泛醌 | 1339-63-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 泛醌
• 英文名称: 2-geranyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone
• 英文别名: 2-Geranyl-5,6-dimethoxy-3-methyl-[1,4]benzochinon；Ubiquinones；2-(3,7-dimethylocta-2,6-dienyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
• CAS: 1339-63-5
• 化学式: C₁₉H₂₆O₄
• 分子量: 318.413
• InChiKey: SQQWBSBBCSFQGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3-二甲氧基-5-甲基-1,4-苯醌 在 Lindlar's catalyst 氢气 作用下， 生成 泛醌
  参考文献：
  名称：

  Obol'nikova,E.A. et al., Journal of general chemistry of the USSR, 1968, vol. 38, p. 453 - 456

  摘要：

  DOI：

文献信息

• Radical-Mediated Synthesis of Substituted Quinones with Organotellurium Compounds
  作者：Shigeru Yamago、Masahiro Hashidume、Jun-ichi Yoshida

  DOI：10.1246/cl.2000.1234

  日期：2000.11

  Carbon-centered radicals generated from the corresponding organotellurium compounds react with a variety of quinones under photo–thermal conditions to give the monoaddition product in good to excellent yield. The reaction can be used for the synthesis of polyprenyl quinoid natural products.

  由相应的有机碲化合物产生的以碳为中心的自由基在光热条件下与各种醌反应，以良好或优异的收率得到单加成产物。该反应可用于合成聚异戊二烯醌天然产物。
• A new synthetic route to substituted quinones by radical-mediated coupling of organotellurium compounds with quinones
  作者：Shigeru Yamago、Masahiro Hashidume、Jun-ichi Yoshida

  DOI：10.1016/s0040-4020(02)00784-6

  日期：2002.8

  Carbon-centered radicals generated from the corresponding organotellurium compounds react with a variety of quinones under photo-thermal conditions to give the monoaddition product in moderate to excellent yield. The reaction can be used for the synthesis of polyprenyl quinoid natural products and C-glycosides.

  由相应的有机碲化合物产生的以碳为中心的自由基在光热条件下与各种醌反应，以中等至极好的收率得到单加成产物。该反应可用于合成聚异戊二烯基醌类天然产物和C-糖苷。
• Compositions and methods for antibody production
  申请人：ImmunoGen, Inc.

  公开号：US10913795B2

  公开（公告）日：2021-02-09

  Compositions and methods for minimizing antibody disulfide bond reduction are described. In one aspect, a composition is provided for culturing mammalian host cells to express an antibody including an anti-reduction agent that minimizes reduction of a disulfide bond in the antibody or fragment thereof. In some other aspects, methods for minimizing disulfide bond reduction; increasing production of an antibody or fragment thereof with intact native disulfide bonds; increasing a ratio of non-reduced to reduced antibody or fragment thereof; producing a therapeutic antibody or fragment thereof by adding a sufficient amount of an anti-reduction agent to a cell culture media, pre-harvest cell culture fluid, or harvest cell culture fluid are described. In another aspect, minimizing disulfide bond reduction in an antibody or fragment thereof culturing the host cell in a concentration of at least about 20% O2 is described.

  本文描述了使抗体二硫键还原最小化的组合物和方法。在一个方面，提供了一种用于培养哺乳动物宿主细胞以表达抗体的组合物，该组合物包括一种抗还原剂，可最大程度地减少抗体或其片段中二硫键的还原。在其他一些方面，描述了使二硫键还原最小化的方法；提高具有完整原生二硫键的抗体或其片段的产量；提高非还原抗体或其片段与还原抗体或其片段的比例；通过向细胞培养基、收获前细胞培养液或收获细胞培养液中添加足量的抗还原剂来生产治疗性抗体或其片段。在另一个方面，描述了在至少约 20% 的氧气浓度下培养宿主细胞可最大程度地减少抗体或其片段中的二硫键还原。
• COENZYME Q. II. SYNTHESIS OF 6-FARNESYL- AND 6-PHYTYL-DERIVATIVES OF 2,3-DIMETHOXY-5-METHYLBENZOQUINONE AND RELATED ANALOGS
  作者：Clifford H. Shunk、Bruce O. Linn、Emily L. Wong、Paul E. Wittreich、Franklin M. Robinson、Karl Folkers

  DOI：10.1021/ja01550a097

  日期：1958.9
• PRO-OXIDANT ANTI-CANCER COMPOUNDS
  申请人：Ralph, Stephen John

  公开号：EP2063884B1

  公开（公告）日：2014-08-13