3,3'-二羟基联苯胺 | 2373-98-0

• 物质功能分类: 医药中间体 - 噻吩类化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,3'-二羟基联苯胺
• 中文别名: 二羟基联苯胺；3,3'-二羟基-4,4'-联苯二胺；3,3’-二羟基联苯胺；3,3"-二羟基联苯胺；3,3"-二羟基-4,4"-联苯二胺；3,3-二羟基联苯胺；p-HAB
• 英文名称: 3,3'-dihydroxybenzidine
• 英文别名: 3,3'-dihydroxy-4,4'-diaminobiphenyl；3,3’-dihydroxybenzidine；2-amino-5-(4-amino-3-hydroxyphenyl)phenol
• CAS: 2373-98-0
• 化学式: C₁₂H₁₂N₂O₂
• mdl: MFCD00039149
• 分子量: 216.239
• InChiKey: ZGDMDBHLKNQPSD-UHFFFAOYSA-N

物化性质

• 熔点：
  292 °C
• 沸点：
  356.65°C (rough estimate)
• 密度：
  1.1710 (rough estimate)
• 物理描述：
  3,3'-dihydroxybenzidine appears as colorless crystals. (NTP, 1992)
• 分解：
  When heated to decomposition, it emits toxic fumes of /nitrogen oxides/.

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.5
• 氢给体数：
  4
• 氢受体数：
  4

ADMET

代谢

某些基于联苯胺的染料中的偶氮键可以被小肠和大肠中通常存在的各种细菌和酵母还原，从而释放出联苯胺。/基于联苯胺的染料/

Various bacteria and yeast normally found in the small and large intestine can reduce the azo bond in /some/ benzidine-based dyes and release benzidine. /Benzidine-based dyes/

来源:Hazardous Substances Data Bank (HSDB)

代谢

人类以及其他哺乳动物可以将某些基于联苯胺的染料（metabolize）变回联苯胺。某些基于联苯胺的染料主要在肝脏中代谢为联苯胺，但其他器官也能在一定程度上进行这种代谢。/基于联苯胺的染料/

Humans as well as other mammals can change (metabolize) /some/ benzidine-based dyes back to benzidine. The major organ in which /some/ benzidine-based dyes are metabolized to benzidine is the liver, but other organs also can do this to a greater or lesser degree. /Benzidine-based dyes/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

高铁血红蛋白血症 - 血液中高铁血红蛋白含量增加；该化合物被归类为次要的毒性效应。

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，并在需要时辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，并在必要时进行治疗……。监测休克，并在必要时进行治疗……。预期癫痫发作，并在必要时进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于昏迷、严重肺水肿或呼吸停止的患者，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。监测心率和必要时治疗心律失常... . 使用D5W/SRP开始静脉输液："保持开放"，最低流速/. 如果出现低血容量的迹象，使用乳酸钠林格液。注意液体过载的迹象。考虑使用药物治疗肺水肿... . 对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象... . 使用地西泮（安定）治疗癫痫... . 使用丙美卡因氢氯化物协助眼部冲洗... . /毒药A和B/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

口服3,3'-二羟基联苯胺导致肝癌高发病率。

ORAL ADMIN OF 3,3'-DIHYDROXYBENZIDINE CAUSED A HIGH INCIDENCE OF HEPATOMA.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

疑似致癌物，具有实验性致癌、促瘤形成和致肿瘤数据。

Suspected carcinogen with experimental carcinogenic, neoplastigenic, & tumorigenic data.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

四个染料制造设施工人的平均环境暴露水平分别为4.3、5.2、11.7和17.4毫克/立方米总颗粒物。相应尿液中联苯胺的平均浓度分别为52、11、10和112 ppb，分别从制造过程中的前驱体中得出。/基于联苯胺的染料/

The average environmental exposure levels of four of the workers /in a dye manufacturing facility/ were 4.3, 5.2, 11.7, and 17.4 mg total particulate/cu m. The corresponding urinary concentrations of benzidine average 52, 11, 10, and 112 ppb, respectively /SRP: from the precursor during manufacturing/. /Benzidine-based dyes/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  T
• 安全说明：
  S22,S53
• 危险类别码：
  R40
• 海关编码：
  2922199090
• RTECS号：
  DV4900000
• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  室温

