3-(2-Formamidobenzoyl)propionsaeure | 35402-54-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-Formamidobenzoyl)propionsaeure
• 英文别名: 4-(2-Formamidophenyl)-4-oxobutanoic acid
• CAS: 35402-54-1
• 化学式: C₁₁H₁₁NO₄
• 分子量: 221.213
• InChiKey: WREZIFMYXDIZJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  3-(2-Formamidobenzoyl)propionsaeure 在 盐酸 作用下， 生成 4-(2-氨基苯基)-4-氧代丁酸
  参考文献：
  名称：

  Rivett,D.E.; Wilshire,J.F.K., Australian Journal of Chemistry, 1971, vol. 24, p. 2717 - 2722

  摘要：

  DOI：
• 作为产物：
  描述：

  3-吲哚丙酸 在 ferrous(II) sulfate heptahydrate 、 双氧水 、 维生素 C 作用下， 以 水 、 二甲基亚砜 为溶剂， 生成 3-(2-Formamidobenzoyl)propionsaeure
  参考文献：
  名称：

  Indole-3-propionic acid has chemical chaperone activity and suppresses endoplasmic reticulum stress-induced neuronal cell death

  摘要：

  Insoluble aggregated proteins are often associated with neurodegenerative diseases. Previously, we investigated chemical chaperones that prevent the aggregation of denatured proteins. Among these, 4-phenyl butyric acid (4-PBA) has well-documented chemical chaperone activity, but is required at doses that have multiple effects on cells, warranting further optimization of treatment regimens. In this study, we demonstrate chemical chaperone activities of the novel compound indole-3-propionic acid (IPA). Although it has already been reported that IPA prevents beta-amyloid aggregation, herein we show that this compound suppresses aggregation of denatured proteins. Our experiments with a cell culture model of Parkinson's disease are the first to show that IPA prevents endoplasmic reticulum (ER) stress and thereby protects against neuronal cell death. We suggest that IPA has potential for the treatment of neurodegenerative diseases and other diseases for which ER stress has been implicated. (C) 2019 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bbrc.2019.07.074

文献信息

• Scavenger compounds for improved sequencing-by-synthesis
  申请人：QIAGEN Waltham, Inc.

  公开号：US10036011B2

  公开（公告）日：2018-07-31

  The present invention discloses methods of applications of indole-3-propionic acid, L-carnitine and O-acetyl-L-carnitine in one or more different reactive steps of a sequencing-by-synthesis workflow. The reactive steps employing these compounds include, but are not limited to, cleaving, imaging, incorporating bases and washing. The use of these new compounds provides improved sequencing performance including, but not limited to, lower error rates, higher sequence outputs and/or longer read lengths.

  本发明公开了吲哚-3-丙酸、左旋肉碱和 O-乙酰-左旋肉碱在合成测序工作流程的一个或多个不同反应步骤中的应用方法。使用这些化合物的反应步骤包括但不限于裂解、成像、加入碱基和洗涤。这些新化合物的使用提高了测序性能，包括但不限于更低的错误率、更高的序列输出和/或更长的读取长度。
• Itakura, Koichi; Uchida, Koji; Kawakishi, Shunro, Bioscience, Biotechnology and Biochemistry, 1994, vol. 58, # 3, p. 488 - 493
  作者：Itakura, Koichi、Uchida, Koji、Kawakishi, Shunro

  DOI：——

  日期：——
• SAKIYAMA, FUMIO;NAKADZAVA, TAKASI
  作者：SAKIYAMA, FUMIO、NAKADZAVA, TAKASI

  DOI：——

  日期：——
• SAITO ISAO; IMUTA MITSURU; MATSUGO SEICHI; YAMAMOTO HIRAKU; MATSUURA TERU+, SYNTHESIS <SYNT-BF>, 1976, NO 4, 255-256
  作者：SAITO ISAO、 IMUTA MITSURU、 MATSUGO SEICHI、 YAMAMOTO HIRAKU、 MATSUURA TERU+

  DOI：——

  日期：——
• JPS5579366A
  申请人：——

  公开号：JPS5579366A

  公开（公告）日：1980-06-14