仙客来皂甙元 A | 5172-34-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 仙客来皂甙元 A
• 中文别名: 仙客来皂甙元A
• 英文名称: cyclamiretin A
• 英文别名: cyclamiritin A；(1S,2R,4S,5R,8R,10S,13R,14R,17S,18R,20S)-2,10-dihydroxy-4,5,9,9,13,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracosane-20-carbaldehyde
• CAS: 5172-34-9
• 化学式: C₃₀H₄₈O₄
• 分子量: 472.709
• InChiKey: UBWMMEPLQFWYCH-GFRLSDCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  34
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  仙客来皂甙元 A 生成 (1R,2R,4S,5R,8S,10R,13S,14R,18S,20S,21R)-21-ethoxy-4,5,9,9,13,20-hexamethyl-22-oxahexacyclo[18.3.2.01,18.04,17.05,14.08,13]pentacos-16-ene-2,10-diol
  参考文献：
  名称：

  REZNICEK, GOTTFRIED;JURENITSCH, JOHANN;ROBIEN, WOLFGANG;KUBELKA, WOLFGANG, PHYTOCHEMISTRY, 28,(1989) N 3, C. 825-828

  摘要：

  DOI：
• 作为产物：
  描述：

  3β,16α-dihydroxy-13β,28-epoxyolean-30-al 3-O-[(O-β-D-glucopyranosyl-(1→2)-O-[O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranoside)] 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 生成 D-葡萄糖 、 L-(+)-arabinose 、 (20S)-3beta,16alpha,28-三羟基齐墩果-12-烯-29-醛 、 仙客来皂甙元 A
  参考文献：
  名称：

  报春花皂苷

  摘要：

  摘要 从报春花全株中分离得到一种新的三萜皂苷，报春木苷，其特征为 3- O [β- d -吡喃木糖基-(1 → 2)-β- d -吡喃葡萄糖基-(1 → 4)-α- l -arabinopyranosyloxy]-16α-hydroxy-13β,28-epoxy-olean-30-al。

  DOI：

  10.1016/0031-9422(88)80644-7

文献信息

• Saponins in Cyclamen species: Configuration of cyclamiretin C and structure of isocyclamin
  作者：Gottfried Reznicek、Johann Jurenitsch、Wolfgang Robien、Wolfgang Kubelka

  DOI：10.1016/0031-9422(89)80123-2

  日期：1989.1

  Abstract Five sapogenins and three saponins were identified in bulbs of 14 cytologically defined Cyclamen species and their structures were determined by means of mass, 1H and 13C NMR spectroscopy. In addition to the known products of hydrolysis, primulagenin A was found, and cyclamiretin C was shown to be identical with cyclamigenin C. The new saponin isocyclamin was identified as 3β-O-β- d -glu

  摘要 在细胞学上确定的 14 种仙客来球茎中鉴定出 5 种皂苷元和 3 种皂苷，并通过质谱、1H 和 13C NMR 光谱法确定了它们的结构。除了已知的水解产物外，还发现了报春花苷 A，并且证明环米苷元 C 与环孢霉素 C 相同。新的皂苷异环胺被鉴定为 3β-O-β-d-吡喃葡萄糖基-(1-6)- [O-β-d-吡喃木糖基-(1-2)]-O-β-d-吡喃葡萄糖基-(1-4)-[O-β-d-吡喃葡萄糖基-(1-2)]-α-l-阿拉伯吡喃糖基}-16α-羟基-13β, 28-epoxy-olean-30-al。
• Triterpene compositions and methods for use thereof
  申请人：Research Development Foundation

  公开号：US20030039705A1

  公开（公告）日：2003-02-27

  The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells. The present application is a continuation-in-part of co-pending U.S. Patent Application Ser. No. 60/099,066, filed Sep. 3, 1998, and a continuation-in-part of U.S. patent application Ser. No. 60/085,997, filed May 19, 1998. The entire text of each of the above-referenced disclosures is specifically incorporated by reference herein without disclaimer.

  本发明提供了从维多利亚金合欢(Acacia victoriae)物种中分离出来的新型皂苷混合物和化合物，以及它们的使用方法。这些化合物可能包含三萜基团，如金合欢酸或齐墩果酸，附着有寡糖和单萜基团。这些混合物和化合物具有与细胞凋亡和细胞毒性调节相关的特性，并对多种肿瘤细胞表现出强效的抗肿瘤作用。本申请是待决美国专利申请号60/099,066的续篇，该专利申请于1998年9月3日提交，并且是待决美国专利申请号60/085,997的续篇，该专利申请于1998年5月19日提交。上述所有引用文件的全部内容都被明确地并入本文，不做免责声明。
• Anti-Cancer Activity of Androsace Umbellata Merr. Extract and Contained Triterpene Saponin
  申请人：Zee Ok Pyo

  公开号：US20080280839A1

  公开（公告）日：2008-11-13

  The present invention relates to an Androsace umbellata Merr. extract having anticancer activity and a triterpene saponin compound isolated therefrom, more particularly to an Androsace umbellata (Lour.) Merr. extract, triterpene saponin compounds isolated therefrom, saxifragifolin B and saxifragifolin D, which inhibit the growth of cancer cells and induce apoptosis of cancer cells, and thus are useful for preparing a composition for preventing and treating cancers and a method of isolating a triterpene saponin compound from an Androsace umbellata Merr. extract.

  本发明涉及一种具有抗癌活性的Androsace umbellata Merr.提取物及其分离出的三萜皂苷化合物，更具体地涉及一种Androsace umbellata（Lour.）Merr.提取物，其中分离出的三萜皂苷化合物为saxifragifolin B和saxifragifolin D，它们能够抑制癌细胞的生长并诱导癌细胞凋亡，因此可用于制备预防和治疗癌症的组合物以及从Androsace umbellata Merr.提取物中分离三萜皂苷化合物的方法。
• Polynucleotide binding complexes comprising sterols and saponin
  申请人：Nordic Vaccine Technology A/S

  公开号：EP2011517A1

  公开（公告）日：2009-01-07

  The present invention pertains to complexes comprising sterols and saponins. The complexes are capable of binding a genetic determinant including a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contacting group and/or a targeting ligand, and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in even further embodiments be encapsulated by an encapsulation agent including a biodegradable microsphere. The present invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practised on the human or animal body.

  本发明涉及由甾醇和皂甙组成的复合物。这些复合物能够结合包括多核苷酸在内的遗传决定因子。复合物可进一步包含亲脂分子，可选择包含接触基团和/或靶向配体的亲脂分子和/或糖分子。复合物可进一步包括免疫原决定簇和/或抗原决定簇和/或药物和/或诊断化合物。在更进一步的实施方案中，复合物可被包括生物可降解微球在内的封装剂封装。本发明还涉及通过治疗和/或手术对个体进行治疗的药物组合物和方法、美容治疗方法以及对人体或动物体进行诊断的方法。
• TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF
  申请人：RESEARCH DEVELOPMENT FOUNDATION(a Nevada corporation)

  公开号：EP1079824A1

  公开（公告）日：2001-03-07