β-D-galactopyranosyl-(1->6)-D-mannopyranose | 536-11-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-D-galactopyranosyl-(1->6)-D-mannopyranose
• 英文别名: 6-O-beta-D-Galactopyranosyl-D-mannopyranose；(3S,4S,5S,6R)-6-[[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxane-2,3,4,5-tetrol
• CAS: 536-11-8；645-03-4；902-54-5；3031-35-4；4604-26-6；5340-95-4；5995-99-3；5996-00-9；13299-20-2；13299-21-3；15548-40-0；16750-26-8；16967-97-8；23339-29-9；24822-33-1；33428-65-8；34674-94-7；35867-21-1；37169-69-0；37169-72-5；38533-27-6；50271-70-0；65207-30-9；82729-73-5；95463-59-5；100427-99-4；100430-37-3；100483-14-5；102572-70-3；110658-40-7；123809-47-2；140461-60-5；143615-15-0
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: DLRVVLDZNNYCBX-LXWPXHRFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  β-D-galactopyranosyl-(1->6)-D-mannopyranose 在 CMP-唾液酸合成酶 、 Pasteurella multocida multifunctional sialyltransferase Tris-HCl buffer 、 recombinant E_. coli sialic acid aldolase 、 胞苷-5’-三磷酸 、 magnesium chloride 作用下， 反应 27.0h， 生成
  参考文献：
  名称：

  Aldolase-Catalyzed Synthesis of β-d-Galp-(1→9)-d-KDN:  A Novel Acceptor for Sialyltransferases

  摘要：

  [graphics]beta-D-Galp-(1 -> 9)-D-KDN, a disaccharide component of the cell wall of Streptomyces sp. MB-8, was synthesized from beta-D-Galp-(1 -> 6)-D-Manp and pyruvate using a sialic acid aldolase. The obtained KDN-containing compound was a novel acceptor for bacterial sialyltransferases. Unusual alpha 2,3- and alpha 2,6-linked sialyltrisaccharides and a tetrasaccharide were synthesized using a one-pot two-enzyme system containing a Neisseria meningitidis CMP-sialic acid synthetase and a Pasteurella multocida sialyltransferase or a Photobacterium damsela alpha 2,6-sialyltransferase.

  DOI：

  10.1021/ol060736m
• 作为产物：
  描述：

  acetyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-2,3,4-tri-O-acetyl-α-D-mannopyranoside 在 甲醇 、 sodium methylate 作用下， 以100%的产率得到β-D-galactopyranosyl-(1->6)-D-mannopyranose
  参考文献：
  名称：

  Aldolase-Catalyzed Synthesis of β-d-Galp-(1→9)-d-KDN:  A Novel Acceptor for Sialyltransferases

  摘要：

  [graphics]beta-D-Galp-(1 -> 9)-D-KDN, a disaccharide component of the cell wall of Streptomyces sp. MB-8, was synthesized from beta-D-Galp-(1 -> 6)-D-Manp and pyruvate using a sialic acid aldolase. The obtained KDN-containing compound was a novel acceptor for bacterial sialyltransferases. Unusual alpha 2,3- and alpha 2,6-linked sialyltrisaccharides and a tetrasaccharide were synthesized using a one-pot two-enzyme system containing a Neisseria meningitidis CMP-sialic acid synthetase and a Pasteurella multocida sialyltransferase or a Photobacterium damsela alpha 2,6-sialyltransferase.

  DOI：

  10.1021/ol060736m