2-(4-溴苯基磺酰氨基)乙酸 | 13029-73-7

• 物质功能分类: 原料药 - 人工合成抗感染类药 - 磺胺类药及增效剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(4-溴苯基磺酰氨基)乙酸
• 中文别名: 2-([(4-溴苯基)磺酰基]氨基)乙酸
• 英文名称: [(4-bromophenyl)sulfonylamino]acetic acid
• 英文别名: 2-(4-bromophenylsulfonamido)acetic acid；((4-bromophenyl)sulfonyl)glycine；2-[(4-bromophenyl)sulfonylamino]acetic acid
• CAS: 13029-73-7
• 化学式: C₈H₈BrNO₄S
• mdl: MFCD01935943
• 分子量: 294.126
• InChiKey: NDAHRASKKXWZMD-UHFFFAOYSA-N

物化性质

• 熔点：
  195-198°C
• 沸点：
  464.8±55.0 °C(Predicted)
• 密度：
  1.757±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2935009090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-(4-Bromophenylsulfonamido)acetic acid
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-(4-Bromophenylsulfonamido)acetic acid
CAS number: 13029-73-7

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C8H8BrNO4S
Molecular weight: 294.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide, sulfur oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-(4-溴苯基磺酰氨基)乙酸 在 氯化亚砜 、 N,N-二甲基甲酰胺 作用下， 以 乙醚 为溶剂， 反应 6.0h， 以80%的产率得到[(4-bromophenyl)sulfonylamino]acetyl chloride
  参考文献：
  名称：

  新型含内酰胺的苯磺酰胺：设计，合成以及计算机和体外研究

  摘要：

  使用结构活性计算机模型（网络服务PASS Online，AntiBac-Pred和GUSAR急性毒性）设计和分析了一组新的含芳基磺酰基甘氨酸1a-d和2a-d的内酰胺的衍生物。对于这些衍生物，预测了其对金黄色葡萄球菌的抗菌活性以及低毒性。化合物1a-d和2a-d是通过N-三甲基甲硅烷基内酰胺与4-取代的[（苯基）磺酰基]氨基乙酰氯的反应合成的。通过IR光谱，NMR光谱和元素分析数据确认了新化合物的结构。根据体外研究结果，化合物1a–d和2a–d有效抑制金黄色葡萄球菌的生长。在位置4处带有溴原子或甲基或硝基的含内酰胺的苯磺酰胺表现出最明显的活性。

  DOI：

  10.1007/s11172-021-3112-8
• 作为产物：
  描述：

  聚甘氨酸 、 4-溴苯磺酰氯 在 sodium hydroxide 作用下， 以 乙醚 为溶剂， 反应 3.0h， 生成 2-(4-溴苯基磺酰氨基)乙酸
  参考文献：
  名称：

  杂环系统合成中的氨基酸：含有磺酰胺部分的新型生物活性三唑的合成和辐射稳定性

  摘要：

  许多新型三唑 2a–f、4、9、10、12、15；三唑并噻二唑 6、8、11、16；三唑噻二嗪 5; 合成了三唑并三嗪 14 并通过元素分析和光谱数据进行了表征。与杀真菌剂 Mycostatine 相比，其中六种化合物显示出抗真菌活性。生物活性化合物 4、8、9b 和 10 在干燥状态下的放射灭菌可能证明适用于 25 kGy 的无菌剂量。© 2002 Wiley Periodicals, Inc. 杂原子化学 13:316–323, 2002; 在线发表于 Wiley Interscience (www.interscience.wiley.com)。DOI 10.1002/hc.10037

  DOI：

  10.1002/hc.10037

文献信息

• Protease inhibitors – Part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido- glycine hydroxamate inhibitors of Clostridium histolyticum collagenase
  作者：A Scozzafava