SDS

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Section I.Chemical Product and Company Identification
Chemical Name 3,3'-Dihydroxybenzidine
Portland OR
Synonym [1,1'-Biphenyl]-3,3'-diol, 4,4'-diamino- (CA INDEX
NAME);
4,4'-Diamino-3,3'-dihydroxybiphenyl; Benzidine-3,3'-diol
Chemical Formula C12H12N2O2
2373-98-0
CAS Number

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Section II. Composition and Information on Ingredients
Chemical Name CAS Number Percent (%) TLV/PEL Toxicology Data
3,3'-Dihydroxybenzidine 2373-98-0 Min. 98.0 This chemical is classified as a Not available.
(HPLC,T) carcinogen. There is no
acceptable exposure limit for a
carcinogen.

---

Section III. Hazards Identification
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
Acute Health Effects
eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria.
Chronic Health Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Tumorigenic effects.
Rat TDLo Oral 9950 mg/kg for 52 weeks intermittent
Toxic Effects:
Tumorigenic - Neoplastic by RTECS criteria
Skin and Appendages - Tumors
Rat TDLo Subcutaneous 5900 mg/kg for 43 weeks intermittent
Toxic Effects:
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - Tumors
Liver - Tumors
Mouse TDLo Oral 11 gm/kg for 47 weeks intermittent
Toxic Effects:
Tumorigenic - Equivocal tumorigenic agent by RTECS criteria
Lung, Thorax, or Respiration - Tumors
Blood - Tumors
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

---

Section IV. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention.
Skin Contact In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Inhalation If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
Ingestion INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.
Continued on Next Page
3,3'-Dihydroxybenzidine

---

Section V. Fire and Explosion Data
Not available.
Flammability May be combustible at high temperature. Auto-Ignition
Flammable Limits Not available.
Flash Points Not available.
Combustion Products These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2).
Fire Hazards
Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.

---

Section VI. Accidental Release Measures
Irritating material. Carcinogenic material.
Spill Cleanup
Use a shovel to put the material into a convenient waste disposal container. Consult federal, state, and/or local authorities for
Instructions
assistance on disposal.

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Section VII. Handling and Storage
IRRITANT. CARCINOGEN. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container
Handling and Storage
and store in a dry, cool place. Avoid excessive heat and light. Do not breathe dust.
Information
Always store away from incompatible compounds such as oxidizing agents.

---

Section VIII. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
Engineering Controls
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Splash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
Personal Protection
specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure Limits This chemical is classified as a carcinogen. There is no acceptable exposure limit for a carcinogen.

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Section IX. Physical and Chemical Properties
Solid. (Light yellow ~ reddish-yellow, Solubility
Physical state @ 20°C Soluble in DMF.
crystalline powder ~ powder.)
Very slightly soluble in water.
Not available.
Specific Gravity
Molecular Weight 216.24 Partition Coefficient Not available.
Boiling Point Not available. Not applicable.
Vapor Pressure
Melting Point 292°C (557.6°F) Vapor Density Not available.
Not available. Not available.
Refractive Index Volatility
Critical Temperature Not available. Odor Not available.
Not available. Not available.
Viscosity Taste

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Section X. Stability and Reactivity Data
Stability

---

This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of Instability Avoid excessive heat and light.
Incompatibilities Reactive with oxidizing agents.

---

Section XI. Toxicological Information
RTECS Number DV4900000
Eye Contact. Ingestion. Inhalation.
Routes of Exposure
Not available.
Toxicity Data
Continued on Next Page
3,3'-Dihydroxybenzidine
Chronic Toxic Effects CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Tumorigenic effects.
Rat TDLo Oral 9950 mg/kg for 52 weeks intermittent
Toxic Effects:
Tumorigenic - Neoplastic by RTECS criteria
Skin and Appendages - Tumors
Rat TDLo Subcutaneous 5900 mg/kg for 43 weeks intermittent
Toxic Effects:
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - Tumors
Liver - Tumors
Mouse TDLo Oral 11 gm/kg for 47 weeks intermittent
Toxic Effects:
Tumorigenic - Equivocal tumorigenic agent by RTECS criteria
Lung, Thorax, or Respiration - Tumors
Blood - Tumors
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Acute Toxic Effects Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

---

Section XII. Ecological Information
Not available.
Ecotoxicity
Environmental Fate Not available.

