t-Butyl-retinoic acid | 140939-20-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: t-Butyl-retinoic acid
• 英文别名: all-trans retinoic acid tert-butyl ester；retinyl tert-butyl ether；tert-butyl (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate
• CAS: 140939-20-4
• 化学式: C₂₄H₃₆O₂
• 分子量: 356.549
• InChiKey: SCFZQHNTLYUQFO-JPYACPPYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  维A酸 、 叔丁醇 在 吡啶 、 草酰氯 作用下， 以 乙醚 为溶剂， 反应 0.5h， 以82.6%的产率得到t-Butyl-retinoic acid
  参考文献：
  名称：

  [EN] METHOD OF REDUCING TOXICITY OF RETINOIDS
  [FR] PROCEDE DE REDUCTION DE LA TOXICITE DE RETINOIDES

  摘要：

  公开号：

  WO2004065358A3

文献信息

• Novel Polyunsaturated Compounds, Method for Preparing Same and Compositions Containing the Same
  申请人：Bordat Pascal

  公开号：US20100168045A1

  公开（公告）日：2010-07-01

  The invention concerns novel polyunsaturated compounds of formula (I) wherein: R 1 represents a R′ 1 , -A-R′ 1 group, R′ 1 being selected from —COOH, —COOR 3 , —CONH 2 , —CONHR 3 , —CONR 3 , R 4 , —CHO, —CH 2 OH, —CH 2 OR 5 , and A represents a C 2 -C 16 alkylene, alkenylene or alkynylene; R 2 represents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a —OC—(CH 2 )n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a —R′ 2 —O—R 6 group, wherein R′ 2 is an optionally substituted arylene group or an optionally substituted heteroarylene group, and R 6 represents a hydrogen atom, a straight or branched optionally substituted C 1 -C 16 alkyl, a straight or branched optionally substituted C 2 -C 16 alkenyl, or a straight or branched C 2 -C 16 alkynyl group, an optionally substituted tocopheryl radical or the like, an amino acid residue, or a sugar residue. The invention also concerns the compositions, in particular cosmetic and/or dermatological compositions containing at least one compound of formula (I) as well as their use as whitening and/or depigmenting agent, and the cosmetic method using said compositions.

  本发明涉及一种新型多不饱和化合物，其化学式为(I)，其中：R1代表R′1、-A-R′1基团，R′1从-COOH、-COOR3、-CONH2、-CONHR3、-CONR3、R4、-CHO、-CH2OH、-CH2OR5中选择，A代表C2-C16烷基、烯基或炔基；R2代表：可选取取代芳基或可选取取代杂环芳基；糖残基或脂肪酸残基，可选取支链和/或取代基，优选在链末端特别是由羟基、乙酰氧基基团或可选保护的氨基基团取代的脂肪酸残基；-OC-(CH2)nCO-生育酚（α、β、γ或δ）基团，其中2≤n≤10；-R′2-O-R6基团，其中R′2为可选取取代芳烃基团或可选取取代杂环芳烃基团，R6代表氢原子、直链或支链的可选取代C1-C16烷基、直链或支链的可选取代C2-C16烯基或直链或支链的C2-C16炔基，可选取取代的生育酚基团或类似物、氨基酸残基或糖残基。本发明还涉及包含至少一种化合物(I)的组合物，特别是化妆品和/或皮肤科学组合物，以及它们作为美白和/或脱色剂的用途，以及使用所述组合物的美容方法。
• THE USE OF RETINOIDS AND MINOXIDIL (2,4-DIAMINO-6-PIPERIDINO-PYRIMIDINE-3-OXIDE) TO INCREASE THE RATE OF GROWTH OF HUMAN SCALP HAIR AND TO TREAT CERTAIN TYPES OF ALOPECIAS
  申请人：BAZZANO, Gail S

  公开号：EP0093770B1

  公开（公告）日：1991-06-19
• NOUVEAUX COMPOSÉS POLYINSATURÉS, LEUR PROCÉDÉ DE PRÉPARATION ET LES COMPOSITIONS LES CONTENANT
  申请人：Pierre Fabre Dermo-Cosmétique

  公开号：EP1968993B1

  公开（公告）日：2012-01-11
• Modified Retinoid Compounds and Their Uses
  申请人：DeLuca Hector F.

  公开号：US20080194534A1

  公开（公告）日：2008-08-14

  A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group and the resulting modified retinoids are described. The method comprises the step of esterifying the carboxyl group of the retinoid with a highly sterically hindered compound, which is preferably a secondary or tertiary alcohol. The resulting retinoid esters are rendered much less toxic than the starting or parent retinoid. This process provides a retinoid ester analog of reduced toxicity so that it may be administered orally with minimal side effects and with a much greater therapeutic window. The modified retinoid compounds are useful in the treatment and prophylaxis of all diseases and disorders where retinoid compounds have been shown effective.
• Use of Polyunsaturated Compounds as Whitening Agents
  申请人：Bordat Pascal

  公开号：US20090304614A1

  公开（公告）日：2009-12-10

  The invention concerns the cosmetic or dermatological use of at least one compound of formula (I), wherein: R 1 , R 2 , R 3 , R 4 , R 5 and G are such as defined in the description as whitening and/or depigmenting agents for the skin and/or hairs and/or the hair. The invention also concerns a cosmetic method for whitening and/or lightening the skin and/or hairs and/or the hair comprising applying a composition of the invention.