900

  摘要：

  DOI：

文献信息

• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20020045747A1

  公开（公告）日：2002-04-18

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性治疗阿尔茨海默病的方法。
• Ring opening of cyclopropylketones induced by photochemical electron transfer
  作者：Janine Cossy、Nathalie Furet、Samir BouzBouz

  DOI：10.1016/0040-4020(95)00727-p

  日期：1995.10

  Depending on the substitution pattern of cyclopropylketones, the photochemically induced electron transfer of tertiary amines to cyclopropylketones leads either to the formation of 3-substituted cycloalkanones or to ring expanded products.

  根据环丙基酮的取代方式，光化学诱导的叔胺电子转移至环丙基酮会导致3-取代的环烷酮的形成或环扩产物。
• Transition-metal chloride mediated addition reaction of diorganomagnesium to easily enolizable ketones
  作者：Mutsumi Sada、Seijiro Matsubara

  DOI：10.1016/j.tet.2011.02.009

  日期：2011.4

  is difficult to perform with Grignard reagent (RMgX) or with diorganomagnesium (R2Mg), because a deprotonation to form a magnesium enolate occurs predominantly. To avoid the prior enolization, a complex reagent of a transition-metal salt and R2Mg was examined: A combination of R2Mg with iron(II) chloride (FeCl2) or ytterbium(III) chloride (YbCl3) gave a complex reagent that can realize a nucleophilic

  用格氏试剂（RMgX）或用二有机镁（R 2 Mg）很难将烷基化为易于烯化的酮（例如β-四氢萘酮），因为主要发生去质子化反应以形成烯醇镁。为避免先期烯醇化，研究了过渡金属盐和R 2 Mg的复杂试剂：R 2 Mg与氯化铁（II）（FeCl 2）或氯化（（III）（YbCl 3）的混合物可以在烯醇化之前实现与β-四氢萘酮发生亲核反应的复杂试剂。RMGX与这些金属盐的组合是劣于R的组合2的Mg与他们以获得所述亲核试剂复杂。
• PHOTOSENSITIVE COMPOSITION, PATTERN FORMING METHOD USING THE PHOTOSENSITIVE COMPOSITION AND COMPOUND FOR USE IN THE PHOTOSENSITIVE COMPOSITION
  申请人：Wada Kenji

  公开号：US20100233617A1

  公开（公告）日：2010-09-16

  A photosensitive composition includes: (A) a resin containing a repeating unit corresponding to a compound represented by the following formula (I); the resin being capable of producing an acid group upon irradiation with an actinic ray or radiation: Z-A-X—B—R   (I) wherein Z represents a group capable of becoming an acid group resulting from leaving of a cation upon irradiation with an actinic ray or radiation; A represents an alkylene group; X represents a single bond or a heteroatom-containing divalent linking group; B represents a single bond, an oxygen atom or —N(Rx)-; Rx represents a hydrogen atom or a monovalent organic group; R represents a monovalent organic group substituted by Y; when B represents —N(Rx)-, R and Rx may combine with each other to form a ring; and Y represents a polymerizable group.

  一种感光组合物包括：（A）含有与下式（I）所表示的化合物对应的重复单元的树脂；该树脂能够在受到光敏射线或辐射照射后产生酸基团：Z-A-X—B—R   （I）其中Z代表一个能够在受到光敏射线或辐射照射后由阳离子离去而形成酸基团的基团；A代表一个烷基基团；X代表一个单键或含杂原子的二价连接基团；B代表一个单键、一个氧原子或—N（Rx）-；Rx代表一个氢原子或一个一价有机基团；R代表一个通过Y取代的一价有机基团；当B代表—N（Rx）-时，R和Rx可以结合在一起形成一个环；Y代表一个可聚合的基团。
• New Methylene Homologation Method for Cyclic Ketones
  作者：Huaqing Liu、Chunrui Sun、Nam-Kyu Lee、Roger F. Henry、Daesung Lee

  DOI：10.1002/chem.201201346

  日期：2012.9.17

  Teaching new tricks to an old dog: By intercepting adducts between ketones and lithium trimethylsilyldiazomethane, a new Tiffeneau–Demjanov type methylene homologation could be realized in a single‐step operation. Among proton sources and Lewis acids, silica gel was found to be the most effective reagent for the protonation of intermediates and their subsequent ring expansion (see scheme).

  向一只老狗教新的花样：通过截获酮与三甲基硅烷基重氮甲烷锂之间的加合物，可以通过一步操作实现新的Tiffeneau–Demjanov型亚甲基同系物。在质子源和路易斯酸中，发现硅胶是中间体中间体的质子化和随后环扩环的最有效试剂（请参见方案）。