[(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2,4,7,9-tetraoxo-1-oxa-3,6,8-triazaspiro[4.4]nonan-8-yl)oxolan-2-yl]methyl acetate | 1300562-87-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2,4,7,9-tetraoxo-1-oxa-3,6,8-triazaspiro[4.4]nonan-8-yl)oxolan-2-yl]methyl acetate
• CAS: 1300562-87-1
• 化学式: C₁₆H₁₇N₃O₁₂
• 分子量: 443.324
• InChiKey: RETPENYMVKMUJT-OEOWRQDASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  193
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  鸟苷 在 4-二甲氨基吡啶 、 sodium hexachloroiridate 、 palladium on carbon 、 氢气 、 溴 、 sodium 、 溶剂黄146 、 三乙胺 、 sodium nitrite 作用下， 以 水 、 二甲基亚砜 、 乙腈 为溶剂， 反应 2.5h， 生成 [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2,4,7,9-tetraoxo-1-oxa-3,6,8-triazaspiro[4.4]nonan-8-yl)oxolan-2-yl]methyl acetate
  参考文献：
  名称：

  Oxidation of 9-β-d-ribofuranosyl uric acid by one-electron oxidants versus singlet oxygen and its implications for the oxidation of 8-oxo-7,8-dihydroguanosine

  摘要：

  Uric acid, a cellular antioxidant, undergoes oxidation in the presence of one-electron oxidants as well as singlet oxygen. In the present work, the oxidation pathways and products formed from oxidation of the uric acid nucleoside are compared to the more commonly studied uric acid free base. A wider distribution of products, including allantoin, urea, caffolide, and 5-carboxamido-5-hydroxyhydantoin nucleosides, are formed when the N9 position of uric acid is glycosylated. The oxidation pathways share some features in common with the oxidation of 8-oxo-7,8-dihydroguanosine, but the additional spectrum of products implies that the combination of oxidative and deaminative damage to guanosine may lead to a more complex set of DNA lesions than originally described. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.123