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Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

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Section XIV. Transport Information
DOT Classification Not a DOT controlled material (United States).
PIN Number Not applicable.
Proper Shipping Name Not applicable.
Packing Group (PG) Not applicable.
DOT Pictograms

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Section XV. Other Regulatory Information and Pictograms
TSCA Chemical Inventory This product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS Classification CLASS D-2B: Material causing other toxic effects (TOXIC).
(Canada)
EINECS Number (EEC) Not available.
EEC Risk Statements R36/37/38- Irritating to eyes, respiratory system and skin.
R45- May cause cancer.
3,3'-Dihydroxybenzidine
TCI laboratory chemicals are for research purposes only and are NOT intended for use as drugs, food additives, households, or pesticides. The information herein is believed to be correct, but does not claim
to be all inclusive and should be used only as a guide. Neither the above named supplier nor any of its subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information
contained herein. Final determination of suitability of any material is the sole responsibility of the user. All chemical reagents must be handled with the recognition that their chemical, physiological,
toxicological, and hazardous properties have not been fully investigated or determined. All chemical reagents should be handled only by individuals who are familiar with their potential hazards and who have
been fully trained in proper safety, laboratory, and chemical handling procedures. Although certain hazards are described herein, we can not guarantee that these are the only hazards which exist. Our MSDS
sheets are based only on data available at the time of shipping and are subject to change without notice as new information is obtained. Avoid long storage periods since the product is subject to degradation
with age and may become more dangerous or hazardous. It is the responsibility of the user to request updated MSDS sheets for products that are stored for extended periods. Disposal of unused product
must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment (e.g. protective
goggles, protective clothing, breathing equipment, facial mask, fume hood). For proper handling and disposal, always comply with federal, state, and local regulations.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途

3,3'-二羟基联苯胺用作有机和医药中间体。

反应信息

• 作为反应物：
  描述：

  3,3'-二羟基联苯胺 在 异喹啉 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 为溶剂， 反应 14.0h， 生成 3,3'-bis(cinnamate)-4,4'-diphthalimidobiphenyl
  参考文献：
  名称：

  光反应性聚酰亚胺薄膜的光反应和光诱导分子取向及其液晶取向

  摘要：

  通过常规溶液旋铸和干燥工艺成功合成了具有侧基肉桂酸酯（CI）生色团的可溶性光反应性聚酰亚胺（PSPI），该薄膜通过常规溶液旋铸和干燥过程形成了高质量的薄膜：聚（3,3'-双（肉桂酰氧基） ）-4，4′-联苯六氟异丙基二烯二酰亚胺（6F-HAB-CI）。该6F-HAB-CI PSPI在高达340°C的温度下具有热稳定性，其玻璃化转变温度（T g）为181°C，通过棱镜耦合确定为正双折射。PSPI在溶液和薄膜中的光化学反应，以及通过将其薄膜暴露于线偏振紫外线（LPUVL）诱导的PSPI分子取向，通过核磁共振，紫外可见光进行了详细研究，红外和拉曼光谱，并通过溶出度测试和光学延迟测量。证实了PSPI的CI发色团经历了光异构化和光二聚化。发现LPUVL暴露引起薄膜中聚合物主链和CI侧基的各向异性取向。而且，LPUVL辐照的薄膜相对于LPUVL的偏振沿107°角的方向均匀排列向列液晶（LC）分子，该偏

  DOI：

  10.1021/ma034445u
• 作为产物：
  描述：

  2,6-二硝基苯酚 在 ammonium hydroxide 、 硫酸 、 palladium on activated charcoal 、 platinum on activated charcoal 、 氢气 、 双氧水 、 copper(II) sulfate 、 三乙胺 、 sodium iodide 、 sodium nitrite 作用下， 以 甲醇 、 乙酸乙酯 、 1,2-二氯乙烷 、 异丙醇 、 甲苯 为溶剂， 20.0~110.0 ℃ 、800.01 kPa 条件下， 生成 3,3'-二羟基联苯胺
  参考文献：
  名称：

