3,3-Dimethyl-bicyclo<2.2.1>hept-2-yl-acetaldehyd

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3,3-Dimethyl-bicyclo<2.2.1>hept-2-yl-acetaldehyd
• 英文别名: 2-[(1R,2R,4S)-3,3-dimethyl-2-bicyclo[2.2.1]heptanyl]acetaldehyde
• 化学式: C₁₁H₁₈O
• 分子量: 166.263
• InChiKey: ZIIKSEQIKREAGR-KXUCPTDWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  溴乙烷 、 3,3-Dimethyl-bicyclo<2.2.1>hept-2-yl-acetaldehyd 在 magnesium 作用下， 生成 1-(3,3-Dimethyl-bicyclo<2.2.1>hept-2-yl)-butan-2-ol
  参考文献：
  名称：

  Zur Synthese vonendo-konfigurierten Isocamphanderivaten

  摘要：

  DOI：

  10.1007/bf00809157
• 作为产物：
  描述：

  Camphenilanol 在 吡啶 、 二异丁基氢化铝 作用下， 以 正己烷 、 二甲基亚砜 为溶剂， 反应 16.25h， 生成 3,3-Dimethyl-bicyclo<2.2.1>hept-2-yl-acetaldehyd
  参考文献：
  名称：

  Zur Synthese vonendo-konfigurierten Isocamphanderivaten

  摘要：

  DOI：

  10.1007/bf00809157

文献信息

• Rhodium-catalyzed hydroformylation of olefins: Effect of [bis(2,4-di-tert-butyl) pentaerythritol] diphosphite (alkanox P-24) on the regioselectivity of the reaction
  作者：Jimoh Tijani、Bassam El Ali

  DOI：10.1016/j.jorganchem.2007.04.022

  日期：2007.7

  pentaerythritol] diphosphite (I) as a ligand represents an active catalyst system for highly regioselective hydroformylation of various alkenes. The commercially available bis(2,4-di-tert-butyl)pentaerythritol diphosphite (alkanox P-24) (I), which has been used so far as an antioxidant in the stabilization of polymers, was used as a diphosphite ligand for the selective hydroformylation reaction of olefins

  铑（I）与相关联的[双（2,4-二-叔丁基）季戊四醇]亚磷酸酯（我）作为配位体表示关于各种烯烃的高度选择性加氢甲酰基化的活性催化剂体系。迄今为止，作为抗氧化剂用于稳定聚合物的市售双（2,4-二叔丁基）季戊四醇二亚磷酸酯（alkanox P-24）（I）被用作二亚磷酸酯配体。烯烃的选择性加氢甲酰化反应。在烯烃的加氢甲酰化中，获得了对线性醛的优异选择性和出色的转化率。将加氢甲酰化反应应用于包括内部烯烃在内的各种烯烃底物。
• Highly Efficient Rhodium-Phosphite Catalyzed Hydroformylation of Camphene and other Terpenes
  作者：Nitin S. Pagar、Raj M. Deshpande

  DOI：10.14233/ajchem.2019.21656

  日期：——

  The hydroformylation of terpenes has been studied with homogeneous Rh, Co and Pt complexes. The rhodium complex, Rh(CO)2(acac) modified with triphenyl phosphite ligand has been found to be the best catalyst system for hydroformylation of camphene and other terpenes. The role of ligands, solvents, Rh:P ratio and reaction conditions on the activity and selectivity towards camphene hydroformylation have been investigated

  异戊二烯的加氢甲酰化反应已使用均相铑、钴和铂配合物进行了研究。发现经过三苯基膦配体修饰的铑配合物Rh(CO)2(acac)是樟脑和其他萜类化合物加氢甲酰化反应的最佳催化体系。研究了配体、溶剂、铑与磷的比率以及反应条件对樟脑加氢甲酰化反应活性和选择性的影响。
• Kinetics of hydroformylation of camphene using rhodium‐phosphite catalyst
  作者：Nitin S. Pagar、Kalpendra B. Rajurkar、Raj M. Deshpande

  DOI：10.1002/kin.21364

  日期：2020.7

  hydroformylation of camphene was investigated in the presence of [Rh(CO)2(acac)]/P(OPh)3 catalyst in a temperature range of 363–383 K. The influence of parameters such as stirring speed, camphene, catalyst, ligand concentrations, and partial pressures of H2 and CO on the activity and selectivity of the catalyst has been studied. The rate showed a first‐order dependence with respect to catalyst and camphene concentrations

  在[Rh（CO）2（acac）] / P（OPh）3催化剂存在下，在363-383 K的温度范围内研究了camp烯的加氢甲酰化动力学。搅拌速度，camp烯，催化剂等参数的影响，配体浓度，H 2和CO的分压对催化剂活性和选择性的研究。该速率显示出对催化剂和concentrations烯浓度的一级依赖性。氢分压的影响表现出分数阶依赖性。速率与过量配体的关系图，即（P（OPh）3）浓度和速率对通过最大压力的CO分压的影响，并显示出典型的底物/配体抑制动力学。已经提出了经验速率方程，并发现它与观察到的速率数据非常吻合。还评估了动力学参数和活化能。
• Cationic rhodium(I) complexes containing 4,4′-disubstituted 2,2′-bipyridines: A systematic variation on electron density over the metal centre
  作者：Paulo E.A. Ribeiro、Claudio L. Donnici、Eduardo N. dos Santos

  DOI：10.1016/j.jorganchem.2005.12.049

  日期：2006.4

  A series of [Rh(COD)(X-2-bipy)]BF4 complexes (COD = 1,5-cyclooctadiene; X-2-bipy = 4,4'-disubstituted 2,2'-bipyridines; X = OCH3, CH3, H, Cl or NO2) has been prepared from [Rh(COD)Cl](2). The complexes for X = OCH3, Cl and NO2 have not been described previously in the literature. All complexes have been characterised by elemental analysis, IR, H-1 NMR and UV-Vis spectrometry. This series of complexes presents a wide variation on electron density over the metal centre with virtually no variation on its steric environment which discloses interesting possibilities for catalytic and electro-catalytic studies. A preliminary evaluation of these complexes on the hydroformylation of camphene and beta-pinene showed that under the rather drastic conditions employed the complexes acted as a precursor for (Rh(CO)(3)H], which accounts for most of the catalytic activity. (c) 2006 Elsevier B.V. All rights reserved.