1-Phenyl-1-undecen-3-one | 56843-35-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 1-Phenyl-1-undecen-3-one
• 英文别名: 1-Undecen-3-one, 1-phenyl-；1-phenylundec-1-en-3-one
• CAS: 56843-35-7
• 化学式: C₁₇H₂₄O
• 分子量: 244.377
• InChiKey: IKJLIQNJILFDDF-UHFFFAOYSA-N

物化性质

• 熔点：
  38-39 °C
• 沸点：
  178-180 °C(Press: 0.98 Torr)
• 密度：
  0.941±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Phenyl-1-undecen-3-one 在 溶剂黄146 、 sodium hydroxide 、 锌 作用下， 以 乙醇 、 水 为溶剂， 反应 1.17h， 生成
  参考文献：
  名称：

  伯烯丙基胺的动力学拆分通过丙二腈的钯催化的不对称烯丙基烷基化†

  摘要：

  通过[Pd（烯丙基）Cl] 2 /（S）-BINAP催化和间苯二甲磺酰肼加速丙二腈的不对称烯丙基烷基化反应，涉及一系列对映体，选择性高达491。有氧条件。而且，该反应被证明对于不对称合成具有高对映体纯度的α-支链的烯丙基取代的丙二腈是有用的。

  DOI：

  10.1039/c5ob00671f
• 作为产物：
  描述：

  1-苯基十一碳-1-烯-3-醇 在 9-芴酮 作用下， 以 二甲基亚砜 为溶剂， 以61%的产率得到1-Phenyl-1-undecen-3-one
  参考文献：
  名称：

  空气/氧气作为氧化剂的可见光诱导未活化醇氧化的无金属催化剂

  摘要：

  9-氟丁酮可作为无金属和无添加剂的光催化剂，用于在可见光下选择性氧化伯醇和仲醇。使用这种光催化剂，已使用空气/氧气作为氧化剂将过多的醇（例如脂族，杂芳族，芳族和脂环族化合物）转化为相应的羰基化合物。除这些之外，几种类固醇已被氧化为相应的羰基化合物。还已经进行了详细的机理研究，以确定氧化剂和光催化剂对该氧化的作用。

  DOI：

  10.1021/acscatal.8b01067

文献信息

• Synthesis of α,β-unsaturated ketones from alkynes and aldehydes over Hβ zeolite under solvent-free conditions
  作者：Naresh Mameda、Swamy Peraka、Srujana Kodumuri、Durgaiah Chevella、Rammurthy Banothu、Vasu Amrutham、Narender Nama

  DOI：10.1039/c6ra11593d

  日期：——

  A facile Hβ zeolite-catalyzed strategy has been successfully developed for the synthesis of α,β-unsaturated ketones from alkynes and aldehydes under solvent-free conditions. The reaction proceeds via tandem hydration/condensation of alkynes with aldehydes to afford a range of α,β-unsaturated carbonyls in good to excellent yields.

  已成功开发了一种简便的Hβ沸石催化策略，可在无溶剂条件下从炔烃和醛合成α，β-不饱和酮。该反应通过炔烃与醛的串联水合/缩合而进行，以良好的至优异的产率提供了一系列α，β-不饱和羰基。
• Mid-term Results of the Ross Procedure
  作者：Domenico Paparella、Tirone E. David、Susan Armstrong、Joan Ivanov

  DOI：10.1111/j.1540-8191.2001.tb00533.x

  日期：2001.7

  Although the Ross procedure has been performed for over three decades, its role in the management of patients with aortic valve disease is not well established. This study reviews our experience with this operation. From 1990 to 1999, 155 patients underwent the Ross procedure. The mean age of 106 men and 49 women was 35 years. Most patients (85%) had congenital aortic valve disease. The pulmonary autograft was implanted in the subcoronary position in 2 patients, as an aortic root inclusion in 78, and aortic root replacement in 75. The follow-up extended from 9 to 114 months, mean of 45 +/- 28 months, and it was complete. All patients have had Doppler echocardiographic studies. There was only one operative and one late death. The survival was 98% at 7 years. The freedom from 3+ or 4+ aortic insufficiency was 86% at 7 years and the freedom from reoperation on the pulmonary autograft was 95% at 7 years. Dilation of the aortic annulus and/or sinotubular junction was the most common cause of aortic insufficiency. One patient required three reoperations on the biological pulmonary valve. Most patients (96%) have no cardiac symptoms. The Ross procedure has provided excellent functional results in most patients, but progressive aortic insufficiency due to dilation of the aortic annulus and/or sinotubular junction is a potential problem in a number of patients.
• Organocatalytic Asymmetric Michael-Type/Wittig Reaction of Phosphorus Ylides: Synthesis of Chiral α-Methylene-δ-Ketoesters
  作者：Aijun Lin、Junying Wang、Haibin Mao、Huiming Ge、Renxiang Tan、Chengjian Zhu、Yixiang Cheng

  DOI：10.1021/ol201483s

  日期：2011.8.19

  An asymmetric Michael-type reaction of phosphorus ylides and alpha,beta-unsaturated ketones under the catalysis of a chiral ion pair catalyst has been described. The ion pair catalyst containing a chiral counteranion was prepared by simply mixing 9-amino-(9-deoxy)-epl-quinine with L-N-Boc-proline. The optically active alpha-methylene-delta-ketoesters could be obtained with good to excellent enantloselectivities (up to 95% ee) under mild reaction conditions.
• Tolstikov, G. A.; Valitov, F. Kh.; Kuchin, A. V., Journal of general chemistry of the USSR, 1981, vol. 51, # 7, p. 1359 - 1361
  作者：Tolstikov, G. A.、Valitov, F. Kh.、Kuchin, A. V.

  DOI：——

  日期：——
• Ohta, Hiromichi; Fujiwara, Hidenori; Tsuchihashi, Gen-ichi, Agricultural and Biological Chemistry, 1984, vol. 48, # 6, p. 1509 - 1516
  作者：Ohta, Hiromichi、Fujiwara, Hidenori、Tsuchihashi, Gen-ichi

  DOI：——

  日期：——