d-α-tocopherol butyrate | 57448-95-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: d-α-tocopherol butyrate
• 英文别名: [(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] butanoate
• CAS: 57448-95-0
• 化学式: C₃₃H₅₆O₃
• 分子量: 500.806
• InChiKey: DSGCIQINMIEXST-WTBTXGFSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.6
• 重原子数：
  36
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  rac-α-tocopheryl crotonate 在 5% palladium on Al₂O₃ 、 氢气 作用下， 以 正庚烷 为溶剂， 39.84 ℃ 、600.01 kPa 条件下， 反应 2.0h， 以4.13 g的产率得到d-α-tocopherol butyrate
  参考文献：
  名称：

  [EN] NEW BUTYRATE COMPOUNDS
  [FR] NOUVEAUX COMPOSÉS DE BUTYRATE

  摘要：

  The present invention relates to butyrate compounds as well as to their synthesis and their use. Such compounds are very useful compounds, either as such or as intermediates in organic synthesis.

  公开号：

  WO2022162121A1

文献信息

• Using imidazolium-based ionic liquids as dual solvent-catalysts for sustainable synthesis of vitamin esters: inspiration from bio- and organo-catalysis
  作者：Yifeng Tao、Ruijuan Dong、Ioannis V. Pavlidis、Biqiang Chen、Tianwei Tan

  DOI：10.1039/c5gc02557e

  日期：——

  An efficient and sustainable approach using imidazolium-based ionic liquids as dual solvent-catalysts for synthesis of vitamin E ester was developed.

  开发了一种使用咪唑基离子液体作为双溶剂催化剂的高效和可持续方法，用于合成维生素E酯。
• COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY
  申请人：Verve Therapeutics, Inc.

  公开号：US20220152210A1

  公开（公告）日：2022-05-19

  Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9. Further provided herein are compositions and methods of treating conditions related to coronary disease.