6-O-alpha-D-吡喃半乳糖基-beta-D-果糖呋喃糖基 alpha-D-吡喃葡萄糖苷 | 470-57-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-O-alpha-D-吡喃半乳糖基-beta-D-果糖呋喃糖基 alpha-D-吡喃葡萄糖苷
• 中文别名: 6-O-alpha-D-吡喃半乳糖基-beta-D-果糖呋喃糖基alpha-D-吡喃葡萄糖苷
• 英文名称: α-D-glucopyranosyl-(1->2)-<α-D-galactopyranosyl-(1->6)->-β-D-fructofuranoside
• 英文别名: planteose；(O⁶-α-D-galactopyranosyl-β-D-fructofuranosyl)-α-D-glucopyranoside；(O⁶-α-D-Galactopyranosyl-β-D-fructofuranosyl)-α-D-glucopyranosid；O-α-D-Galactopyranosyl-(1->6)-O-β-D-fructofuranosyl-α-D-glucopyranosid, Planetose；(2S,3R,4S,5R,6R)-2-[[(2R,3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 470-57-5
• 化学式: C₁₈H₃₂O₁₆
• 分子量: 504.442
• InChiKey: NIBVDXPSJBYJFT-ZQSKZDJDSA-N

物化性质

• 熔点：
  124
• 溶解度：
  Soluble (water), slightly soluble (ethanol)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  269
• 氢给体数：
  11
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  6-O-alpha-D-吡喃半乳糖基-beta-D-果糖呋喃糖基 alpha-D-吡喃葡萄糖苷 在 硫酸 作用下， 生成 O⁶-α-D-Galactopyranosyl-D-fructose
  参考文献：
  名称：

  Constitution of Planteose¹

  摘要：

  DOI：

  10.1021/ja01099a058
• 作为产物：
  描述：

  D-吡喃葡萄糖 、 蔗糖 在 α-半乳糖苷酶 potassium phosphate buffer 作用下， 反应 48.0h， 生成 6-O-alpha-D-吡喃半乳糖基-beta-D-果糖呋喃糖基 alpha-D-吡喃葡萄糖苷 、 棉子糖
  参考文献：
  名称：

  通过逆水解α-和β-d-半乳糖苷酶的区域选择性合成三糖

  摘要：

  摘要在长春蔓分枝杆菌的α-d-半乳糖苷酶存在下，对含有d-半乳糖和高浓度蔗糖的溶液进行孵育，得到的棉子糖和植物糖的比例约为3：2。另一方面，d-半乳糖和蔗糖溶液的循环通过由固定的α-d-半乳糖苷酶和活性炭组成的串联色谱柱组成的反应系统，仅得到棉子糖，从活性炭柱中洗脱下来的棉子糖的含量为17.6％。屈服。类似地，使用来自大肠杆菌的固定化的β-d-半乳糖苷酶柱，通过连续法仅以10.6％的收率获得了异石蜡糖。

  DOI：

  10.1016/0008-6215(89)84029-7

文献信息

• LIPID MEMBRANE STRUCTURE FOR siRNA INTRACELLULAR DELIVERY
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US20170273905A1

  公开（公告）日：2017-09-28

  A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (R 1 and R 2 represent CH 3 —(CH 2 ) n —CH═CH—CH 2 —CH═CH—(CH 2 ) m —, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and R 3 and R 4 represent a C 1-4 alkyl group or a C 2-4 alkenyl group.

  一种脂质膜结构，其中包含一种siRNA并含有一种化合物(I)作为脂质成分（其中R1和R2代表CH3-（CH2）n-CH═CH-CH2-CH═CH-（CH2）m-，n表示3至5的整数，m表示6至10的整数，p表示2至7的整数，R3和R4代表C1-4烷基或C2-4烯基）。
• LIPID MEMBRANE STRUCTURE
  申请人：Harashima Hideyoshi

  公开号：US20130195962A1

  公开（公告）日：2013-08-01

  A lipid membrane structure for delivering a substance to a target cell having satisfactory cell permeability, selectivity for target cell, and in vivo stability, wherein lipid membrane is modified with (a) a polyalkylene glycol bound with a target cell-selective ligand; and (b) a polypeptide comprising a plurality of arginine residues.

  一种脂质膜结构，用于将物质传递到目标细胞，具有令人满意的细胞渗透性、目标细胞选择性和体内稳定性，其中脂质膜被修饰为：(a)与目标细胞选择性配体结合的聚烷基乙二醇;和(b)包含多个精氨酸残基的多肽。
• Lipid membrane structure for delivery into siRNA cell
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US11517528B2

  公开（公告）日：2022-12-06

  A lipid membrane structure includes, as lipid components, a lipid compound represented by Formula (I): (R 1 )(R 2 )C(OH)—(CH 3 ) a —(O—CO) b —X  (I) [in the formula, a represents an integer of 3 to 5; b represents an integer of 0 or 1; R 1 and R 2 each independently represents a linear hydrocarbon group that may have —CO—O—; and X represents a 5- to 7-membered non-aromatic heterocyclic group or a group represented by Formula (B) (in the formula, d represents an integer of 0 to 3, and R 3 and R 4 each independently represents a C 1-4 alkyl group or a C 2-4 alkenyl group, where, R 3 and R 4 may be bonded to each other to form a 5- to 7-membered non-aromatic heterocycle (where, one or two C 1-4 alkyl groups or C 2-4 alkenyl groups may be substituted on the ring)].

  一种脂质膜结构包括以下脂质成分：由式（I）表示的脂质化合物：(R1)(R2)C(OH)—(CH3)a—(O—CO)b—X  (I)[在该式中，a表示3至5的整数；b表示0或1的整数；R1和R2各自独立地表示一个线性碳氢基团，可能具有—CO—O—；X表示一个5至7个成员的非芳香杂环基团或由式（B）表示的基团（在该式中，d表示0至3的整数，R3和R4各自独立地表示一个C1-4烷基基团或C2-4烯基基团，其中，R3和R4可以连接在一起形成一个5至7个成员的非芳香杂环（其中，环上可能有一个或两个C1-4烷基基团或C2-4烯基基团被取代）]。
• Lipid membrane structure for intracellular delivery of siRNA
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US10182987B2

  公开（公告）日：2019-01-22

  A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (R1 and R2 represent CH3—(CH2)n—CH═CH—CH2—CH═CH—(CH2)m—, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and R3 and R4 represent a C1-4 alkyl group or a C2-4 alkenyl group.

  一种脂质膜结构，在其内部封装 siRNA，并含有式 (I) 的脂质化合物作为脂质成分（R1 和 R2 代表 CH3-(CH2)n-CH═CH-CH2-CH═CH-(CH2)m-，n 代表 3 至 5 的整数，m 代表 6 至 10 的整数，p 代表 2 至 7 的整数，R3 和 R4 代表 C1-4 烷基或 C2-4 烯基）。
• LIPID MEMBRANE STRUCTURE HAVING INTRANUCLEAR MIGRATING PROPERTY
  申请人：Harashima Hideyoshi

  公开号：US20130122054A1

  公开（公告）日：2013-05-16

  A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell.