(3R,4R,5S,6R)-2-(3-(2-(4-ethoxyphenyl)propan-2-yl)-2-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | 1333113-35-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,4R,5S,6R)-2-(3-(2-(4-ethoxyphenyl)propan-2-yl)-2-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
• CAS: 1333113-35-1
• 化学式: C₂₄H₃₂O₆
• 分子量: 416.514
• InChiKey: WNWGMRLOQMQUJG-HZQGQDIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  30.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  99.38
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (3R,4R,5S,6R)-2-(3-(2-(4-ethoxyphenyl)propan-2-yl)-2-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 在 sodium methylate 、 sodium acetate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 生成 (2S,3R,4R,5S,6R)-2-(3-(2-(4-ethoxyphenyl)propan-2-yl)-2-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  参考文献：
  名称：

  Design, synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors

  摘要：

  A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors, with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key step. The in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test (OGTT), and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin. (C) 2011 Gui Long Zhao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2011.05.022
• 作为产物：
  描述：

  葡萄糖酸内酯 在 N-甲基吗啉 、 三乙基硅烷 、 正丁基锂 、 甲烷磺酸 、 三氟化硼乙醚 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (3R,4R,5S,6R)-2-(3-(2-(4-ethoxyphenyl)propan-2-yl)-2-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  参考文献：
  名称：

  Design, synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors

  摘要：

  A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors, with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key step. The in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test (OGTT), and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin. (C) 2011 Gui Long Zhao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2011.05.022