  DOI：10.1016/s0223-5234(00)00127-6

  日期：2000.3

  Reaction of alkyl/arylsulfonyl halides with glycine afforded a series of derivatives which were first N-benzylated by treatment with benzyl chloride, and then converted to the corresponding hydroxamic acids with hydroxylamine in the presence of carbodiimide derivatives. Other derivatives were obtained by reaction of N-benzyl-glycine with aryl isocyanates, arylsulfonyl isocyanates or benzoyl isothiocyanate

  烷基/芳基磺酰基卤化物与甘氨酸反应得到一系列衍生物，其首先通过用苄基氯处理而被N-苄基化，然后在碳二亚胺衍生物存在下用羟胺转化成相应的异羟肟酸。如上所述，通过使N-苄基-甘氨酸与芳基异氰酸酯，芳基磺酰基异氰酸酯或苯甲酰基异硫氰酸酯反应，然后将它们的COOH基团转化为CONHOH部分，可获得其他衍生物。分析了这里报道的90种新化合物作为溶组织梭状芽孢杆菌胶原酶（EC 3.4.24.3）的抑制剂，这是一种锌酶，可降解天然胶原的三个螺旋区域。所制备的异羟肟酸酯衍生物的活性通常比相应的羧酸盐高100-500倍。在一系列合成异羟肟酸酯中，导致最佳抑制剂的取代模式是涉及全氟烷基磺酰基和取代的芳基磺酰基部分的那些，例如五氟苯基磺酰基，3-和4-羧基苯基磺酰基-，3-三氟甲基-苯基磺酰基或1-和2-萘基。因此，似乎与基质金属蛋白酶（MMP）异羟肟酸酯抑制剂相似，溶组织梭状芽孢杆菌胶原酶抑制剂应在P（1'）
• Inhibition of aldose reductases from rat and bovine lenses by hydantoin derivatives.
  作者：KAZUHIRO INAGAKI、ICHITOMO MIWA、TAMOTSU YASHIRO、JUN OKUDA

  DOI：10.1248/cpb.30.3244

  日期：——

  The development of potent aldose reductase inhibitors as therapeutic agents for diabetic complications is highly desirable. The inhibitory action of 54 hydantoin derivatives consisting of 25 hydantoins, 21 2-thiohydantoins and 8 2-alkylthiohydantoins was therefore tested on rat and bovine lens aldose reductases in vitro. 1-(Phenylsulfonyl)-hydantoin (18) and its derivatives, 1-[(substituted phenyl) sulfonyl] hydantoins, were found to be potent inhibitors of the enzymes. 1-[(p-Bromophenyl) sulfonyl] hydantoin (49) was the most potent among them. It inhibited purified rat and bovine lens aldose reductases by 50% at 7×10-7M and 3.7×10-7M, respectively. Inhibition of rat and bovine lens aldose reductases by this compound (49) was due to its non-ionized form, but not the ionized form, and was of a non-competitive type with respect to DL-glyceraldehyde as a substrate.

  开发强效醛糖还原酶抑制剂作为糖尿病并发症的治疗药物是非常有必要的。因此，我们在体外测试了 54 种海因衍生物对大鼠和牛晶状体醛糖还原酶的抑制作用，其中包括 25 种海因、21 种 2-硫代海因和 8 种 2-烷基硫代海因。结果发现，1-[（取代苯基）磺酰基]海因（18）及其衍生物 1-[（取代苯基）磺酰基]海因是酶的强效抑制剂。其中，1-[（对溴苯基）磺酰基]海因（49）的抑制作用最强。在 7×10-7M 和 3.7×10-7M 的浓度下，它对纯化的大鼠和牛晶状体醛糖还原酶的抑制率分别为 50%。该化合物（49）对大鼠和牛晶状体醛糖还原酶的抑制作用是由于其非离子化形式，而不是离子化形式，并且对作为底物的 DL-甘油醛具有非竞争类型的抑制作用。
• Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-α Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell Models
  作者：Elisa Nuti、Francesca Casalini、Stanislava I. Avramova、Salvatore Santamaria、Marina Fabbi、Silvano Ferrini、Luciana Marinelli、Valeria La Pietra、Vittorio Limongelli、Ettore Novellino、Giovanni Cercignani、Elisabetta Orlandini、Susanna Nencetti、Armando Rossello

