methyl 4-methoxy-2,5-dimethylphenethylcarbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: methyl 4-methoxy-2,5-dimethylphenethylcarbamate
• 英文别名: (4-methoxy-2,5-dimethyl-phenethyl)-carbamic acid methyl ester；(4-Methoxy-2.5-dimethyl-β-phenaethyl)-carbamidsaeure-methylester；(4-Methoxy-2,5-dimethyl-phenaethyl)-carbamidsaeure-methylester；methyl N-[2-(4-methoxy-2,5-dimethylphenyl)ethyl]carbamate
• 化学式: C₁₃H₁₉NO₃
• 分子量: 237.299
• InChiKey: QRKYZXYRIBCALH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 4-methoxy-2,5-dimethylphenethylcarbamate 在 咪唑 、 lithium aluminium tetrahydride 、 palladium 10% on activated carbon 、 氢氟酸 、 氢溴酸 、 四氯化钛 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， -78.0~110.0 ℃ 、275.8 kPa 条件下， 反应 50.17h， 生成 (S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-(5,8-dimethyl-2-(2,2,2-trifluoroacetyl)-7-(((trifluoromethyl)sulfonyl)oxy)-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-hydroxyacetate
  参考文献：
  名称：

  [EN] TETRAHYDROISOQUINOLINE DERIVATIVES
  [FR] DÉRIVÉS DE TÉTRAHYDROISOQUINOLINE

  摘要：

  化合物的化学式（I）已经公开，并且揭示了使用含有这些化合物的组合物治疗病毒感染的方法。

  公开号：

  WO2017093938A1
• 作为产物：
  描述：

  2,5-二甲基-4-羟基苯甲醛 在 硼烷四氢呋喃络合物 、 ammonium acetate 、 potassium carbonate 、 溶剂黄146 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 23.5h， 生成 methyl 4-methoxy-2,5-dimethylphenethylcarbamate
  参考文献：
  名称：

  [EN] TETRAHYDROISOQUINOLINE DERIVATIVES
  [FR] DÉRIVÉS DE TÉTRAHYDROISOQUINOLINE

  摘要：

  化合物的化学式（I）已经公开，并且揭示了使用含有这些化合物的组合物治疗病毒感染的方法。

  公开号：

  WO2017093938A1

文献信息

• A patient with type I CD36 deficiency whose myocardium accumulated123I-BMIPP after 4 years
  作者：Kazuki Ito、Hiroki Sugihara、Takuji Tanabe、Kan Zen、Takatou Hikosaka、Yoshihiko Adachi、Shuji Katoh、Akihiro Azuma、Masao Nakagawa

  DOI：10.1007/bf02987845

  日期：2001.6

  A 73-year-old man with aortic regurgitation was examined by I-123-alpha -methyl-p-iodophenylpentadecanoic acid (BMIPP) myocardial single photon emission computed tomography (SPECT) in 1995. Myocardial accumulation was not evident on either the early or the delayed image obtained 15 minutes and 3 hours, respectively, after injecting I-123-BMIPP. Flow cytometric analysis of CD36 expression in monocytes and platelets identified a type I CD36 deficiency. The patient was hospitalized for severe heart failure in 1999. Upon admission, the cardiothoracic ratio on chest Xrays was 73%, and the left ventricular end-diastolic diameter on echocardiograms was enlarged to 77 mm. On the second day, we performed I-123-BMIPP myocardial SPECT. Myocardial accumulation was evident in the delayed, but not in the early image. We repeated I-123-BMIPP myocardial SPECT on the 10th day after admission. Myocardial accumulation was evident on both early and delayed images. Tc-99m-tetrofosmin myocardial SPECT was immediately performed after I-123-BMIPP myocardial SPECT to distinguish myocardial from pooling images in the left ventricle, but, because the images from both 99mTc-tetrofosmin and I-123-BMIPP myocardial SPECT were idential, we considered that the 123I-BMIPP myocardial SPECT images reflected the actual myocardial condition.The CD36 molecule transports long-chain fatty acid (LCFA) on the myocardial membrane, but I-123-BMIPP scintigraphy does not show any myocardial accumulation in patients with type I CD36 deficiency, indicating that myocardial LCFA uptake occurs through CD36 on the human myocardial membrane. Even though our patient had type I CD36 deficiency, BMIPP was uptaken by the myocardium during heart failure, suggesting a variant pathway on the human myocardial membrane for LCFA uptake.
• TETRAHYDROISOQUINOLINE DERIVATIVES
  申请人：ViiV Healthcare UK Limited

  公开号：EP3383866A1

  公开（公告）日：2018-10-10
• [EN] TETRAHYDROISOQUINOLINE DERIVATIVES<br/>[FR] DÉRIVÉS DE TÉTRAHYDROISOQUINOLINE
  申请人：VIIV HEALTHCARE UK LTD

  公开号：WO2017093938A1

  公开（公告）日：2017-06-08

  Compounds of Formula (I) are disclosed and methods of treating viral infections with compositions comprising such compounds.

  化合物的化学式（I）已经公开，并且揭示了使用含有这些化合物的组合物治疗病毒感染的方法。