malonic acid monomenthyl ester | 854823-17-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: malonic acid monomenthyl ester
• 英文别名: Malonsaeure-monomenthylester；Malonsaeuremonomenthylester；3-(5-Methyl-2-propan-2-ylcyclohexyl)oxy-3-oxopropanoic acid
• CAS: 854823-17-9
• 化学式: C₁₃H₂₂O₄
• 分子量: 242.315
• InChiKey: FQELCANCOKLAGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  dimenthyl malonate 在 乙醇 、 sodium ethanolate 作用下， 生成 malonic acid monomenthyl ester
  参考文献：
  名称：

  Rule; Hay; Paul, Journal of the Chemical Society, 1928, p. 1355

  摘要：

  DOI：

文献信息

• Photostable sunscreen compositions comprising cinnamate ester UV-B filters and s-triazine compounds
  申请人：Richard Herve

  公开号：US20080008669A1

  公开（公告）日：2008-01-10

  Photostable sunscreen compositions containing at least one cinnamic acid ester UV-B filter and at least one particular s-triazine compound have improved effectiveness with respect to UV-B radiation.

  含有至少一种肉桂酸酯UV-B过滤剂和至少一种特定的s-三嗪化合物的光稳定防晒霜组合物在UV-B辐射方面具有改善的效果。
• Composition for improving cooling sensation effects
  申请人：Takasago International Corporation

  公开号：EP1197205A2

  公开（公告）日：2002-04-17

  Disclosed is a composition for improving cooling sensation effect that contains a cooling sensation substance and cationic surfactant. A composition additionally containing vanilylalkyl ether (in which the alkyl group has 1 to 6 carbon atoms) is also effective as a composition for improving cooling sensation effect. The present composition for improving cooling sensation effect improves cooling sensation effect while also sustaining that effect. In particular, provided is a composition for improving cooling sensation effect that is able to impart a cooling sensation effect and sustain that effect when used after washing the hair using a shampoo containing no cooling sensation substance or a shampoo containing only a small amount of cooling sensation substance.

  本发明公开了一种用于改善冷感效果的组合物，该组合物含有冷感物质和阳离子表面活性剂。此外，含有香兰素烷基醚（其中烷基具有 1 至 6 个碳原子）的组合物也可有效改善凉感效果。本发明用于改善凉感效果的组合物在改善凉感效果的同时还能保持该效果。特别是，本发明提供了一种用于改善凉感效果的组合物，当使用不含凉感物质的洗发水或仅含少量凉感物质的洗发水洗发后，使用该组合物能够产生凉感效果并维持该效果。
• REFRIGERANT COMPOSITIONS, REFRIGERANT AUXILIARY COMPOSITIONS AND USES THEREOF
  申请人：Takasago International Corporation

  公开号：EP1496095A1

  公开（公告）日：2005-01-12

  The cool feeling composition of the present invention obtained by combining a cool feeling substance containing at least one compound selected from 1-menthol, isopulegol, 3-(1-menthoxy)propane-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propane-1,2-diol, N-ethyl-1-menthylcarboxamide, p-menthane-3,8-diol, 1-menthyl lactate, and 2-isopropyl-N,2,3-trimethylbutanamide with a salicylic acid ester represented by the following general formula (I), such as 2-hydroxyethyl salicylate, improves strength and persistency of cool feeling effect, particularly, those containing 1-menthol as the cool feeling substance can alleviate the irritant fragrance note resulting from 1-menthol. Mixing of the cool feeling composition or fragrance composition containing the same with products such as foods and drinks, cosmetics, toiletry products, bath agents, and pharmaceuticals can afford products wherein the above features of the cool feeling composition of the invention are effectively exerted. wherein R represents a hydrocarbon group having 1 to 18 carbon atoms which may has a substituent.

