4-羟基-6-甲基喹啉-3-羧酸乙酯 | 85418-82-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-羟基-6-甲基喹啉-3-羧酸乙酯
• 英文名称: ethyl 6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
• 英文别名: ethyl 6-methyl-4-oxo-1H-quinoline-3-carboxylate
• CAS: 85418-82-2
• 化学式: C₁₃H₁₃NO₃
• mdl: MFCD01847814
• 分子量: 231.251
• InChiKey: WRHXUGRUTJJRQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933499090
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  4-羟基-6-甲基喹啉-3-羧酸乙酯 在 三甲基氯硅烷 、 三氟甲磺酸三甲基硅酯 作用下， 以 乙腈 为溶剂， 反应 7.0h， 生成 ethyl 1-[(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-(benzoyloxymethyl)oxolan-2-yl]-6-methyl-4-oxoquinoline-3-carboxylate
  参考文献：
  名称：

  Molecular design, synthesis and biological evaluation of 1,4-dihydro-4-oxoquinoline ribonucleosides as TcGAPDH inhibitors with trypanocidal activity

  摘要：

  The 1,4-dihydro-4-oxoquinoline ribonucleoside, Neq135, is the first low micromolar trypanosomatidae inhibitor to show good ligand efficiency (0.28 kcal mol(-1) atom(-1)) and good ligand lipophilicity efficiency (0.37 kcal mol(-1) atom(-1)) when acting against Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase (TcGAPDH). This and other six ribonucleosides were synthesized using our in-house technology, and assayed against the GAPDH NAD(+) site using isothermal titration calorimetry (ITC). Compound Neq135 had acceptable in vitro cytotoxicity, inhibited TcGAPDH with a K-i(app) value of 16 mu M and killed the trypomastigote form of Trypanosoma cruzi Tulahuen strain with a concentration similar to that displayed by the control drug benznidazole. Neq135 is tenfold lower kinetic affinity against hGAPDH and does not kill Balb-c fibroblast nor spleen mouse cells. These results emphasize the possibility of integrating ligand- and target-based designs to uncover potent and selective TcGAPDH inhibitors that expands the opportunity for further medicinal chemistry endeavor towards NAD(+) TcGAPDH site. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.06.029
• 作为产物：
  描述：

  在 Dowtherm A 作用下， 反应 0.5h， 生成 4-羟基-6-甲基喹啉-3-羧酸乙酯
  参考文献：
  名称：

  Molecular design, synthesis and biological evaluation of 1,4-dihydro-4-oxoquinoline ribonucleosides as TcGAPDH inhibitors with trypanocidal activity

  摘要：

  The 1,4-dihydro-4-oxoquinoline ribonucleoside, Neq135, is the first low micromolar trypanosomatidae inhibitor to show good ligand efficiency (0.28 kcal mol(-1) atom(-1)) and good ligand lipophilicity efficiency (0.37 kcal mol(-1) atom(-1)) when acting against Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase (TcGAPDH). This and other six ribonucleosides were synthesized using our in-house technology, and assayed against the GAPDH NAD(+) site using isothermal titration calorimetry (ITC). Compound Neq135 had acceptable in vitro cytotoxicity, inhibited TcGAPDH with a K-i(app) value of 16 mu M and killed the trypomastigote form of Trypanosoma cruzi Tulahuen strain with a concentration similar to that displayed by the control drug benznidazole. Neq135 is tenfold lower kinetic affinity against hGAPDH and does not kill Balb-c fibroblast nor spleen mouse cells. These results emphasize the possibility of integrating ligand- and target-based designs to uncover potent and selective TcGAPDH inhibitors that expands the opportunity for further medicinal chemistry endeavor towards NAD(+) TcGAPDH site. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.06.029

文献信息

• Novel hybrids of metronidazole and quinolones: Synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin
  作者：Sheng-Feng Cui、Li-Ping Peng、Hui-Zhen Zhang、Syed Rasheed、Kannekanti Vijaya Kumar、Cheng-He Zhou

