2-Acetamido-2,6-didesoxy-6-chloro-d-glucopyranose | 41897-77-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Acetamido-2,6-didesoxy-6-chloro-d-glucopyranose
• 英文别名: N-[(3R,4R,5S,6S)-6-(chloromethyl)-2,4,5-trihydroxyoxan-3-yl]acetamide
• CAS: 41897-77-2
• 化学式: C₈H₁₄ClNO₅
• 分子量: 239.656
• InChiKey: VFQGTCFJJNPVNL-RTRLPJTCSA-N

物化性质

• 沸点：
  564.8±50.0 °C(Predicted)
• 密度：
  1.48±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  99
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Acetamido-2,6-didesoxy-6-chloro-d-glucopyranose 在 吡啶 、 4-二甲氨基吡啶 、 偶氮二异丁腈 、 三氟甲磺酸三甲基硅酯 、 4 A molecular sieve 、 camphor-10-sulfonic acid 、 三正丁基氢锡 、 溶剂黄146 、 三乙胺 、 三丁基氧化锡 、 锌 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 79.5h， 生成 allyl 2-O-(2-acetamido-3,4-di-O-acetyl-2,6-dideoxy-β-D-glucopyranosyl)-3-O-carbamoyl-4-O-(2,2,2-trichloroethoxy)carbonyl-α-D-galactopyranosiduronamide
  参考文献：
  名称：

  The first moenomycin antibiotic without the methyl-branched uronic acid constituent.- Unexpected structure activity relations

  摘要：

  Isolation and structure elucidation of a new moenomycin antibiotic (C1, 1e) that lacks the branching methyl group in the 4-position of unit F are reported. The smallest antibiotically active degradation product of le is the trisaccharide derivative 3. This observation is in contrast to structure activity relations in the moenomycin A series where it was found that disaccharide 4a is fully active.

  DOI：

  10.1016/s0040-4020(01)87242-2
• 作为产物：
  描述：

  D-GlcNAc 在 吡啶 、 四氯化碳 、 三苯基膦 作用下， 以49%的产率得到2-Acetamido-2,6-didesoxy-6-chloro-d-glucopyranose
  参考文献：
  名称：

  卤化选择性的c-6 de 2-氨基-2-脱氧-d-甘露聚糖

  摘要：

  通过用三苯基膦-碳四卤化物-吡啶处理，可以在C-6上选择性地卤化N-保护的2-氨基-2-脱氧-D-Glycopyranoses。

  DOI：

  10.1016/0040-4039(91)80604-5

文献信息

• METHOD FOR OPTIMIZING POST-TRANSLATIONAL MODIFICATIONS ON RECOMBINANT PROTEINS
  申请人：Leszcyniecka, Magdalena

  公开号：EP3094639A1

  公开（公告）日：2016-11-23
• [EN] METHOD FOR OPTIMIZING POST-TRANSLATIONAL MODIFICATIONS ON RECOMBINANT PROTEINS<br/>[FR] PROCÉDÉ D'OPTIMISATION DES MODIFICATIONS POST-TRADUCTIONNELLES EFFECTUÉES SUR DES PROTÉINES RECOMBINÉES
  申请人：LESZCYNIECKA MAGDALENA

  公开号：WO2015106276A1

  公开（公告）日：2015-07-16

  A method for optimizing post-translational modifications of recombinant proteins expressed in living cells is described. More particularly, a method for modulation of host proteins in living cells that control PTMs on recombinant proteins is described that has particularly useful applications in developing manufacturing process changes or in biosimilar development. The goal of this modulation is to produce a recipe for production of a recombinant protein in the new process or in the biosimilar that will produce a targeted PTM profile in the resulting protein product. In the method one or more modulators are selected, as from a modulator library, which affect the activity of host proteins. These modulators are added to media during production such that the resulting product matches the PTMs of the reference product. The ideal set of modulators and their concentrations are identified through a unique iterative process and the combined modulators and their concentrations constitute a recipe for growth media for the production of said recombinant protein. The methodology to obtain such a recipe described herein may then be used in many applications, such as optimizing new batches of recombinant protein drugs, developing biosimilar or bio-better drugs.