AM-2 | 868368-26-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: AM-2
• 英文别名: [2-(biphenyl-4-ylmethyl)-carbamyl-3-hydroxy-6-methyl-4-pyrone]；2-(biphenyl-4-ylmethyl)-carbamyl-3-hydroxy-6-methyl-4-pyrone；N-(biphenyl-4-ylmethyl)-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide；3-hydroxy-6-methyl-4-oxo-N-[(4-phenylphenyl)methyl]pyran-2-carboxamide
• CAS: 868368-26-7
• 化学式: C₂₀H₁₇NO₄
• 分子量: 335.359
• InChiKey: ZSZOBVLJWIXXND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  AM-2 在 tetraphosphorus decasulfide 、 六甲基二硅氧烷 作用下， 以 苯 为溶剂， 以50%的产率得到AM-2S
  参考文献：
  名称：

  [EN] ZINC-BINDING GROUPS FOR METALLOPROTEIN INHIBITORS
  [FR] GROUPES DE LIAISON AU ZINC POUR INHIBITEURS DE METALLOPROTEINES

  摘要：

  公开号：

  WO2005110399A3
• 作为产物：
  描述：

  曲酸 在 palladium 10% on activated carbon 盐酸 、 sodium hydroxide 、 sodium chlorite 、 氯化亚砜 、 氨基磺酸 、 氢气 、 三氧化硫吡啶 、 三乙胺 、 N,N'-二环己基碳二亚胺 、 锌 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 氯仿 、 水 、 二甲基亚砜 、 丙酮 为溶剂， 20.0~75.0 ℃ 、241.32 kPa 条件下， 生成 AM-2
  参考文献：
  名称：

  [EN] ZINC-BINDING GROUPS FOR METALLOPROTEIN INHIBITORS
  [FR] GROUPES DE LIAISON AU ZINC POUR INHIBITEURS DE METALLOPROTEINES

  摘要：

  公开号：

  WO2005110399A3

文献信息

• Polymerizable compositions, methods of making the same, and composite articles therefrom
  申请人：Qiu Zai-Ming

  公开号：US20050250921A1

  公开（公告）日：2005-11-10

  Polymerizable fluorinated polyethers are formed by Michael-type addition of a reactive fluorinated polyether to a poly(meth)acryl compound. The polymerizable fluorinated polyethers may be used to form composite articles.

  可聚合的氟化聚醚通过将反应性氟化聚醚与聚甲基丙烯酸或聚丙烯酸化合物进行迈克尔型加成反应形成。这些可聚合的氟化聚醚可以用于制备复合材料制品。
• METALLOPROTEIN INHIBITORS
  申请人：Puerta T. David

  公开号：US20070117848A1

  公开（公告）日：2007-05-24

  The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R 1 , R 2 , R 3 , and R 4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

  本发明涉及金属蛋白酶抑制剂，包括：a. 有机取代基和至少一个锌结合基团（ZBG）共价连接在一起；或者b. 通过侧链取代的ZBG，其中ZBG的公式为（I）：其中X为O或S，每个R1、R2、R3和R4分别为氢或有机基团。这些金属蛋白酶抑制剂可用于预防或治疗与病理性金属蛋白酶活性相关的病理性疾病、状况或症状，或者通过抑制该活性缓解的病理性疾病、状况或症状。
• Methods for production of platelets from pluripotent stem cells and compositions thereof
  申请人：Ocata Therapeutics, Inc.

  公开号：US10426799B2

  公开（公告）日：2019-10-01

  Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.

  提供了利用多能干细胞（如人类胚胎干细胞（hESC）和诱导多能干细胞（iPSC））生产血小板的方法。这些方法可以在不形成胚状体或多能干细胞簇的情况下进行，也可以在不使用基质诱导细胞的情况下进行。此外，其产量和/或纯度可高于先前报道的用多能干细胞生产血小板的方法。此外，还提供了包含血小板的组合物和药物制剂，最好是由多能干细胞制备的血小板。
• Potent, Selective Pyrone-Based Inhibitors of Stromelysin-1
  作者：David T. Puerta、John Mongan、Ba L. Tran、J. Andrew McCammon、Seth M. Cohen

  DOI：10.1021/ja054558o

  日期：2005.10.1

  In an effort to develop alternatives to hydroxamate-based matrix metalloproteinase inhibitors (MPIs), we have utilized the drug discovery program LUDI enhanced with the structural coordinates of a bioinorganic model complex. This method has yielded the first pyrone-based MPIs. The inhibitors demonstrate nanomolar potency against MMP-3 and are selective for MMP-3 over MMP-2 and MMP-1. We postulate that the potency and unusual selectivity profile of these MPI is attributable to the pyrone chelating group.
• Metalloprotein Inhibitors
  申请人：Puerta David T.

  公开号：US20080161362A1

  公开（公告）日：2008-07-03

  The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R 1 , R 2 , R 3 , and R 4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.