1-[7-chloro-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone | 437384-18-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[7-chloro-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone
• 英文别名: 1-[7-(Chloro)-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone
• CAS: 437384-18-4
• 化学式: C₁₆H₁₃ClN₂O₂
• 分子量: 300.744
• InChiKey: KZTNICPUZFGBMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[7-chloro-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone 在 palladium diacetate 三溴化硼 、 potassium carbonate 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 138.0h， 生成 2-[4-(allyloxy)phenyl]-N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]pyrazolo[1,5-a]pyridin-7-amine
  参考文献：
  名称：

  Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses

  摘要：

  Herpesviruses are a significant source of human disease; amongst these herpes simplex virus 1 (HSV-1) and HSV-2 are very prevalent and cause recurrent infections. We recently identified a pyrazolo[1,5-a]pyridine scaffold that showed promising activity against HSV-1 and HSV-2 in Vero cell antiviral assays. Here, we describe the synthesis and anti-herpetic activity of several 3-pyrimidinyl-2-phenylpyrazolo[1,5-a]pyridines with differing 2-phenyl substitution patterns. Approaches to rapidly access a number of analogs with different 2-phenyl substitution patterns are outlined. Several of the compounds described have comparable activity to acyclovir against HSV-1 and HSV-2. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.05.043
• 作为产物：
  描述：

  2-(6-氯-2-吡啶基)-1-(4-甲氧基苯基)乙酮肟 在 三氟化硼乙醚 、 三乙胺 、 三氟乙酸酐 作用下， 以 乙二醇二甲醚 、 甲苯 为溶剂， 反应 8.0h， 生成 1-[7-chloro-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone
  参考文献：
  名称：

  Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses

  摘要：

  Herpesviruses are a significant source of human disease; amongst these herpes simplex virus 1 (HSV-1) and HSV-2 are very prevalent and cause recurrent infections. We recently identified a pyrazolo[1,5-a]pyridine scaffold that showed promising activity against HSV-1 and HSV-2 in Vero cell antiviral assays. Here, we describe the synthesis and anti-herpetic activity of several 3-pyrimidinyl-2-phenylpyrazolo[1,5-a]pyridines with differing 2-phenyl substitution patterns. Approaches to rapidly access a number of analogs with different 2-phenyl substitution patterns are outlined. Several of the compounds described have comparable activity to acyclovir against HSV-1 and HSV-2. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.05.043

文献信息

• Therapeutic compounds
  申请人：——

  公开号：US20040072853A1

  公开（公告）日：2004-04-15

  The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. 1

  本发明提供了式(I)的化合物：其中所有变量如本文所定义，包含这些化合物的药物组合物，制备这些化合物的方法以及它们作为药物代理的用途。
• Pyrazolopyridinyl pyrimidine therapeutic compounds
  申请人：SmithKline Beecham Corporation

  公开号：US07153855B2

  公开（公告）日：2006-12-26

  The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了公式(I)的化合物：包含它们的药物组合物，制备它们的方法以及它们作为药物剂的应用。
• Therapeutic Compounds
  申请人：Boyd Leslie F.

  公开号：US20060293344A1

  公开（公告）日：2006-12-28

  The present invention provides compounds of formula (I); pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了式(I)的化合物；包含相同化合物的药物组合物，制备相同化合物的方法以及它们作为药物剂量的使用。
• Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds
  申请人：Chamberlain Stanley D.

  公开号：US06919352B2

  公开（公告）日：2005-07-19

  The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了式(I)的化合物：其中所有变量均如本文所定义，含有其的制药组合物，制备该化合物的方法以及它们作为制药剂的用途。
• PYRAZOLOPYRIDINES
  申请人：GLAXO GROUP LIMITED

  公开号：EP1341788B1

  公开（公告）日：2005-08-10