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3-氨基-L-酪氨酸 | 300-34-5

中文名称
3-氨基-L-酪氨酸
中文别名
L-3-氨基酪氨酸
英文名称
3-amino-L-tyrosine
英文别名
L-3-Aminotyrosine;3-aminotyrosine;3-Amino-L-tyrosin;L-3-Amino-tyrosin;L-3-Aminotyrosin;(2S)-3-(3-amino-4-hydroxyphenyl)-2-azaniumylpropanoate
3-氨基-L-酪氨酸化学式
CAS
300-34-5
化学式
C9H12N2O3
mdl
——
分子量
196.206
InChiKey
POGSZHUEECCEAP-ZETCQYMHSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    427.9±45.0 °C(Predicted)
  • 密度:
    1.420±0.06 g/cm3(Predicted)
  • 溶解度:
    可溶于酸性水溶液(轻微)

计算性质

  • 辛醇/水分配系数(LogP):
    -3.1
  • 重原子数:
    14
  • 可旋转键数:
    3
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.22
  • 拓扑面积:
    110
  • 氢给体数:
    4
  • 氢受体数:
    5

安全信息

  • 海关编码:
    2922509090
  • 安全说明:
    S22,S36/37/39
  • 危险类别码:
    R20/21/22
  • 危险品运输编号:
    3439
  • 危险性防范说明:
    P261,P305+P351+P338
  • 危险性描述:
    H315,H319,H335
  • 储存条件:
    密封干燥保存。

SDS

SDS:8481ad9796dc6882d39a0c487a58a338
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Material Safety Data Sheet

Section 1. Identification of the substance
Product Name: 3-Amino-L-Tyrosine
Synonyms: (2S)-2-Amino-3-(3-amino-4-hydroxyphenyl)propanoic acid

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
Ingredient name: 3-Amino-L-Tyrosine
CAS number: 300-34-5

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H12N2O3
Molecular weight: 196.2

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section 11. Toxicological information
No data.

Section 12. Ecological information
No data.

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
Non-harzardous for air and ground transportation.

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

制备方法

生化研究。

用途简介 用途

生化研究。

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    参考文献:
    名称:
    酪氨酸酶自杀底物邻氨基酚和芳香族邻二胺的动力学表征。
    摘要:
    我们研究了作用于邻氨基酚和芳香族邻二胺的酪氨酸酶的自杀灭活,并将结果与​​相应邻邻二酚的结果进行了比较。催化常数遵循芳族邻二胺的顺序邻氨基酚>芳族邻二胺。
    DOI:
    10.1016/j.bbapap.2012.02.001
  • 作为产物:
    描述:
    L-酪氨酸盐酸tin硝酸 作用下, 生成 3-氨基-L-酪氨酸
    参考文献:
    名称:
    Waser; Lewandowski, Helvetica Chimica Acta, 1921, vol. 4, p. 660
    摘要:
    DOI:
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文献信息

  • C-terminal modified oxamyl dipeptides as inhibitors of the ICE-ced-3 family of cysteine proteases
    申请人:——
    公开号:US20020042376A1
    公开(公告)日:2002-04-11
    This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    这项发明涉及新型的oxamyl二肽ICE/ced-3家族抑制剂化合物。该发明还涉及含有这些化合物的药物组合物,以及在治疗患有炎症性、自身免疫和神经退行性疾病的患者中使用这些组合物,用于预防缺血性损伤,并用于保存即将进行移植手术的器官。
  • [EN] AZASULFURYLPEPTIDE-BASED CD36 MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS CD36 À BASE D'AZASULFURYLPEPTIDES ET UTILISATIONS DE CEUX-CI
    申请人:RSEM LTD PARTNERSHIP
    公开号:WO2016029324A1
    公开(公告)日:2016-03-03
    Novel azasulfuryl-containing peptidomimetics capable of inhibiting CD36 activity are disclosed. Use of these azasulfuryl-containing peptidomimetics for the treatment of CD36-related diseases, disorders or conditions, including TLR2-mediated inflammatory disease, disorder or condition, and methods of obtaining such azasulfuryl-containing peptidomimetics, are also disclosed.
    揭示了能够抑制CD36活性的新型含氮酰基的肽类模拟物。还揭示了利用这些含氮酰基的肽类模拟物治疗与CD36相关的疾病、紊乱或状况,包括TLR2介导的炎症性疾病、紊乱或状况的用途,以及获取这种含氮酰基的肽类模拟物的方法。
  • [EN] LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM<br/>[FR] PROMÉDICAMENTS DE LEVORANOL ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
    申请人:KEMPHARM INC
    公开号:WO2018191472A1
    公开(公告)日:2018-10-18
    The presently described technology provides compositions of one or more of oxoacids, polyethylene glycols, and vitamin compounds chemically conjugated to levorphanol ((-)-17-methylmorphinan-3-ol) to form novel prodrugs and compositions of levorphanol.
    目前描述的技术提供了一种或多种羟基酸、聚乙二醇维生素化合物与左旋吗啡醇((-)-17-甲基吗啡-3-醇)在化学上结合形成新型前药和左旋吗啡的组合物。
  • Amino acid derived prodrugs of propofol, compositions and uses thereof
    申请人:Gallop A. Mark
    公开号:US20050004381A1
    公开(公告)日:2005-01-06
    The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.
    本发明提供了丙泊酚前药、制备丙泊酚前药的方法、丙泊酚前药的药物组合物以及使用丙泊酚前药和药物组合物治疗或预防偏头痛疼痛、化疗后或手术后恶心和呕吐等疾病或失调的方法。
  • Methylphenidate-Prodrugs, Processes of Making and Using the Same
    申请人:KemPharm, Inc.
    公开号:US20150266911A1
    公开(公告)日:2015-09-24
    The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
    目前的技术是针对前药和组合物的,用于治疗包括甲基苯丙胺或甲基苯丙胺生物的至少与醇、胺、羧酸醇或其衍生物结合的各种疾病和/或紊乱。在某些实施例中,这些结合物还包括至少一个连接剂。该技术还涉及合成甲基苯丙胺或甲基苯丙胺生物,结合至少一个醇、胺、羧酸醇或其衍生物或其组合的方法。
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