  DOI：10.1016/j.ejmech.2014.08.063

  日期：2014.10

  A novel series of hybrids of metronidazole and quinolones as antimicrobial agents were designed and synthesized. Most prepared compounds exhibited good or even stronger antimicrobial activities in comparison with reference drugs. Furthermore, these highly active metronidazole–quinolone hybrids showed appropriate ranges of pKa, log P and aqueous solubility to pharmacokinetic behaviors and no obvious

  设计并合成了一系列新型的甲硝唑和喹诺酮类抗微生物剂。与参考药物相比，大多数制备的化合物表现出良好或什至更强的抗菌活性。此外，这些高活性甲硝唑-喹诺酮杂种对药代动力学表现出适当的pKa，log P和水溶解度范围，对A549和人肝细胞LO2细胞无明显毒性。它们与金属离子对HSA的竞争性相互作用表明，Mg 2+离子参与化合物7d -HSA缔合可能导致游离化合物7d的浓度增加。化合物7d的分子建模和实验研究 DNA提示可能的抗菌机制可能与生物活性分子和topo IV-DNA复合物之间的多个结合位点有关。
• Quinoline derivatives having anti-tumor activity
  申请人：Imperial Chemical Industries PLC

  公开号：US05112837A1

  公开（公告）日：1992-05-12

  The invention relates to a quinoline of the formula: ##STR1## wherein each of R.sup.1 and R.sup.2, which may be the same or different, is hydrogen, halogeno, hydroxy, cyano, carbamoyl, nitro or amino, alkyl, alkoxy, alkylthio, alkylamino, dialkylamino or alkanoylamino each of up to 4 carbon atoms, or substituted alkyl or alkoxy each of up to 3 carbon atoms, provided that both R.sup.1 and R.sup.2 are not hydrogen; the quinoline ring may bear further substituents; R.sup.3 is hydrogen or alkyl of up to 4 carbon atoms; R.sup.4 is hydrogen, alkyl, alkenyl or alkynyl each of up to 4 carbon atoms or substituted alkyl of up to 3 carbon atoms; Ar is phenylene, naphthylene or heterocyclene which is unsubstituted or which bears one or more substituents; R.sup.5 is such that R.sup.5 --NH.sub.2 is an amino acid; or a pharmaceutically-acceptable salt or ester thereof. The compounds possess anti-tumor activity.

  本发明涉及一种喹啉，其公式为：##STR1## 其中，R.sup.1和R.sup.2可以是相同的或不同的，为氢、卤素、羟基、氰基、碳酰胺基、硝基或氨基，为碳原子数不超过4的烷基、烷氧基、烷硫基、烷氨基、二烷氨基或烷酮氨基，或为碳原子数不超过3的取代烷基或取代烷氧基，但R.sup.1和R.sup.2均不为氢；喹啉环可带有进一步的取代基；R.sup.3为氢或碳原子数不超过4的烷基；R.sup.4为氢、碳原子数不超过4的烷基、烯基或炔基，或为碳原子数不超过3的取代烷基；Ar为二价苯基、二价萘基或杂环基，其中未取代或带有1个或多个取代基；R.sup.5满足R.sup.5 --NH.sub.2是一种氨基酸；或其药用可接受的盐或酯。这些化合物具有抗肿瘤活性。
• Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca2+-activated K+ channels
  作者：Donglai Yang、Lejla Arifhodzic、C. Robin Ganellin、Donald H. Jenkinson

  DOI：10.1016/j.ejmech.2013.02.029

  日期：2013.5

  Previously, quinolinium-based tetraazacyclophanes, such as UCL 1684 and UCL 1848, have been shown to be extraordinarily sensitive to changes in chemical structure (especially to the size of the cyclophane system) with respect to activity as potent non-peptidic blockers of the small conductance Ca2+-activated K+ ion channels (SKCa). The present work has sought to optimize the structure of the linking