  本发明的清凉感组合物通过将含有至少一种选自 1-薄荷醇、异薄荷醇、3-(1-薄荷氧基)丙烷-1,2-二醇、2-(1-薄荷氧基)乙烷-1-醇、3-(1-薄荷氧基)丙烷-1-醇、2-甲基-3-(1-薄荷氧基)丙烷-1,2-二醇、N-乙基-1-薄荷甲酰胺、对薄荷-3,8-二醇、1-薄荷乳酸酯和 2-异丙基-N,2,3-三甲基丁酰胺的化合物的清凉感物质与下述通式(I)代表的水杨酸酯（如水杨酸 2-羟乙基酯）结合而获得，可改善清凉感、和 2-异丙基-N,2,3-三甲基丁酰胺与以下通式（I）代表的水杨酸酯（如水杨酸 2-羟乙基酯）混合，可提高清凉感的强度和持久性，特别是含有 1-薄荷醇作为清凉感物质的清凉感组合物，可减轻 1-薄荷醇产生的刺激性香味。将清凉感组合物或含有清凉感组合物的香料组合物与食品和饮料、化妆品、盥洗用品、沐浴剂和药品等产品混合，可以得到有效发挥本发明清凉感组合物上述特点的产品。 其中 R 代表具有 1 至 18 个碳原子的烃基，该烃基可能具有取代基。
• Hair growth composition
  申请人：RIKEN

  公开号：US10543227B2

  公开（公告）日：2020-01-28

  The invention of this application relates to a composition for growing hairs comprising, as an active ingredient, thiosulfuric acid or a salt thereof that has hair growing effects and has no side effects.

  本申请的发明涉及一种生发组合物，其活性成分包括硫代硫酸或其盐类，具有生发效果且无副作用。
• Refrigerant composition, refrigerant auxiliary compositions and uses thereof
  申请人：Ishida Kenya

  公开号：US20050129721A1

  公开（公告）日：2005-06-16

  The cool feeling composition of the present invention obtained by combining a cool feeling substance containing at least one compound selected from 1-menthol, isopulegol, 3-(1-menthoxy)propane-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propane-1,2-diol, N-ethyl-l-menthylcarboxamide, p-menthane-3,8-diol, 1-menthyl lactate, and 2-isopropyl-N, 2,3-trimethylbutanamide with a salicylic acid ester represented by the following general formula (I), such as 2-hydroxyethyl salicylate, improves strength and persistency of cool feeling effect, particularly, those containing 1-menthol as the cool feeling substance can alleviate the irritant fragrance note resulting from 1-menthol. Mixing of the cool feeling composition or fragrance composition containing the same with products such as foods and drinks, cosmetics, toiletry products, bath agents, and pharmaceuticals can afford products wherein the above features of the cool feeling composition of the invention are effectively exerted. wherein R represents a hydrocarbon group having 1 to 18 carbon atoms which may has a substituent.

  本发明的清凉感组合物通过将含有至少一种选自 1-薄荷醇、异薄荷醇、3-(1-薄荷氧基)丙烷-1,2-二醇、2-(1-薄荷氧基)乙醇、3-(1-薄荷氧基)丙烷-1-醇、2-甲基-3-(1-薄荷氧基)丙烷-1,2-二醇、N-乙基-l-薄荷甲酰胺、对薄荷-3,8-二醇、1-薄荷乳酸酯和 2-异丙基-N,2,3-三甲基丁酰胺的化合物的清凉感物质与下述通式(I)代表的水杨酸酯(如水杨酸 2-羟乙基酯)相结合而获得，可改善清凉感、和 2-异丙基-N,2,3-三甲基丁酰胺与下一通式（I）所代表的水杨酸酯（如水杨酸 2-羟乙基酯）混合，可提高清凉感的强度和持久性，尤其是含有 1-薄荷醇作为清凉感物质的清凉感组合物，可减轻 1-薄荷醇所产生的刺激性香味。将清凉感组合物或含有清凉感组合物的香料组合物与食品和饮料、化妆品、盥洗用品、沐浴剂和药品等产品混合，可以得到有效发挥本发明清凉感组合物上述特点的产品。 其中 R 代表具有 1 至 18 个碳原子的烃基，该烃基可能具有取代基。