  DOI：10.1021/jm901868z

  日期：2010.3.25

  useful target in anticancer therapy. Herein, we report the synthesis and biological evaluation of new ADAM-17 inhibitors containing an arylsulfonamidic scaffold. Among the new potential inhibitors, two very promising compounds 17 and 18 were discovered, with a nanomolar activity for ADAM-17 isolated enzyme. These compounds proved to be also the most potent in inhibiting soluble ALCAM release in cancer

  活化的白细胞粘附分子（ALCAM）在肿瘤生物学和进展中起着重要作用。我们以前的研究表明，ALCAM在上皮性卵巢癌（EOC）细胞表面表达，并通过ADAM-17介导的脱落以可溶形式释放。此过程与EOC细胞的运动性和侵袭性有关，ADAM-17的非特异性抑制剂会降低EOC的细胞运动性和侵袭性。因此，ADAM-17可能代表抗癌治疗的新靶标。在此，我们报告了含有芳基磺酰胺基支架的新型ADAM-17抑制剂的合成和生物学评估。在新的潜在抑制剂中，两种非常有前途的化合物17和18被发现具有ADAM-17分离酶的纳摩尔活性。这些化合物被证明也是抑制癌细胞中可溶性ALCAM释放的最有效剂，对A2774和SKOV3细胞系表现出纳摩尔活性。
• Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease
  作者：Devendra Kumar、Sukesh K. Gupta、Ankit Ganeshpurkar、Gopichand Gutti、Sairam Krishnamurthy、Gyan Modi、Sushil K. Singh

  DOI：10.1016/j.ejmech.2018.02.078

  日期：2018.4

  Novel multifunctional 3,6-Diphenyl-1,4-bis(phenylsulfonyl)piperazine-2,5-dione derivatives were designed and synthesized for the treatment of Alzheimer's disease (AD). The designed scaffold has blood brain barrier penetrating ability, acetylcholinesterase (AChE) and matrix metalloproteinase-2 (MMP-2) inhibition potential. Compounds 52 and 46 showed very significant inhibition against AChE, IC50 = 32.45 +/- 0.044, 28.65 +/- 0.029, BuChE, IC50 = 157.95 +/- 0.264, 160.58 +/- 0.082 and MMP-2, IC50 = 36.83 +/- 0.015, 19.57 +/- 0.005 (nM). In the enzyme kinetics study, lead molecule 46 showed noncompetitive inhibition of AChE with K-i = 7 nM and competitive inhibition of MMP-2 with K-i = 20 nM. Compounds 52 and 46 inhibited AChE-induced A beta aggregation at 20 mu M. The compounds also exhibited in-vitro antioxidant potential in DPPH assay. Further, compound 46 was found to be a promising neuroprotective agent in MC65 cells. Lead molecule 46 significantly enhanced working memory in scopolamine induced amnesia animal model at dose of 5 mg/kg dose. The mitochondrial membrane potential was restored in animals when treated with compounds 52 and 46. (C) 2018 Elsevier Masson SAS. All rights reserved.
• Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates
  作者：J.I. Levin、J.M. Chen、K. Cheung、D. Cole、C. Crago、E.Delos Santos、X. Du、G. Khafizova、G. MacEwan、C. Niu、E.J. Salaski、A. Zask、T. Cummons、A. Sung、J. Xu、Y. Zhang、W. Xu、S. Ayral-Kaloustian、G. Jin、R. Cowling、D. Barone、K.M. Mohler、R.A. Black、J.S. Skotnicki

  DOI：10.1016/s0960-894x(03)00514-6

  日期：2003.8

  The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors, all bearing a butynyloxy P1' group, was explored. In particular, compound 5j has excellent in vitro potency against isolated TACE enzyme and in cells, good selectivity over MMP-1 and MMP-9, and oral activity in an in vivo model of TNF-alpha production and a collagen-induced arthritis model. (C) 2003 Elsevier Ltd. All rights reserved.