  一种利用芳烃硝化副产物合成苯并恶唑类化合物及应用

  摘要：

  本发明公开了一种利用芳烃硝化副产物合成苯并恶唑类化合物的方法及应用。其主要过程可表述为：将2,4‑二硝基氯化苯生产企业的硝化副产物，经分步结晶的方式，得到2,4‑二硝基氯化苯、2,6‑二硝基氯化苯(I)及少量残留物。其中2,6‑二硝基氯化苯(I)为主要起始原料，经过水解、选择性催化加氢还原、环合、卤代及碳碳偶联等过程合成苯并恶唑类化合物；再以上述过程得到的化合物为主要原料，合成一系列具有重要用途的化工中间体，如邻氨基苯酚、2‑氨基‑4‑硝基苯酚、2‑氨基‑5‑硝基苯酚及其盐酸盐等。该公开方法将工业副产转化为高附加值的芳香族氨基酚类产品，减少了2,4‑二硝基氯化苯生产企业工业危废、拓展了企业展品范围、增加了企业经济效益。

  公开号：

  CN110156712A
• 作为试剂：
  描述：

  2-phenyl[1,3,2]dioxaborolane 、 辛烯 在 3,3'-二羟基联苯胺 、 氧气 、 palladium diacetate 、 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 48.0h， 生成 (E)-1-phenyl-1-octene 、 (Z)-oct-1-enylbenzene
  参考文献：
  名称：

  Covalent Organic Framework as a Heterogeneous Ligand for the Regioselective Oxidative Heck Reaction

  摘要：

  A simple imine-based covalent organic framework (COF) as heterogeneous ligand for Pd-II-promoted Hcck reaction is reported. Good regioselectivity for a wide range of electronically unbiased olefins is obtained (linear/branched >100:1 in most cases). Related tests and density functional theory calculations are used to explore the reason underlying the high selectivity. This research opens a route for COF as an intriguing platform to control regioselectivity catalysis.

  DOI：

  10.1021/acs.orglett.0c00061

文献信息

• Effect of multiple H-bonding on the properties of polyimides containing the rigid rod groups
  作者：Xiaoye Ma、Chuanqing Kang、Wenhui Chen、Rizhe Jin、Haiquan Guo、Xuepeng Qiu、Lianxun Gao

  DOI：10.1002/pola.27808

  日期：2016.2.15

  To investigate the influence of hydrogen bonding on the properties of polyimides (PIs) containing rigid rod‐like groups, five symmetrical diamines containing benzimidazole, benzoxazole, and hydroxy group were synthesized, and then a series of PIs were prepared. Results showed that hydroxyl‐containing poly(benzoxazole imide)s possess higher glass transition temperature (Tg) and dimensional stabilities

  为了研究氢键对含有刚性棒状基团的聚酰亚胺（PI）性能的影响，合成了五个对称的含苯并咪唑，苯并恶唑和羟基的二胺，然后制备了一系列PI。结果表明，含羟基的聚（苯并恶唑酰亚胺）比相应的聚（苯并恶唑酰亚胺）具有更高的玻璃化转变温度（T g）和尺寸稳定性。此外，相应的聚苯并咪唑酰亚胺表现出最好的性能，例如最高的T g，最高的char产量和最高的尺寸稳定性。苯并咪唑的氢键作用对PIs性能的影响强于羟基。在400°C热处理后，在交联结构中形成了含羟基的聚苯并恶唑酰亚胺。©2015 Wiley Periodicals，Inc. J. Polym。科学，A部分：Polym。化学 2016，54，570-581
• [EN] PHOTOALIGNING MATERIAL<br/>[FR] MATÉRIAU DE PHOTOALIGNEMENT
  申请人：ROLIC AG

  公开号：WO2013017467A1

  公开（公告）日：2013-02-07

  The present invention relates to a copolymer for the photoalignment of liquid crystals comprising a photoreactive group as given below in formula (I), compositions thereof, and its use for optical and electro optical devices, especially liquid crystal devices (LCDs).

