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1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-L-arabinofuranosyl>uracil | 160946-67-8

中文名称
——
中文别名
——
英文名称
1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-L-arabinofuranosyl>uracil
英文别名
1-[(6aS,8S,9R,9aR)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione
1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-L-arabinofuranosyl>uracil化学式
CAS
160946-67-8
化学式
C21H38N2O7Si2
mdl
——
分子量
486.713
InChiKey
KKLQDUCRZCCKHG-RNQOJCNYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.75
  • 重原子数:
    32.0
  • 可旋转键数:
    5.0
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.81
  • 拓扑面积:
    112.01
  • 氢给体数:
    2.0
  • 氢受体数:
    8.0

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-L-arabinofuranosyl>uracilchromium(VI) oxide四丁基氟化铵乙酸酐 、 sodium hydride 作用下, 以 四氢呋喃吡啶二甲基亚砜 为溶剂, 反应 4.5h, 生成 2'-deoxy-2'-methylene-β-L-uridine
    参考文献:
    名称:
    Synthesis of 1-β-L-Arabinofuranosylcytosine (β-L-Ara-C) and 2′-Deoxy-2′-methylene-β-L-cytidine (β-L-DMDC) as Potential Antineoplastic Agents
    摘要:
    1-beta-L-Arabinofuranosylcytosine (beta-L-Ara-C, 7) and 2'-deoxy-2'-methylene-beta-L-cytidine (beta-L-DMDC, 14) have been synthesized via a multi-step synthesis from L-arabinose. These compounds were tested in vitro against L1210, P388, Sarcoma 180, and CEM cells, and found not to be active at a concentration up to 100 mu M. beta-L-Ara-C and beta-L-DMDC were also tested against HSV-1 and HSV-2 and yielded ID50 values of >100 mu M.
    DOI:
    10.1080/15257779408010669
  • 作为产物:
    参考文献:
    名称:
    Synthesis of 1-β-L-Arabinofuranosylcytosine (β-L-Ara-C) and 2′-Deoxy-2′-methylene-β-L-cytidine (β-L-DMDC) as Potential Antineoplastic Agents
    摘要:
    1-beta-L-Arabinofuranosylcytosine (beta-L-Ara-C, 7) and 2'-deoxy-2'-methylene-beta-L-cytidine (beta-L-DMDC, 14) have been synthesized via a multi-step synthesis from L-arabinose. These compounds were tested in vitro against L1210, P388, Sarcoma 180, and CEM cells, and found not to be active at a concentration up to 100 mu M. beta-L-Ara-C and beta-L-DMDC were also tested against HSV-1 and HSV-2 and yielded ID50 values of >100 mu M.
    DOI:
    10.1080/15257779408010669
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