  以前，已证明基于喹啉鎓的四氮杂环烷酮（例如UCL 1684和UCL 1848）作为有效的小肽非肽类阻滞剂，对化学结构的变化（尤其是对环庚烷体系的大小）非常敏感。电导Ca 2+激活的K +离子通道（SK Ca）。当前的工作试图优化UCL 1848中连接链的结构。我们报道了29个UCL 1848类似物的合成和SK Ca通道阻滞活性，其中UCL 1848的中心CH 2被其他基团X或取代。 Y = O，S，CF 2，C O，CHOH，C C，CHCH，CHMe，以探索键长或柔韧性的细微变化是否可以进一步提高效力。通过合成和测试带有取代基（NO 2，NH 2，CF 3，F，Cl，CH 3，OCH 3，OCF 3， OH）在氨基喹啉鎓环的5、6或7个位置上。与我们之前的工作一样，测定了每种化合物对大鼠交感神经元后超极化（AHP）的抑制作用，这种作用是由SK Ca通道的SK3亚型介导的。一种新化合物（39，R
• Conjugate Addition Routes to 2‐Alkyl‐2,3‐dihydroquinolin‐4(1 <i>H</i> )‐ones and 2‐Alkyl‐4‐hydroxy‐1,2‐dihydroquinoline‐3‐carboxylates
  作者：Alex Kingsbury、Steve Brough、Antonio Pedrina McCarthy、William Lewis、Simon Woodward

  DOI：10.1002/ejic.201901036

  日期：2020.3.27

  quinolin‐4(1H)‐ones to provide 2‐alkyl‐2,3‐dihydroquinolin‐4(1H)‐ones (14 examples, 54–99 % yield). Asymmetric versions require AlEt3 to Boc‐protected ethyl 6‐substituted 4(1H)‐quinolone‐3‐carboxylates (6‐R group = all halogens, n/i/t‐alkyls, CF3) and provide 61–91 % yield, 30–86 % ee; any halogen, Me, or CF3 provide the highest stereoselectivities (76–86 % ee). Additions of AlMe3 or Al(nC8H17)3 provide ≈ 45 and

  在CuBr · SMe2 / PPh3催化下（5/10 mol％）RMgCl（R = Me，Et，n Pr，CH = CH 2，n Bu，i Bu，n C 5 H 11，c C 6 H 11，Bn ，CH 2 Bn，n C 11 H 23）容易地（–78°C）对Cbz或Boc保护的喹啉-4（1 H）-酮进行1,4加成，从而提供2-烷基-2-3,2-二氢喹啉- 4（1 H）-1 （14例，产率54–99％）。非对称版本需要AlEt 3到Boc保护的乙基6取代的4（1 H）-喹诺酮-3-羧酸盐（6-R基团=所有卤素，n / i / t-烷基，CF 3），收率61-91％，ee 30-86％; 任何卤素，Me或CF 3均可提供最高的立体选择性（76–86％ee）。AlMe 3或Al（n C 8 H 17）3的添加在母体中的添加提供≈45和≈75％ee（6-R = H）。配体（S）‐（BINOL）P–N（CHPh
• Construction of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as a potential antibacterial agents
  作者：Farag A. El-Essawy、Nader M. Boshta、Mshari A. Alotaibi、Mohamed S. Elsayed、Reda Tarabees、Ebtsam A. Saleh

  DOI：10.1007/s11164-016-2586-8

  日期：2016.12

  A novel series of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as antimicrobial agents were designed and synthesized. Their structures have been confirmed using spectroscopic analyses (IR, NMR, and EI-MS). Most of the newly prepared compounds were screened for their antimicrobial activities against two Gram-positive bacterial strains and six Gram-negative bacterial strains. Many of the synthesized compounds displayed a high antimicrobial activity in comparison with reference drugs, for example compounds 4–6, 15, 17, and 18.

  设计并合成了一系列新型的1,3-二取代的4-氧代-1,4-二氢喹啉类抗菌剂。通过光谱分析（IR、NMR和EI-MS）确认了它们的结构。对大多数新制备的化合物进行了抗菌活性筛选，针对两种革兰氏阳性菌株和六种革兰氏阴性菌株。与参考药物相比，许多合成的化合物显示出高度的抗菌活性，例如化合物4-6、15、17和18。