  本发明涉及一种共聚物，用于液晶的光调向，包括如下所示的具有光反应性基团的化合物（I）的公式，以及其组合物，以及其在光学和电光设备，特别是液晶设备（LCD）中的使用。
• [EN] POLYMERS FOR USE IN ELECTRONIC DEVICES<br/>[FR] POLYMÈRES DESTINÉS À ÊTRE UTILISÉS DANS DES DISPOSITIFS ÉLECTRONIQUES
  申请人：DUPONT ELECTRONICS INC

  公开号：WO2020018617A1

  公开（公告）日：2020-01-23

  In Formula I: Qa is CRX, SiRx, GeRx, PRX, or N; Qb is CRy, SiRy, GeRy, PRy, or N; R1, R2, and R3 are the same or different at each occurrence and are F, CN, alkyl, fluoroalkyl, unsubstituted or substituted hydrocarbon aryl, unsubstituted or substituted heteroaryl, alkoxy, fluoroalkoxy, unsubstituted or substituted aryloxy, silyl, or siloxy, where adjacent R1 groups can be joined together to form a fused aromatic ring; Rx is H, F, CN, alkyl, fluoroalkyl, unsubstituted or substituted hydrocarbon aryl, unsubstituted or substituted heteroaryl, alkoxy, fluoroalkoxy, unsubstituted or substituted aryloxy, silyl, siloxy, or R6; Ry is H, F, CN, alkyl, fluoroalkyl, unsubstituted or substituted hydrocarbon aryl, unsubstituted or substituted heteroaryl, alkoxy, fluoroalkoxy, unsubstituted or substituted aryloxy, silyl, siloxy, or R7; R6 and R7 are the same or different and are NH2 ArNH2, or OArNH2; Ar is the same or different at each occurrence and is an unsubstituted or substituted C6-18 hydrocarbon aryl; m and n are the same or different and are an integer from 0-2, such that m + n < 2; x is an integer from 0-4; y and z are the same or different and are an integer from 0 to the maximum available.

  在公式I中：Qa是CRX，SiRx，GeRx，PRX或N；Qb是CRy，SiRy，GeRy，PRy或N；R1、R2和R3在每次出现时相同或不同，并且是F，CN，烷基，氟烷基，未取代或取代的碳氢基芳基，未取代或取代的杂环芳基，烷氧基，氟烷氧基，未取代或取代的芳氧基，硅烷基或硅氧基，其中相邻的R1基团可以结合在一起形成融合的芳香环；Rx是H，F，CN，烷基，氟烷基，未取代或取代的碳氢基芳基，未取代或取代的杂环芳基，烷氧基，氟烷氧基，未取代或取代的芳氧基，硅烷基，硅氧基或R6；Ry是H，F，CN，烷基，氟烷基，未取代或取代的碳氢基芳基，未取代或取代的杂环芳基，烷氧基，氟烷氧基，未取代或取代的芳氧基，硅烷基，硅氧基或R7；R6和R7相同或不同，并且是NH2 ArNH2或OArNH2；Ar在每次出现时相同或不同，并且是未取代或取代的C6-18碳氢基芳基；m和n相同或不同，并且是0-2的整数，使得m + n < 2；x是0-4的整数；y和z相同或不同，并且是0到最大可用的整数。
• Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases
  作者：C. C. Thinnes、A. Tumber、C. Yapp、G. Scozzafava、T. Yeh、M. C. Chan、T. A. Tran、K. Hsu、H. Tarhonskaya、L. J. Walport、S. E. Wilkins、E. D. Martinez、S. Müller、C. W. Pugh、P. J. Ratcliffe、P. E. Brennan、A. Kawamura、C. J. Schofield

  DOI：10.1039/c5cc06095h

  日期：——

  A Betti reaction was used for efficient generation of 2OG oxygenase inhibitors, including for KDM4 demethylases.

  使用Betti反应高效生成2OG氧化酶抑制剂，包括KDM4去甲基酶。
• 一种苯并噁唑离子化合物及包含该化合物的 PBO纤维乳液上浆剂及其制备方法
  申请人：中国科学院化学研究所

  公开号：CN111825696B

  公开（公告）日：2021-10-29

  如下式X所示的苯并噁唑离子化合物，包含所述化合物的上浆剂及其制备方法和用途。式X所示的苯并噁唑离子化合物与PBO纤维化学结构相似，有利于提高上浆剂与PBO纤维的相容性，且其制备工艺简单，易于操作。所述上浆剂克服了现有上浆剂与PBO纤维相容性差、上浆剂需使用大量的易燃易爆有机溶剂、上浆剂中纳米增强体难以有效覆盖于纤维表面等难题。所述上浆剂以水为溶剂，绿色高效，其制备简单，环保，且所述上浆剂不仅能保持PBO纤维原有的拉伸强度，还能使得复合材料的IFSS得到显著提高。

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