(1R,2S,4R)-1,7,7-trimethyl-2-(prop-2-yn-1-yl)bicyclo[2.2.1]heptan-2-ol | 1075748-80-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,2S,4R)-1,7,7-trimethyl-2-(prop-2-yn-1-yl)bicyclo[2.2.1]heptan-2-ol
• 英文别名: 2-endo-Propin-(2)-yl-bornanol-(2)；(1R,2S)-(-)-1,7,7-trimethyl2-(2-prop-2-ynyl)bicyclo[2.2.1]heptan-2-ol；(1R)-1,7,7-trimethyl-2-prop-2-ynyl-norbornane-2exo-ol；(1R)-1,7,7-Trimethyl-2-prop-2-inyl-norbornan-2exo-ol；(1R,2S,4R)-1,7,7-trimethyl-2-(prop-2-ynyl)bicyclo[2.2.1]heptan-2-ol；(1R,2S,4R)-1,7,7-trimethyl-2-prop-2-ynylbicyclo[2.2.1]heptan-2-ol
• CAS: 1075748-80-9
• 化学式: C₁₃H₂₀O
• 分子量: 192.301
• InChiKey: IJTFXZNUMPWUQW-RAIGVLPGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1R,2S,4R)-1,7,7-trimethyl-2-(prop-2-yn-1-yl)bicyclo[2.2.1]heptan-2-ol 在 platinum(IV) oxide 盐酸羟胺 、 氢气 、 乙胺 、 copper dichloride 作用下， 以 甲醇 、 乙醚 为溶剂， 生成 2-endo-Hexyl-bornanol-(2)
  参考文献：
  名称：

  Capmau,M.-L. et al., Bulletin de la Societe Chimique de France, 1968, p. 3233 - 3238

  摘要：

  DOI：
• 作为产物：
  描述：

  白樟油 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 作用下， 生成 (1R,2S,4R)-1,7,7-trimethyl-2-(prop-2-yn-1-yl)bicyclo[2.2.1]heptan-2-ol
  参考文献：
  名称：

  Capmau,M.-L. et al., Bulletin de la Societe Chimique de France, 1968, p. 3233 - 3238

  摘要：

  DOI：

文献信息

• One-Pot γ-Lactonization of Homopropargyl Alcohols via Intramolecular Ketene Trapping
  作者：Daichi Yamane、Haruna Tanaka、Akihiro Hirata、Yumiko Tamura、Daichi Takahashi、Yusuke Takahashi、Tohru Nagamitsu、Masaki Ohtawa

  DOI：10.1021/acs.orglett.1c00840

  日期：2021.4.2

  γ-lactonization of homopropargyl alcohols via an alkyne deprotonation/boronation/oxidation sequence has been developed. Oxidation of the generated alkynyl boronate affords the corresponding ketene intermediate, which is trapped by the adjacent hydroxy group to furnish the γ-lactone. We have optimized the conditions as well as examined the substrate scope and synthetic applications of this efficient one-pot

  已经开发了通过炔烃去质子化/硼化/氧化顺序的一锅法丙炔醇的γ-内酯化。氧化生成的炔基硼酸酯可得到相应的乙烯酮中间体，该中间体被相邻的羟基捕获，从而提供了γ-内酯。我们优化了条件，并研究了这种有效的一锅内酯化的底物范围和合成应用。
• Inhibitors of Diacylglycerol O-acyltransferase Type 1 Enzyme
  申请人：Liu Gang

  公开号：US20080293713A1

  公开（公告）日：2008-11-27

  The present invention relates to compounds of formula (I): wherein R 1 , R 2 , and R 3 , are defined herein. Pharmaceutical compositions and methods for treating DGAT- 1 related diseases or conditions are also disclosed.

  本发明涉及式(I)的化合物，其中R1、R2和R3在此定义。还公开了治疗DGAT-1相关疾病或病状的药物组合物和方法。
• INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME
  申请人：Liu Gang

  公开号：US20120041003A1

  公开（公告）日：2012-02-16

  The present invention relates to compounds of formula (I): wherein R 1 , R 2 , and R 3 , are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

  本发明涉及式(I)的化合物：其中R1，R2和R3在此定义。还公开了治疗DGAT-1相关疾病或病状的药物组合物和方法。
• Stereoselective synthesis of spirocyclic cyclopentapyrans by the Pauson–Khand reaction on camphor tethered enynes
  作者：Serdar Sezer、Yasemin Gümrükçü、Ertan Şahin、Cihangir Tanyeli

  DOI：10.1016/j.tetasy.2008.11.020

  日期：2008.12

  An intramolecular Pauson-Khand reaction of camphor tethered enynes derived from homoallyl, homomethallyl and homopropargyl alcohols is described. Homoallyl, homomethallyl, and homopropargyl moieties are easily constructed on the camphor carbonyl group with excellent diastereoselectivity due to endo-face selectivity, and with known stereochemistry. Each enantiomerically pure enyne affords the conformationally most stable diastereomeric spirocyclic cyclopenta[c]pyran ring system. (C) 2008 Elsevier Ltd. All rights reserved.
• Golse, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1959, vol. 249, p. 1912
  作者：Golse

  DOI：——

  日期：——